Protein Alignment Su(dx) and TOM1

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_010745.3
• Gene: TOM1 / 852068
• SGDID: S000002865
• Length: 3268
• Species: Saccharomyces cerevisiae
• Alignment Length: 568
• Identity: 180/568 - (31%)
• Similarity: 284/568 - (50%)
• Gaps: 69/568 - (12%)

  Fly   421 TTWQRPNSERLMHF---QHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDG 482
            ||....|||.|..|   ...|.:...:::..:..|.:.:::::......|...|..:. ||:
Yeast  2725 TTGMEINSELLQKFTLPSSDQAKLLKILTTVDFLYTHKRKEEERNVKDLQSLYDKMNG-GPV--- 2785

  Fly   483 WE---------KKIQSDN------------------RVYFVNHKNRTTQWEDPRTQGQEVSLINE 520
            |.         :|.|:.|                  |.....::|...::||.:.
Yeast  2786 WSSLSECLSQFEKSQAINTSATILLPLIESLMVVCRRSDLSQNRNTAVKYEDAKL---------- 2840

  Fly   521 GPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGV----PRAYERSFRWKLSQF 581
                  .:...|.....||...:..:..........||...|.:.:    |:..:      ....
Yeast  2841 ------LDFSKTRVENLFFPFTDAHKKLLNQMIRSNPKLMSGPFALLVKNPKVLD------FDNK 2893

  Fly   582 RY-----LCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGGVSR 640
            ||     |...|.....:.|||.|:.:|.|||..:......|::. :|.|.|:||.|:|.|||:|
Yeast  2894 RYFFNAKLKSDNQERPKLPITVRREQVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTR 2958

  Fly   641 EWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGF 705
            ||:.:||.::.||.|.||.....:..:...|..|.:||:||.:|||||..|..|:....|:...|
Yeast  2959 EWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHF 3023

  Fly   706 TMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENG 770
            :...||.:|.:.:::||:|::||::|.||:|:.:|:|.:. :|..|||:.:..|:.....|.|.|
Yeast  3024 SREVYKNILGRPVSLKDMESLDPDYYKSLVWILENDITDI-IEETFSVETDDYGEHKVINLIEGG 3087

  Fly   771 EKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVD 835
            :...|||.||::|:..:.|:::...:::|...||.||..::..:.:..|||:||||::.|:.|:|
Yeast  3088 KDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDID 3152

  Fly   836 VEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRF 900
            |:||:.||.|.:|....|:|.:||:.||..|.|:||:||||||||.:||:.||.||.|.||..:|
Yeast  3153 VDDWKNNTTYVNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKF 3217

  Fly   901 CIEK-VGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEE-TEGF 946
            .|.: .|....||.||||||:|:||||:||:.|...|..||.| .|||
Yeast  3218 SIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGF 3265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		HUL4	<395..946	CDD:227354	178/566 (31%)
TOM1	NP_010745.3	DUF908	92..387	CDD:428721
		DUF913	448..>683	CDD:461803
		MSCRAMM_ClfA	<1865..2104	CDD:468110
		UBM	2327..2359	CDD:464159
		UBM	2367..2399	CDD:464159
		HUL4	2385..3268	CDD:227354	180/568 (32%)