DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(dx) and UBE3A

DIOPT Version :9

Sequence 1:NP_001259898.1 Gene:Su(dx) / 33379 FlyBaseID:FBgn0003557 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_000453.2 Gene:UBE3A / 7337 HGNCID:12496 Length:875 Species:Homo sapiens


Alignment Length:516 Identity:155/516 - (30%)
Similarity:254/516 - (49%) Gaps:77/516 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   470 QDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSL----------------- 517
            :|||:   |:|:..|..:|.     .:..:.|..  :.||....|..|                 
Human   395 EDDEE---PIPESSELTLQE-----LLGEERRNK--KGPRVDPLETELGVKTLDCRKPLIPFEEF 449

  Fly   518 INEGPLPPGWEI--RYTAAGERFFVDHNTRRTTFEDPRP---GAPKGAKGVYGVPRAYERSFRW- 576
            ||| ||....|:  .||     ||......:.:|. ..|   .|.....|:|     |:...|. 
Human   450 INE-PLNEVLEMDKDYT-----FFKVETENKFSFM-TCPFILNAVTKNLGLY-----YDNRIRMY 502

  Fly   577 ---KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MRLPAYELRRRLYIIFRGEEGLD 634
               :::....|.|...|..::::.|.|..:.:|:..::    |..|| :|:::||:.|.||:|:|
Human   503 SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA-DLKKQLYVEFEGEQGVD 566

  Fly   635 YGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGR 699
            .||||:|:|.|:..|:.||...:|.| :::......||:|:.....   |..||..:.:|:|:..
Human   567 EGGVSKEFFQLVVEEIFNPDIGMFTY-DESTKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNC 627

  Fly   700 FIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKD-----NNIDECGLELWFSV-DFEVL 758
            .:...|.|..|::::.||.|.:|:....|..|.||   ||     .|::: .:.:.|.: ..::.
Human   628 ILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSL---KDLLEYEGNVED-DMMITFQISQTDLF 688

  Fly   759 GQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY-FDER 822
            |..:.::|||||:|..:|.||::|::.|.:::.:.:.:|:|.|.|..||:.|.....||| |...
Human   689 GNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPE 753

  Fly   823 ELELILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVG 886
            |:||::||.:::|.:..:..|.| ..|.|:|..:..||:.|....:|::...|||.|||.|.|||
Human   754 EIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG 818

  Fly   887 GFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |..:|       :..|.|.|.:| .||.||||||.|.||.|.|.::|.|:|..||...:||
Human   819 GLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGF 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(dx)NP_001259898.1 C2_E3_ubiquitin_ligase 48..173 CDD:175988
WW 364..396 CDD:197736
WW 397..426 CDD:278809
WW 478..509 CDD:197736 5/30 (17%)
WW 522..554 CDD:197736 8/33 (24%)
HECTc 594..946 CDD:238033 121/364 (33%)
HECTc 620..946 CDD:214523 114/334 (34%)
UBE3ANP_000453.2 AZUL 29..83 CDD:406862
HECTc 523..873 CDD:238033 123/366 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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