DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Smurf1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_006504947.1	Gene:	Smurf1 / 75788	MGIID:	1923038	Length:	757	Species:	Mus musculus

Alignment Length:	936	Identity:	306/936 - (32%)
Similarity:	449/936 - (47%)	Gaps:	200/936 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNE 97
            |:.|...:||:.:  .:|:|...:...:.:.|..|:|:.::::|...: ..||.|||:..||||:
Mouse     2 SNPGTRRNGSSIK--IRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQ 64

  Fly    98 EFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQ 162
            .:.:.:....::...|.:|....|..  |...:....:|                   |.:.:|.
Mouse    65 HYDLYVGKTDSITISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAISRL 108

  Fly   163 TKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLR 227
            ..:|.       .:||:.||                  ||| .:||..|:   |...::.|.|:
Mouse   109 KDTGY-------QRLDLCKL------------------NPS-DTDAVRGQ---IVVSLQTRDRI- 143

  Fly   228 SSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQ 292
              .|..:..:.|..|.|.|..:..|....|:       |...::|....:|:|||
Mouse   144 --GGGGSVVDCRGLLENEGTVYEDSGPGRPL-------SCLMEEPAPYTDGTGAA---------- 189

  Fly   293 PPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQT 357
                                         ||||..   ..|..|..:|   .|.|.:..:|:::.
Mouse   190 -----------------------------AGGGNC---RFVESPSQDQ---RLLVQRLRNPEVRG 219

  Fly   358 QPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTT 422
            .....:..|.|                       .:...||.|:|.|...:|:||::...|..:|
Mouse   220 PLQTPQNRPHG-----------------------HQSPELPEGYEQRTTVQGQVYFLHTQTGVST 261

  Fly   423 WQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKI 487
            |..|.....:          ..:..|::.:||....|..|:....:...:.|.|||||.|||.:.
Mouse   262 WHDPRIPSPL----------GTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRS 316

  Fly   488 QSDNRVYFVNHKNRTTQWEDPRTQ------------GQEVSLINEGPLPPGWEIRYTAAGERFFV 540
            ....|:|||:|.|||||:.|||..            .|.:.|.:||
Mouse   317 TVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEG------------------- 362

  Fly   541 DHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRY---LCQSNALPSHIKITVTRQT 602
                   :.||....|.:           |||....||...|:   |.|..|  .|.:|.|:|:.
Mouse   363 -------SVEDEELPAQR-----------YERDLVQKLKVLRHELSLQQPQA--GHCRIEVSREE 407

  Fly   603 LFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYS 667
            :||:||.|||::...:|::||.:.||||||||||||:|||.:||.||:|||.|.||:|:..|.|:
Mouse   408 IFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYT 472

  Fly   668 LQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYN 732
            |||||.|.:|||||.||.|:||.:.:|::||.:|..|||:||||::|.|.:.:.|:|::|||.:.
Mouse   473 LQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHK 537

  Fly   733 SLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIE 797
            ||:|:.:|:|... |:..|.|:....|:|:.||||.||....||||||:||:.|...||..||||
Mouse   538 SLVWILENDITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIE 601

  Fly   798 QQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFV 862
            .|.....:||||::|...||.||::|||||:.|:..:|:.||:.||..:|...:|..|.||||.|
Mouse   602 AQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAV 666

  Fly   863 RETDNEKRARLLQFVTGTCRVPVGGFAELMGSN---GPQRFCIEKVGKET-WLPRSHTCFNRLDL 923
            ...|.|:||||||||||:.|||:.||..|.||.   ||:.|.|..:...| .||::||||||:|:
Mouse   667 ETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDI 731

  Fly   924 PPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||:||::|.|||..|:|||.||..|
Mouse   732 PPYESYEKLYEKLLTAVEETCGFAVE 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	23/125 (18%)
		WW	364..396	CDD:197736	2/31 (6%)
		WW	397..426	CDD:278809	11/28 (39%)
		WW	478..509	CDD:197736	17/30 (57%)
		WW	522..554	CDD:197736	2/31 (6%)
		HECTc	594..946	CDD:238033	182/355 (51%)
		HECTc	620..946	CDD:214523	171/329 (52%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028	34/175 (19%)
		WW	236..267	CDD:197736	12/30 (40%)
		WW	307..339	CDD:197736	18/31 (58%)
		HECTc	399..754	CDD:238033	182/355 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750