DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Ubr5

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_006520242.1	Gene:	Ubr5 / 70790	MGIID:	1918040	Length:	2800	Species:	Mus musculus

Alignment Length:	788	Identity:	169/788 - (21%)
Similarity:	279/788 - (35%)	Gaps:	207/788 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 QQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGG 325
            |.:|:.:.::|.| :...:.::.|       .|.||.:|..|            .:::....|..
Mouse  2115 QNRQKKEGEEQSL-LAEEADSSKP-------GPSAPDVAAQL------------KSSLLAEIGLT 2159

  Fly   326 AAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTY 390
            .:.|||..:..| :...:|:.:|.             :.|...|.:.|:.:||.:..|....
Mouse  2160 ESEGPPLTSFRP-QCSFMGMVISH-------------DMLLGRWRLSLELFGRVFMEDVGAE--- 2207

  Fly   391 WEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYS 455
                    ||..:.:.|...|        |.:..|...|:|.: |..:.....|....::..|..
Mouse  2208 --------PGSILTELGGFEV--------KESKFRREMEKLRN-QQSRDLSLEVKVDRDRDLLIQ 2255

  Fly   456 QQQQQ------------PTAV-TAQVTQDDEDALGPLPDGWEKKIQSD-NRVYFVNHKNRTTQWE 506
            |..:|            |.|| ..:||..||...|   .|..:...:. .:.:..|.|.......
Mouse  2256 QTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEG---SGVARSFYTAIAQAFLSNEKLPNLDCI 2317

  Fly   507 DPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYE 571
            ....:|...||:.          |....|||   |....|........|...|::      |..:
Mouse  2318 QNANKGTHTSLMQ----------RLRNRGER---DREREREREMRRSSGLRAGSR------RDRD 2363

  Fly   572 RSFRWKLS----QFRYLCQSN------ALPSHIKITVTRQTLFEDSYHQIMRL-PAY-------- 617
            |.||.:||    .||...:.|      .||:|      ||.|.|..|.::..: ||:
Mouse  2364 RDFRRQLSIDTRPFRPASEGNPSDDPDPLPAH------RQALGERLYPRVQAMQPAFASKITGML 2422

  Fly   618 ----------------ELRRRL-----YIIFRGEEG-----LDYG---------------GVSRE 641
                            .||.|:     .||..|.|.     ||.|               |.||.
Mouse  2423 LELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQENRKRHGSSRS 2487

  Fly   642 WFFLLSHEVLN--------PMYCLFEYANKNNYSLQINPASYVNPD-HLQYFKFIGRFIAMALYH 697
               ::..::.:        |::  ::...:..|:    |....|.: .|..|:.|||.:.:.|..
Mouse  2488 ---VVDMDLEDTDDGDDNAPLF--YQPGKRGFYT----PRPGKNTEARLNCFRNIGRILGLCLLQ 2543

  Fly   698 GRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSL----IWVKDNNIDE--CGLELWFSVDF- 755
            .............|.:|.:|:...|....||..|.||    :..:.::.|.  ..::|.|::|.
Mouse  2544 NELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLC 2608

  Fly   756 --EVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY 818
              |..||:   ||..||....||.:|..||:....|.||....||......:|..:|:|...|:.
Mouse  2609 KEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLED 2670

  Fly   819 FDERELELILCGMQDVDVEDWQRNTIYRHYN----RNSKQVV----WFWQFVRETDNEKRARLLQ 875
            ....:..|::.|..:|:|   |....:..:|    .|:::::    |||..|.:....:|..|:.
Mouse  2671 LTAEDFRLLVNGCGEVNV---QMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVY 2732

  Fly   876 FVTGTCRVPVG--GFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTF 938
            |.|.:..:|..  ||.       |......:...:..||.::||.:||.:|.|.|...|.:||..
Mouse  2733 FWTSSPSLPASEEGFQ-------PMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLL 2790

  Fly   939 AIEETEGF 946
            || :|:.|
Mouse  2791 AI-KTKNF 2797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	6/31 (19%)
		WW	397..426	CDD:278809	5/28 (18%)
		WW	478..509	CDD:197736	3/31 (10%)
		WW	522..554	CDD:197736	6/31 (19%)
		HECTc	594..946	CDD:238033	98/429 (23%)
		HECTc	620..946	CDD:214523	90/378 (24%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	15/68 (22%)
		HECTc	2469..2797	CDD:214523	81/350 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900