DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and ITCH

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001244066.1	Gene:	ITCH / 83737	HGNCID:	13890	Length:	903	Species:	Homo sapiens

Alignment Length:	955	Identity:	479/955 - (50%)
Similarity:	614/955 - (64%)	Gaps:	94/955 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSSGAGASGSANQGYHQLSVTIEEASLRNN--GFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWN 96
            |.|..|:.||... ..||.:|:..|.|:.|  .:..|:||||:.:|.:|| ||:...|:..|||.
Human     4 SGSQLGSMGSLTM-KSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSK-KTEKCNNTNSPKWK 66

  Fly    97 EEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNR 161
            :..||::||.|.|||:|..|.:.:.|.:||...:::...|:..|.:.|.:.:|:.|    ..|..
Human    67 QPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQL----GGDKE 127

  Fly   162 QTKS-GELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIY-------- 217
            .|:: |:|...|:||:|:...:........:||   |....|.:..::|....|.:.
Human   128 PTETIGDLSICLDGLQLESEVVTNGETTCSENG---VSLCLPRLECNSAISAHCNLCLPGLSDSP 189

  Fly   218 ----------------GGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQS 266
                            .|.|::...|.|:..|:     .|...|.|::||             .|
Human   190 ISASRVAGFTGASQNDDGSRSKDETRVSTNGSD-----DPEDAGAGENRR-------------VS 236

  Fly   267 QNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPP 331
            .|....|    .:|...|...|.|.:||.|...||.:       .|..|:|.....|......||
Human   237 GNNSPSL----SNGGFKPSRPPRPSRPPPPTPRRPAS-------VNGSPSATSESDGSSTGSLPP 290

  Fly   332 ---------GVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTR 387
                     |.....|    :.|.:|..:.|: ...|....|||.|||.|:||:||.|||||..:
Human   291 TNTNTNTSEGATSGLI----IPLTISGGSGPR-PLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEK 350

  Fly   388 STYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHV---VSQGN 449
            .|.|::|.|||||||.|.|..||:|||||.||.||||||..|.:.:::.||.||:.:   :.|.|
Human   351 RTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFN 415

  Fly   450 QRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQE 514
            ||::|..|....|:.:.:.     |.|||||.||||:..|:.|||||||..|.|||||||:|||
Human   416 QRFIYGNQDLFATSQSKEF-----DPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ- 474

  Fly   515 VSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLS 579
               :||.|||.|||:|:|..|..:|||||.|.||:.|||.|  |.|.. .|...||.|.|:.|:.
Human   475 ---LNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG--KSALD-NGPQIAYVRDFKAKVQ 533

  Fly   580 QFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFF 644
            .||:.||..|:|.||||||||:||||||:.|||.....:|||||::||.||||||||||:|||||
Human   534 YFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFF 598

  Fly   645 LLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPF 709
            |||||||||||||||||.|:||.||||||||:|||||:||:||||||||||:||:||.:||::||
Human   599 LLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 663

  Fly   710 YKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKER 774
            |||:|||.:.:||:|:|||||||||||||:|||:||.||::||||.|:||:|..|:||.||....
Human   664 YKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNIL 728

  Fly   775 VTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDW 839
            ||||||||||.::.|||::||:|:||:.|.|||||::|.::|:|||.:|||::|||||::|:.||
Human   729 VTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDW 793

  Fly   840 QRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEK 904
            ||:.|||||.|.|||::||||||:|.|||||.|||||||||||:||||||:||||||||:|||||
Human   794 QRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEK 858

  Fly   905 VGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||||.||||||||||||||||||||:||.|||.|||||||||.||
Human   859 VGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	42/127 (33%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	21/28 (75%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	19/31 (61%)
		HECTc	594..946	CDD:238033	262/351 (75%)
		HECTc	620..946	CDD:214523	245/325 (75%)
ITCH	NP_001244066.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	42/127 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..301		28/132 (21%)
		WW	328..357	CDD:306827	17/28 (61%)
		HUL4	<359..903	CDD:227354	367/555 (66%)
		Required for interaction with FYN. /evidence=ECO:0000269\|PubMed:16387660	395..471		36/80 (45%)
		MAP kinase docking site. /evidence=ECO:0000250	574..583		6/8 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I285
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	961	1.000	Inparanoid score	I330
Isobase	1	0.950	-	0	Normalized mean entropy	S744
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm41953
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.920