Protein Alignment Su(dx) and Smurf2

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_079757.2
• Gene: Smurf2 / 66313
• MGIID: 1913563
• Length: 748
• Species: Mus musculus
• Alignment Length: 940
• Identity: 317/940 - (33%)
• Similarity: 441/940 - (46%)
• Gaps: 228/940 - (24%)

  Fly    42 GSANQGYHQLSVTIEEAS--LRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVLI 103
            |....|..:|.:|:..|.  ::.:.|..|:|:.::::|...: ..||.|||:..||||:.:.:.|
Mouse     5 GGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYI 69

  Fly   104 TPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGEL 168
            ..:.::...|.:|....|..  |...:....:|                   |.:.||...:|.
Mouse    70 GKSDSVTISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAINRLKDTGY- 112

  Fly   169 VAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNS 233
                  .:||:.||       ..|.|..|:.               .|...:::|.|:
Mouse   113 ------QRLDLCKL-------GPNDNDTVRG---------------QIVVSLQSRDRI------- 142

  Fly   234 NGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPAL 298
                                                        |:|..|
Mouse   143 --------------------------------------------GTGGQV--------------- 148

  Fly   299 ARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDE 363
                                                                    :......|.
Mouse   149 --------------------------------------------------------VDCSRLFDN 157

  Fly   364 PLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNS 428
            .||.|||.|....||..|::|.||:|.||:||  .|..|....||....:||.||..|   ..|.
Mouse   158 DLPDGWEERRTASGRIQYLNHITRTTQWERPT--RPASEYSSPGRPLSCFVDENTPIT---GTNG 217

  Fly   429 ERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRV 493
            ....|....:.....|.||.::.|:.......|.               .||:|:|::.....:|
Mouse   218 ATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRTTQQGQV 267

  Fly   494 YFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR-- 553
            ||::.:...:.|.|||.. :::|.||   .||||||||||.||.|..:|||||.|.|.|.|||
Mouse   268 YFLHTQTGVSTWHDPRVP-RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLS 331

  Fly   554 ----------------------PGAPKGAKGVYGVPRAYERSFRWKLSQFRY-LCQSNALPSHIK 595
                                  |..|...: ...||| |:|....||...|. |.|......|.:
Mouse   332 ANLHLVLNRQNQLKDQQQQQVVPLCPDDTE-CLTVPR-YKRDLVQKLKILRQELSQQQPQAGHCR 394

  Fly   596 ITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEY 660
            |.|:|:.:||:||.|:|::...:|.:||.|.||||||||||||:|||.:|||||:|||.|.||:|
Mouse   395 IEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQY 459

  Fly   661 ANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725
            :..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||:||||::|.|.:|:.|:|.
Mouse   460 SRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMEL 524

  Fly   726 IDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEW 790
            :||:.:|||:|:.:|:|... |:..|.|:....|:||.||||.||:...||||||:||:.|...|
Mouse   525 VDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNW 588

  Fly   791 RMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQV 855
            |..||||.|.....:|||||:|...||.|||:|||||:||:..:||.||:.||..:|...:|..|
Mouse   589 RFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVV 653

  Fly   856 VWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFN 919
            .|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.|.::...| .||::|||||
Mouse   654 KWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFN 718

  Fly   920 RLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |:|:|||:||::|.|||..|||||.||..|
Mouse   719 RIDIPPYESYEKLYEKLLTAIEETCGFAVE 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	26/127 (20%)
		WW	364..396	CDD:197736	16/31 (52%)
		HUL4	<395..946	CDD:227354	256/579 (44%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028	34/173 (20%)
		HUL4	<159..745	CDD:227354	272/609 (45%)