DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_036017204.1	Gene:	Nedd4l / 83814	MGIID:	1933754	Length:	1261	Species:	Mus musculus

Alignment Length:	1056	Identity:	336/1056 - (31%)
Similarity:	454/1056 - (42%)	Gaps:	327/1056 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 TKSGELVAILNGLKLDMS-KLQIQPVAG-----QQNGNPPVQAVNPSVVSDAAAGRS-------- 213
            ||...||.... ::|:.| ....||.||     :..|.|........||.:.....|
Mouse   257 TKGDRLVRYPR-IRLERSTSYPTQPRAGRVSPTEDRGTPEASPRASRVVPEIRRTNSERTPQSPG 320

  Fly   214 CMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRR--STQAPPVWEQQQQQSQNQQQPLRMV 276
            ||        .::|...             |.|..|.|  .|:.|      ::..|||::..:..
Mouse   321 CM--------FKIRQDQ-------------NAGQQHFRILVTRGP------EEAPQNQEETHKSP 358

  Fly   277 NGSGAAVPQ--------TAPYPQQPPA-PALARPLT-------------QVYGALPENTQPAAVY 319
            ...||..|.        ..|....|.. |.:.||.|             :|.|.|    :....|
Mouse   359 GHPGAGAPTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFL----RLKMAY 419

  Fly   320 LPAGGGAAVGPPGVAGPPIEQPGV-------GLPVSQSTDPQLQTQ-PADDEPLPAGWEIRLDQY 376
            :|..||..           |:...       |..|..|.|...|.| .....|||.|||.::|..
Mouse   420 MPKNGGQD-----------EENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNL 473

  Fly   377 GRRYYVDHNTRSTYWEKP----------------------------------------------- 394
            ||.|||:||.|||.|.:|
Mouse   474 GRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGP 538

  Fly   395 ----------------------------------------------------------------- 394

Mouse   539 EPWETISEEMNMAGDSLSLALPPPPASPVSRTSPQELSEEVSRRLQITPDSNGEQFSSLIQREPS 603

  Fly   395 ------------------------------------------------TP-LPPGWEIRKDGRGR 410
                                                            || ||.|||.|||.:||
Mouse   604 SRLRSCSVTDTVAEQAHLPPPSTPTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGR 668

  Fly   411 VYYVDHNTRKTTWQRP---------------NSERLMHFQ----------------HWQGQRAHV 444
            .|||:||.|.|||.||               ::..|:..|                ..:|.:...
Mouse   669 TYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSP 733

  Fly   445 VSQGNQRYLYSQQQQQPTAVTA-----QVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQ 504
            :.:..:..|.:.|..||:...:     :|||..      ||.|||.:|..:.|.:|::|..:||.
Mouse   734 IRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSF------LPPGWEMRIAPNGRPFFIDHNTKTTT 792

  Fly   505 WEDPRTQ-----GQEVSL-INE-GPLPPGWEIRYTAAGERFFVDH---------NTRR------- 546
            |||||.:     ..:.|| .|: ||||||||.|....|..|::||         :||.
Mouse   793 WEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPLYDS 857

  Fly   547 --TTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNA-LPSHIKITVTRQTLFEDSY 608
              |.:||||...|    .:.|....|.|.|:.|...||...:..| :|:..::.:.|..:||:||
Mouse   858 KITQWEDPRLQNP----AITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESY 918

  Fly   609 HQIMRLPAYE-LRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINP 672
            .:||.:...: |:.||:|.|..|:|||||||:||||||||.|:.||.|.||||:..:||:|||||
Mouse   919 RRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINP 983

  Fly   673 AS-YVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIW 736
            .| ..|.|||.||.||||...:|::||:.:...|..||||.||.|::|:.|:|::|.|:||||.|
Mouse   984 NSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKW 1048

  Fly   737 VKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTK 801
            :.:|  |...|:|.|.:|.|..||....:||.||.:..||.|||.|||.|:.:||....:::|..
Mouse  1049 ILEN--DPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMN 1111

  Fly   802 TFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRET 865
            .|||||.|::|::.:|.|||.||||::||:.||||.||::::||:: |..|...:.|||:.|...
Mouse  1112 AFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLM 1176

  Fly   866 DNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYD 930
            |.|||.|||||||||.|||:.|||||.||||||.|.||:.|....|||:||||||||||||::::
Mouse  1177 DAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFE 1241

  Fly   931 QLVEKLTFAIEETEGF 946
            .|.|||..|:|..:||
Mouse  1242 DLREKLLMAVENAQGF 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	4/9 (44%)
		WW	364..396	CDD:197736	19/191 (10%)
		WW	397..426	CDD:278809	19/28 (68%)
		WW	478..509	CDD:197736	14/30 (47%)
		WW	522..554	CDD:197736	18/49 (37%)
		HECTc	594..946	CDD:238033	183/354 (52%)
		HECTc	620..946	CDD:214523	175/327 (54%)
Nedd4l	XP_036017204.1	PHA03378	<107..318	CDD:223065	15/61 (25%)
		C2	<367..420	CDD:417471	9/56 (16%)
		WW	465..491	CDD:395320	15/25 (60%)
		WW	655..684	CDD:395320	19/28 (68%)
		WW	768..798	CDD:238122	14/29 (48%)
		WW	817..867	CDD:197736	18/49 (37%)
		HECTc	928..1257	CDD:214523	176/330 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740