Protein Alignment Su(dx) and hace1

DIOPT Version :9

• Sequence 1: NP_001259898.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_012818577.2
• Gene: hace1 / 734146
• XenbaseID: XB-GENE-5757512
• Length: 1012
• Species: Xenopus tropicalis
• Alignment Length: 1020
• Identity: 273/1020 - (26%)
• Similarity: 404/1020 - (39%)
• Gaps: 254/1020 - (24%)

  Fly    78 SKSKRKTDLVKNSYLPKWNEEFTVLITP-------NSTLHFKVLDHSSFRKDAMLGERIINLAHI 135
            ::|.|:...|:   ||:.||.....:.|       .|.|  ::|.:|.|..:...|....:|.||
 Frog    80 TRSLRRARTVE---LPEDNETAVYTLMPMVMADQHRSVL--ELLSNSKFDVNYAFGRVKRSLLHI 139

  Fly   136 LQHYNGRCEFLELTIDLFVTSKSDNRQTKSGEL---VAILNGLKLDMSKLQIQPVAGQQNGNPPV 197
            .    ..|..:|..:.|.......|.|..||..   :|..||.|..||||...........|..:
 Frog   140 A----ANCGSVECLVLLLKRGADPNYQDISGCTPLHLAARNGQKKCMSKLLEYNADVNICNNEGL 200

  Fly   198 QAVNPSVVSDAAAGRSCMIYGGVR--ARMRLRSSSGNS-------NGGETR-SPLPNGGGDHRRS 252
            .|::...|:    ||:.:::..|:  ..:.:..:.|.:       ||.:|. ..|.:.|.|..|.
 Frog   201 TAIHWLAVN----GRTELLHDLVQHVTNVDVEDAMGQTALHVACQNGHKTTVLCLLDSGADINRP 261

  Fly   253 TQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQP-- 315
                                    |.|||                     |.:|.|.....:.
 Frog   262 ------------------------NVSGA---------------------TPLYFACSHGQRDTA 281

  Fly   316 ------AAVYLPAGGGAAVGPPGVAGPPIE---QPGVGLPVSQSTDPQLQTQP---------ADD 362
                  .|.|||...|..         |::   |.|.|    ::.|..:|..|         ..:
 Frog   282 QILLLRGAKYLPDKNGVT---------PLDLCVQGGYG----ETCDILIQHHPRLFQTLIQMTQN 333

  Fly   363 EPLPAGWEIR-----LDQYGRRYYVDHNT-----RSTYWEKPTPLPPGWEIRKDGRGRVYYVDHN 417
            |.|... .:|     |.|.....|:...|     .:|...|...:...:|.:.....|:..:..:
 Frog   334 EDLREN-TLRQVLEHLSQQSEVQYLKILTGLAEVATTNGHKLLSISSSYEAQMKSLLRIVRIFCH 397

  Fly   418 TRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQ----RYLYSQQQQQPT-AVTAQVT--QDDEDA 475
            ..:.....||:...|.:...:..|..|....|.    |.:..::...|. .:..|.|  ||..:.
 Frog   398 VFRIGPSSPNNGNDMGYNGNKTPRNQVFKVRNVYDVFRKINIKEMNLPNHTLIYQATSEQDPLEL 462

  Fly   476 LGPLPDGW---------EKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRY 531
            |....|.|         :.|..|.|....:..:|:..|        |::||.::
 Frog   463 LWHSLDEWLVLIATELTKNKRDSSNIACILLKQNQLDQ--------QDISLAHQ----------- 508

  Fly   532 TAAGERFFVDH---NTRRTTFED------PRPGA----------------------------PKG 559
            :|.||....||   :||...||.      ..|.|                            |:|
 Frog   509 SAIGESGSYDHLSSSTRAEDFESCSAAGKQEPVADGQDVISMTANRLSAVIQAFYMCCSCQMPQG 573

  Fly   560 AKGVYGVPRAYE--------------RSFRWKLSQFRYLCQSNALPS---HI------------- 594
            ...    ||..|              |:.:.....|.:|.:...|.|   ||
 Frog   574 MTS----PRFIEFVCKHDDVLKCFVTRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKERCEWF 634

  Fly   595 ----------------------KITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGG 637
                                  .:.|.|.::|..|...:.:....:|::.:.:.|.||||:.. |
 Frog   635 YEHLLAGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVFKSNCEKLKQGIAVRFHGEEGMGQ-G 698

  Fly   638 VSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIY 702
            |.||||.:||.|::||.|.||. .:.:..:.|.|..|.||||||.||:|.|..:.:||||.:.:.
 Frog   699 VVREWFDILSSEIINPDYALFT-QSADGTTFQPNSNSSVNPDHLNYFRFAGEILGLALYHRQLVN 762

  Fly   703 SGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELK 767
            ..||..|||.:|...:..:|:.:||||:..:|.|:.||:|.:.||||.|||:.:|.|.:....||
 Frog   763 IYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLK 827

  Fly   768 ENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQ 832
            ..|....||:|||.||:.|:||.||||.|:.|...||:||:..:|...::.|||.||||:|.||.
 Frog   828 PGGASILVTQENKAEYVQLVTELRMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMP 892

  Fly   833 DVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNG 896
            ::||.||.:||.|.. |.|:.:.:.|||:.|:|...|:|..|||||||:.|||.||||.:||.:|
 Frog   893 EIDVNDWMKNTEYTSGYERDDQVIQWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSG 957

  Fly   897 PQRFCIEKVG-KETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAI 940
            .|.|.|..|. ....||.|.||.|.|.||.|.|.:.|.::|..|:
 Frog   958 LQNFTIAAVAYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	25/104 (24%)
		WW	364..396	CDD:197736	8/41 (20%)
		WW	397..426	CDD:278809	2/28 (7%)
		WW	478..509	CDD:197736	7/39 (18%)
		WW	522..554	CDD:197736	9/40 (23%)
		HECTc	594..946	CDD:238033	152/384 (40%)
		HECTc	620..946	CDD:214523	146/323 (45%)
hace1	XP_012818577.2	PLN03192	<19..289	CDD:215625	53/266 (20%)
		ANK repeat	134..163	CDD:293786	7/32 (22%)
		ANKYR	<160..288	CDD:223738	33/176 (19%)
		ANK repeat	165..196	CDD:293786	10/30 (33%)
		ANK repeat	198..229	CDD:293786	5/34 (15%)
		ANK repeat	231..262	CDD:293786	8/54 (15%)
		ANK repeat	264..289	CDD:293786	6/45 (13%)
		HECTc	657..1006	CDD:238033	151/348 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910