Protein Alignment Su(dx) and Herc4

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_084390.1
• Gene: Herc4 / 67345
• MGIID: 1914595
• Length: 1057
• Species: Mus musculus
• Alignment Length: 530
• Identity: 128/530 - (24%)
• Similarity: 239/530 - (45%)
• Gaps: 63/530 - (11%)

  Fly   426 PNSERLM--HFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQ 488
            |.|||.:  .|.|...:...::.:.|::             |.|:.|.|:..:..:.:
Mouse   579 PPSERRIFNSFLHTALKVLEILHRVNEK-------------TGQLIQYDKFYIHEVQE------- 623

  Fly   489 SDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR 553
                  .::.:|....|...:..|.:||   .|..... :|..|.....|..|...:.|..:
Mouse   624 ------LIDIRNDYINWVQQQAYGVDVS---HGVTELA-DIPVTICTYPFVFDAQAKTTLLQ--- 675

  Fly   554 PGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYE 618
                  ...|..:..|.:::.|..:|.. :|....::...:.:.|.|:.:..|:...:.:....:
Mouse   676 ------TDAVLQMQMAIDQAHRQNVSSL-FLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNID 733

  Fly   619 LRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQY 683
            .::.|.:||.||:.:|.|||.:|:|.|:..|:|:|.|.:|.| .:::..:..:..::.:.|   .
Mouse   734 YKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFEDSD---L 794

  Fly   684 FKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNS---LIWVKDNNIDE- 744
            |..||....:|:|:...:...|.:..||::|.:|.::.|::.:.|....|   |:...:::|:|
Mouse   795 FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEET 859

  Fly   745 -CGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFN 808
             |   |.|::..|..|.....||..||....|..:|::|::....::...:.:......|..||:
Mouse   860 FC---LNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFH 921

  Fly   809 EVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRAR 872
            :|...:.|..|...||:.::.|..:.|.::.::||.|: .|..:...:..||:...|...||:.:
Mouse   922 KVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQ 986

  Fly   873 LLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKV-GKETWLPRSHTCFNRLDLPPYKSYDQLVEKL 936
            .|.|:||:.|:|:.|...|       :..|:.. |.|::||.||||||.||||.|...:.|..||
Mouse   987 FLLFLTGSDRIPILGMKSL-------KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKL 1044

  Fly   937 TFAIEETEGF 946
            ..||:..|||
Mouse  1045 IQAIDHNEGF 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		HUL4	<395..946	CDD:227354	126/528 (24%)
Herc4	NP_084390.1	RCC1 1	1..51
		ATS1	3..338	CDD:444065
		RCC1 2	52..101
		RCC1 3	102..154
		RCC1 4	156..207
		RCC1 5	208..259
		RCC1 6	261..311
		RCC1 7	313..366
		HECTc	709..1055	CDD:238033	101/360 (28%)