Protein Alignment Su(dx) and Smurf1

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_006504947.1
• Gene: Smurf1 / 75788
• MGIID: 1923038
• Length: 757
• Species: Mus musculus
• Alignment Length: 936
• Identity: 306/936 - (32%)
• Similarity: 449/936 - (47%)
• Gaps: 200/936 - (21%)

  Fly    34 SSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNE 97
            |:.|...:||:.:  .:|:|...:...:.:.|..|:|:.::::|...: ..||.|||:..||||:
Mouse     2 SNPGTRRNGSSIK--IRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQ 64

  Fly    98 EFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQ 162
            .:.:.:....::...|.:|....|..  |...:....:|                   |.:.:|.
Mouse    65 HYDLYVGKTDSITISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAISRL 108

  Fly   163 TKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLR 227
            ..:|.       .:||:.||                  ||| .:||..|:   |...::.|.|:
Mouse   109 KDTGY-------QRLDLCKL------------------NPS-DTDAVRGQ---IVVSLQTRDRI- 143

  Fly   228 SSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQ 292
              .|..:..:.|..|.|.|..:..|....|:       |...::|....:|:|||
Mouse   144 --GGGGSVVDCRGLLENEGTVYEDSGPGRPL-------SCLMEEPAPYTDGTGAA---------- 189

  Fly   293 PPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQT 357
                                         ||||..   ..|..|..:|   .|.|.:..:|:::.
Mouse   190 -----------------------------AGGGNC---RFVESPSQDQ---RLLVQRLRNPEVRG 219

  Fly   358 QPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTT 422
            .....:..|.|                       .:...||.|:|.|...:|:||::...|..:|
Mouse   220 PLQTPQNRPHG-----------------------HQSPELPEGYEQRTTVQGQVYFLHTQTGVST 261

  Fly   423 WQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKI 487
            |..|.....:          ..:..|::.:||....|..|:....:...:.|.|||||.|||.:.
Mouse   262 WHDPRIPSPL----------GTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRS 316

  Fly   488 QSDNRVYFVNHKNRTTQWEDPRTQ------------GQEVSLINEGPLPPGWEIRYTAAGERFFV 540
            ....|:|||:|.|||||:.|||..            .|.:.|.:||
Mouse   317 TVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEG------------------- 362

  Fly   541 DHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRY---LCQSNALPSHIKITVTRQT 602
                   :.||....|.:           |||....||...|:   |.|..|  .|.:|.|:|:.
Mouse   363 -------SVEDEELPAQR-----------YERDLVQKLKVLRHELSLQQPQA--GHCRIEVSREE 407

  Fly   603 LFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYS 667
            :||:||.|||::...:|::||.:.||||||||||||:|||.:||.||:|||.|.||:|:..|.|:
Mouse   408 IFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYT 472

  Fly   668 LQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYN 732
            |||||.|.:|||||.||.|:||.:.:|::||.:|..|||:||||::|.|.:.:.|:|::|||.:.
Mouse   473 LQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHK 537

  Fly   733 SLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIE 797
            ||:|:.:|:|... |:..|.|:....|:|:.||||.||....||||||:||:.|...||..||||
Mouse   538 SLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIE 601

  Fly   798 QQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFV 862
            .|.....:||||::|...||.||::|||||:.|:..:|:.||:.||..:|...:|..|.||||.|
Mouse   602 AQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAV 666

  Fly   863 RETDNEKRARLLQFVTGTCRVPVGGFAELMGSN---GPQRFCIEKVGKET-WLPRSHTCFNRLDL 923
            ...|.|:||||||||||:.|||:.||..|.||.   ||:.|.|..:...| .||::||||||:|:
Mouse   667 ETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDI 731

  Fly   924 PPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||:||::|.|||..|:|||.||..|
Mouse   732 PPYESYEKLYEKLLTAVEETCGFAVE 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	23/125 (18%)
		WW	364..396	CDD:197736	2/31 (6%)
		HUL4	<395..946	CDD:227354	238/569 (42%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028	34/175 (19%)
		WW	236..267	CDD:197736	12/30 (40%)
		WW	307..339	CDD:197736	18/31 (58%)
		HECTc	399..754	CDD:238033	182/355 (51%)