DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(dx) and ube3a

DIOPT Version :9

Sequence 1:NP_001259898.1 Gene:Su(dx) / 33379 FlyBaseID:FBgn0003557 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_001007319.1 Gene:ube3a / 792398 ZFINID:ZDB-GENE-041114-190 Length:857 Species:Danio rerio


Alignment Length:991 Identity:230/991 - (23%)
Similarity:392/991 - (39%) Gaps:272/991 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 GAGSASPTPTSSSGA---GASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELL-IDSKSKRKT 84
            ||.||.| ..|:.||   .|..:....:..|..|.|:  .|:..||..:...|:| |.|:::..:
Zfish    68 GASSAFP-ENSAKGAHNFSACSNGKMNHKDLPPTRED--FRDLNFLTEDKVYEILSICSETEDYS 129

  Fly    85 DLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELT 149
            .|::            |:....|:....|   .||||             ..||.....:.|:..
Zfish   130 PLIR------------VIGRVFSSAESLV---QSFRK-------------AKQHTKEELKSLQAK 166

  Fly   150 IDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQIQPVA------GQQNGNPPVQAVNPSVVS-D 207
            .:   ....|.::|.||...|           ::::|.|      |..:|...||.:.|..|| |
Zfish   167 DE---DKDEDEKETASGSSTA-----------MEVEPEASASSGDGSSHGENNVQKLGPVEVSVD 217

  Fly   208 AAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSPL----PNGGGD--HRRSTQAPP--------V 258
            ..|.|  .:|..:.:..::.::..|:        |    ||...|  :.....|.|        |
Zfish   218 IDAVR--RVYDRLLSNEKIEAAFLNA--------LVYLSPNVECDLTYHNVYAADPNYLNVFIIV 272

  Fly   259 WEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALAR--PLTQVYGA-----LPENTQPA 316
            .|.....|....:         .|:||......:.|.||||:  .|...||.     |.|..|..
Zfish   273 MENSNLHSPEYLE---------IALPQFCKAMSKLPLPALAKLARLWSQYGVDQIRRLVETFQQL 328

  Fly   317 AVYL--------------PAGGGAA------VGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPAD 361
            ..|.              ..|..||      |....|.|..::           ||   ..:..|
Zfish   329 ITYTVISNEFSSDNLVNEDDGVVAATKCLKIVYYANVLGGDLD-----------TD---HNEEDD 379

  Fly   362 DEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRP 426
            |||:|...|:.|.:     .:....|:....:..||.               .:...|.:..::|
Zfish   380 DEPIPESSELTLQE-----LLGEERRNKKGPRVDPLE---------------TEMGIRASDCRKP 424

  Fly   427 NSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDN 491
                |:.|:.:..:..:.|.:.::.|.:.                              |:::::
Zfish   425 ----LIPFEEFINEPLNEVLEMDKDYTFF------------------------------KVETES 455

  Fly   492 RVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGA 556
            :..|:.                         .|             |.::..|:..         
Zfish   456 KFSFMT-------------------------CP-------------FILNAVTKNL--------- 473

  Fly   557 PKGAKGVYGVPRAYERSFRW----KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MR 613
                 |:|     |:...|.    :::....|.|...|..::::.|.|..:.:|:..::    |.
Zfish   474 -----GLY-----YDNRIRMYSERRITALYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAME 528

  Fly   614 LPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNP 678
            .|| :|:::||:.|.||:|:|.||||:|:|.|:..|:.||...:|.| :::......||:|:.|.
Zfish   529 NPA-DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFENE 591

  Fly   679 DHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSL--IWVKDNN 741
            ..   |..||..:.:|:|:...:...|.|..|::::.||.|.:|:....|..:.||  :...:.|
Zfish   592 GQ---FTLIGIVLGLAIYNNCILDVHFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLMEYEGN 653

  Fly   742 IDECGLELWFSV-DFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLE 805
            ::| .:.:.|.: ..::.|..:.::|||:|:|..||.||:::::.|..|:.:.:.:|:|.|.|..
Zfish   654 VEE-DMMITFQISQTDLFGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAFRR 717

  Fly   806 GFNEVVPLEWLKY-FDERELELILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNE 868
            ||:.|.....||| |...|:||::||.:::|.:..:.:|.| ..||::|:.:..||:.|...:.|
Zfish   718 GFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQE 782

  Fly   869 KRARLLQFVTGTCRVPVGGFAEL---MGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYD 930
            |:...|||.|||.|.||||..:|   :..|||.         ...||.||||||.|.||.|.:.:
Zfish   783 KKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPD---------SDRLPTSHTCFNVLLLPEYSTVE 838

  Fly   931 QLVEKLTFAIEETEGF 946
            :|.|:|..||...:||
Zfish   839 KLKERLLKAITYAKGF 854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(dx)NP_001259898.1 C2_E3_ubiquitin_ligase 48..173 CDD:175988 26/125 (21%)
WW 364..396 CDD:197736 5/31 (16%)
WW 397..426 CDD:278809 2/28 (7%)
WW 478..509 CDD:197736 2/30 (7%)
WW 522..554 CDD:197736 3/31 (10%)
HECTc 594..946 CDD:238033 119/363 (33%)
HECTc 620..946 CDD:214523 112/333 (34%)
ube3aNP_001007319.1 AZUL 6..60 CDD:293166
HECTc 505..855 CDD:238033 121/365 (33%)
HECTc 532..854 CDD:214523 113/335 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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