DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Wwp2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	941	Identity:	501/941 - (53%)
Similarity:	621/941 - (65%)	Gaps:	100/941 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKP--NPYVELLID---SKSKRKTDLVKNSYLP 93
            |||.||.:....:....|.|...:..:.|.   :|  |.|||:.:|   |::|:....:.:|.|
Mouse     5 SSSRAGVALPFEKSQLTLKVVSAKPKVHNR---QPRINSYVEVAVDGLPSETKKTGKRIGSSEL- 65

  Fly    94 KWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKS 158
            .|||...:.:|..|.|..||....:.|.: :||...:||:::|::..|:.|..:||::|...:|.
Mouse    66 LWNEIIVLNVTAQSHLDLKVWSCHTLRNE-LLGTASVNLSNVLKNNGGKMENTQLTLNLQTENKG 129

  Fly   159 DNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRAR 223
            .  ....|||...|:|..:|:             |:.|    |.|.|:|.:...|
Mouse   130 S--VVSGGELTIFLDGPTVDL-------------GSVP----NGSAVTDGSQPPS---------- 165

  Fly   224 MRLRSSSGNSNGGETRSPLP-------------NGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRM 275
               |.|||.:...|||...|             :.||..|.:|.|.   ||........:||::.
Mouse   166 ---RESSGTAIAPETRHQPPSTNCFGGRSRTHRHSGGSARTATAAS---EQSPGARNRHRQPVKN 224

  Fly   276 VNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAV-YLPAGGGAAVGPPGVAGPPIE 339
            .:.||.|....    .:.|.||          :.||.:....| .|||...:....|.....|.:
Mouse   225 SSSSGLANGTV----NEEPTPA----------SEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQ 275

  Fly   340 Q-PGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEI 403
            . |..|...|.|...||.......:.||||||.|....||.|||||||::|.||:  |||||||.
Mouse   276 STPAEGEEASTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWER--PLPPGWEK 338

  Fly   404 RKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQG-----NQRYLYSQQQQQPTA 463
            |.|.|||.||||||||.||||||.:|.:.:::.||.||..:  ||     :||:||    |..:|
Mouse   339 RTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQL--QGAMQHFSQRFLY----QSSSA 397

  Fly   464 VTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWE 528
            .|      |.|.|||||.||||: |.:.|||:|||..||||||||||||    :|.|..||||||
Mouse   398 ST------DHDPLGPLPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQG----MIQEPALPPGWE 451

  Fly   529 IRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSH 593
            ::||:.|.|:|||||||.|||:|||||...|.|  .|.|.||:||||||..|||:||.|||||||
Mouse   452 MKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTK--QGSPGAYDRSFRWKYHQFRFLCHSNALPSH 514

  Fly   594 IKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLF 658
            :||:|:||||||||:.|||.:..|:||||||||.||||||||||::|||||||||||||||||||
Mouse   515 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLF 579

  Fly   659 EYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDI 723
            |||.||||.|||||||.:|||||.||:|||||||||||||:||.:|||:|||||||||:.|:||:
Mouse   580 EYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDL 644

  Fly   724 ETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMT 788
            |:||||||||::|:|:||::||||||:|..|.|:||::..|||||.||..|||||||||||.|:|
Mouse   645 ESIDPEFYNSIVWIKENNLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLT 709

  Fly   789 EWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSK 853
            :||.|||:|:|||.||:|||||.|||||:||||:||||:|||||::|:.|||:|.|||||.::||
Mouse   710 DWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSK 774

  Fly   854 QVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCF 918
            |:.||||.|:|.|||||.|||||||||||:||||||||:||||||:|||::||||||||||||||
Mouse   775 QIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCF 839

  Fly   919 NRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||||||||||:||.|||.:||||||||.||
Mouse   840 NRLDLPPYKSYEQLKEKLLYAIEETEGFGQE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	36/129 (28%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	23/28 (82%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	22/31 (71%)
		HECTc	594..946	CDD:238033	269/351 (77%)
		HECTc	620..946	CDD:214523	253/325 (78%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	36/131 (27%)
		PRK07003	<149..>299	CDD:235906	44/183 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300		43/183 (23%)
		WW	302..331	CDD:366073	19/30 (63%)
		WW	332..361	CDD:366073	23/28 (82%)
		WW	407..435	CDD:366073	19/28 (68%)
		WW	447..477	CDD:238122	21/29 (72%)
		HECTc	516..868	CDD:238033	270/351 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I292
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	973	1.000	Inparanoid score	I318
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm44001
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870