Protein Alignment Su(dx) and ube3a

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001007319.1
• Gene: ube3a / 792398
• ZFINID: ZDB-GENE-041114-190
• Length: 857
• Species: Danio rerio
• Alignment Length: 991
• Identity: 230/991 - (23%)
• Similarity: 392/991 - (39%)
• Gaps: 272/991 - (27%)

  Fly    24 GAGSASPTPTSSSGA---GASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELL-IDSKSKRKT 84
            ||.||.| ..|:.||   .|..:....:..|..|.|:  .|:..||..:...|:| |.|:::..:
Zfish    68 GASSAFP-ENSAKGAHNFSACSNGKMNHKDLPPTRED--FRDLNFLTEDKVYEILSICSETEDYS 129

  Fly    85 DLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELT 149
            .|::            |:....|:....|   .||||             ..||.....:.|:..
Zfish   130 PLIR------------VIGRVFSSAESLV---QSFRK-------------AKQHTKEELKSLQAK 166

  Fly   150 IDLFVTSKSDNRQTKSGELVAILNGLKLDMSKLQIQPVA------GQQNGNPPVQAVNPSVVS-D 207
            .:   ....|.::|.||...|           ::::|.|      |..:|...||.:.|..|| |
Zfish   167 DE---DKDEDEKETASGSSTA-----------MEVEPEASASSGDGSSHGENNVQKLGPVEVSVD 217

  Fly   208 AAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSPL----PNGGGD--HRRSTQAPP--------V 258
            ..|.|  .:|..:.:..::.::..|:        |    ||...|  :.....|.|        |
Zfish   218 IDAVR--RVYDRLLSNEKIEAAFLNA--------LVYLSPNVECDLTYHNVYAADPNYLNVFIIV 272

  Fly   259 WEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALAR--PLTQVYGA-----LPENTQPA 316
            .|.....|....:         .|:||......:.|.||||:  .|...||.     |.|..|..
Zfish   273 MENSNLHSPEYLE---------IALPQFCKAMSKLPLPALAKLARLWSQYGVDQIRRLVETFQQL 328

  Fly   317 AVYL--------------PAGGGAA------VGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPAD 361
            ..|.              ..|..||      |....|.|..::           ||   ..:..|
Zfish   329 ITYTVISNEFSSDNLVNEDDGVVAATKCLKIVYYANVLGGDLD-----------TD---HNEEDD 379

  Fly   362 DEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRP 426
            |||:|...|:.|.:     .:....|:....:..||.               .:...|.:..::|
Zfish   380 DEPIPESSELTLQE-----LLGEERRNKKGPRVDPLE---------------TEMGIRASDCRKP 424

  Fly   427 NSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDN 491
                |:.|:.:..:..:.|.:.::.|.:.                              |:::::
Zfish   425 ----LIPFEEFINEPLNEVLEMDKDYTFF------------------------------KVETES 455

  Fly   492 RVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGA 556
            :..|:.                         .|             |.::..|:..
Zfish   456 KFSFMT-------------------------CP-------------FILNAVTKNL--------- 473

  Fly   557 PKGAKGVYGVPRAYERSFRW----KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MR 613
                 |:|     |:...|.    :::....|.|...|..::::.|.|..:.:|:..::    |.
Zfish   474 -----GLY-----YDNRIRMYSERRITALYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAME 528

  Fly   614 LPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNP 678
            .|| :|:::||:.|.||:|:|.||||:|:|.|:..|:.||...:|.| :::......||:|:.|.
Zfish   529 NPA-DLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFENE 591

  Fly   679 DHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSL--IWVKDNN 741
            ..   |..||..:.:|:|:...:...|.|..|::::.||.|.:|:....|..:.||  :...:.|
Zfish   592 GQ---FTLIGIVLGLAIYNNCILDVHFPMVIYRKLMGKKGTFRDLADSHPVLFQSLKDLMEYEGN 653

  Fly   742 IDECGLELWFSV-DFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLE 805
            ::| .:.:.|.: ..::.|..:.::|||:|:|..||.||:::::.|..|:.:.:.:|:|.|.|..
Zfish   654 VEE-DMMITFQISQTDLFGNPLMYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAFRR 717

  Fly   806 GFNEVVPLEWLKY-FDERELELILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNE 868
            ||:.|.....||| |...|:||::||.:::|.:..:.:|.| ..||::|:.:..||:.|...:.|
Zfish   718 GFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQE 782

  Fly   869 KRARLLQFVTGTCRVPVGGFAEL---MGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYD 930
            |:...|||.|||.|.||||..:|   :..|||.         ...||.||||||.|.||.|.:.:
Zfish   783 KKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPD---------SDRLPTSHTCFNVLLLPEYSTVE 838

  Fly   931 QLVEKLTFAIEETEGF 946
            :|.|:|..||...:||
Zfish   839 KLKERLLKAITYAKGF 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	26/125 (21%)
		WW	364..396	CDD:197736	5/31 (16%)
		HUL4	<395..946	CDD:227354	139/566 (25%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:465173
		HECTc	505..855	CDD:238033	121/365 (33%)