DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Smurf2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_079757.2	Gene:	Smurf2 / 66313	MGIID:	1913563	Length:	748	Species:	Mus musculus

Alignment Length:	940	Identity:	317/940 - (33%)
Similarity:	441/940 - (46%)	Gaps:	228/940 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GSANQGYHQLSVTIEEAS--LRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVLI 103
            |....|..:|.:|:..|.  ::.:.|..|:|:.::::|...: ..||.|||:..||||:.:.:.|
Mouse     5 GGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYI 69

  Fly   104 TPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGEL 168
            ..:.::...|.:|....|..  |...:....:|                   |.:.||...:|.
Mouse    70 GKSDSVTISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAINRLKDTGY- 112

  Fly   169 VAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNS 233
                  .:||:.||       ..|.|..|:.               .|...:::|.|:
Mouse   113 ------QRLDLCKL-------GPNDNDTVRG---------------QIVVSLQSRDRI------- 142

  Fly   234 NGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPAL 298
                                                        |:|..|
Mouse   143 --------------------------------------------GTGGQV--------------- 148

  Fly   299 ARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDE 363
                                                                    :......|.
Mouse   149 --------------------------------------------------------VDCSRLFDN 157

  Fly   364 PLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNS 428
            .||.|||.|....||..|::|.||:|.||:||  .|..|....||....:||.||..|   ..|.
Mouse   158 DLPDGWEERRTASGRIQYLNHITRTTQWERPT--RPASEYSSPGRPLSCFVDENTPIT---GTNG 217

  Fly   429 ERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRV 493
            ....|....:.....|.||.::.|:.......|.               .||:|:|::.....:|
Mouse   218 ATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRTTQQGQV 267

  Fly   494 YFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR-- 553
            ||::.:...:.|.|||.. :::|.||   .||||||||||.||.|..:|||||.|.|.|.|||
Mouse   268 YFLHTQTGVSTWHDPRVP-RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLS 331

  Fly   554 ----------------------PGAPKGAKGVYGVPRAYERSFRWKLSQFRY-LCQSNALPSHIK 595
                                  |..|...: ...||| |:|....||...|. |.|......|.:
Mouse   332 ANLHLVLNRQNQLKDQQQQQVVPLCPDDTE-CLTVPR-YKRDLVQKLKILRQELSQQQPQAGHCR 394

  Fly   596 ITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEY 660
            |.|:|:.:||:||.|:|::...:|.:||.|.||||||||||||:|||.:|||||:|||.|.||:|
Mouse   395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQY 459

  Fly   661 ANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725
            :..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||:||||::|.|.:|:.|:|.
Mouse   460 SRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMEL 524

  Fly   726 IDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEW 790
            :||:.:|||:|:.:|:|... |:..|.|:....|:||.||||.||:...||||||:||:.|...|
Mouse   525 VDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNW 588

  Fly   791 RMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQV 855
            |..||||.|.....:|||||:|...||.|||:|||||:||:..:||.||:.||..:|...:|..|
Mouse   589 RFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVV 653

  Fly   856 VWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFN 919
            .|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.|.::...| .||::|||||
Mouse   654 KWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFN 718

  Fly   920 RLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |:|:|||:||::|.|||..|||||.||..|
Mouse   719 RIDIPPYESYEKLYEKLLTAIEETCGFAVE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	26/127 (20%)
		WW	364..396	CDD:197736	16/31 (52%)
		WW	397..426	CDD:278809	9/28 (32%)
		WW	478..509	CDD:197736	9/30 (30%)
		WW	522..554	CDD:197736	23/55 (42%)
		HECTc	594..946	CDD:238033	188/352 (53%)
		HECTc	620..946	CDD:214523	178/326 (55%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028	34/173 (20%)
		WW	159..188	CDD:278809	15/28 (54%)
		WW	252..283	CDD:197736	9/30 (30%)
		WW	298..330	CDD:197736	22/31 (71%)
		HECTc	393..745	CDD:238033	188/352 (53%)
		HECTc	420..745	CDD:214523	178/325 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750