DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Herc6

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_080268.1	Gene:	Herc6 / 67138	MGIID:	1914388	Length:	1003	Species:	Mus musculus

Alignment Length:	435	Identity:	109/435 - (25%)
Similarity:	203/435 - (46%)	Gaps:	40/435 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 YTAAGERFFVDHNTRRTT-------FEDPRPGAPKGAKGVYGVPRAYE----RSFRWKLSQFRYL 584
            :.|...|.|:.||....|       |.|        ...|:.:|...:    .||...:|:....
Mouse   592 FDAEAGRMFIRHNDLDCTESSDMVVFSD--------FLFVFDLPSKIKLMKCDSFVKLMSEVMAF 648

  Fly   585 CQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHE 649
            .:..:.|.::.:.|.|..|.||:..|:.::..::||::|.:.|..|...:.||||.|:|..:..|
Mouse   649 PEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEIRPEAGGVSSEFFHCIFEE 713

  Fly   650 VLNPMYCLFEYANK-NNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRM 713
            :.:|.|.:|.|..| ::....:||..    :...||.| |....::|::.:.|...|.:..||::
Mouse   714 MTDPKYEMFIYPEKGSSMWFPVNPKF----EKSSYFLF-GILCGLSLHNLKVINLPFPLALYKKL 773

  Fly   714 LNKKLTIKDIETIDPEFYNSLIWV---KDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERV 775
            ||:|.:::|::.:......:|..|   :..:|:|  |.::||:.::....    :|..:|....|
Mouse   774 LNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEE--LHMYFSIYWDQKDV----DLIPDGISVPV 832

  Fly   776 TEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQ 840
            .|.||.:|::...::.....|:...:.|..||.:|...:.::.|...||...:.|....|.:.::
Mouse   833 NETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFE 897

  Fly   841 RNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEK 904
            .|:.|:. |:::...::.||:...:...:::.:.|.|:||..|:.|.|    :.:.|....|.|.
Mouse   898 NNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKG----LQNEGIVFRCSET 958

  Fly   905 VGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ..:|. .|||.||...||||.|.|..::.|.|..||..:.||..:
Mouse   959 FSEED-NPRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGFVSQ 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736	8/29 (28%)
		HECTc	594..946	CDD:238033	93/356 (26%)
		HECTc	620..946	CDD:214523	86/330 (26%)
Herc6	NP_080268.1	RCC1 1	40..91
		RCC1	40..89	CDD:278826
		RCC1 2	92..144
		RCC1	92..142	CDD:278826
		RCC1	145..195	CDD:278826
		RCC1 3	146..197
		RCC1_2	183..211	CDD:290274
		RCC1 4	199..252
		RCC1_2	237..266	CDD:290274
		RCC1 5	253..303
		RCC1	253..300	CDD:278826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281
		chaperonin_like	<570..>652	CDD:295468	13/67 (19%)
		HECTc	658..999	CDD:238033	93/356 (26%)
		HECTc	682..999	CDD:214523	87/332 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810