DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and SMURF2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_073576.1	Gene:	SMURF2 / 64750	HGNCID:	16809	Length:	748	Species:	Homo sapiens

Alignment Length:	945	Identity:	316/945 - (33%)
Similarity:	441/945 - (46%)	Gaps:	238/945 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GSANQGYHQLSVTIEEAS--LRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVLI 103
            |....|..:|.:|:..|.  ::.:.|..|:|:.::::|...: ..||.|||:..||||:.:.:.|
Human     5 GGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYI 69

  Fly   104 TPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGEL 168
            ..:.::...|.:|....|..  |...:....:|                   |.:.||...:|.
Human    70 GKSDSVTISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAINRLKDTGY- 112

  Fly   169 VAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNS 233
                  .:||:.||       ..|.|..|:.               .|...:::|.|:
Human   113 ------QRLDLCKL-------GPNDNDTVRG---------------QIVVSLQSRDRI------- 142

  Fly   234 NGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPAL 298
                                                        |:|..|
Human   143 --------------------------------------------GTGGQV--------------- 148

  Fly   299 ARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDE 363
                                                                    :......|.
Human   149 --------------------------------------------------------VDCSRLFDN 157

  Fly   364 PLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHN-----TRKTTW 423
            .||.|||.|....||..|::|.||:|.||:||  .|..|....||....:||.|     |...|.
Human   158 DLPDGWEERRTASGRIQYLNHITRTTQWERPT--RPASEYSSPGRPLSCFVDENTPISGTNGATC 220

  Fly   424 QRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQ 488
            .:.:..||        ....|.||.::.|:.......|.               .||:|:|::..
Human   221 GQSSDPRL--------AERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRTT 262

  Fly   489 SDNRVYFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTFE 550
            ...:|||::.:...:.|.|||.. :::|.||   .||||||||||.||.|..:|||||.|.|.|.
Human   263 QQGQVYFLHTQTGVSTWHDPRVP-RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFT 326

  Fly   551 DPRPGA------------------------PKGAKGVYGVPRAYERSFRWKLSQFRY-LCQSNAL 590
            |||..|                        |...: ...||| |:|....||...|. |.|....
Human   327 DPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTE-CLTVPR-YKRDLVQKLKILRQELSQQQPQ 389

  Fly   591 PSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMY 655
            ..|.:|.|:|:.:||:||.|:|::...:|.:||.|.||||||||||||:|||.:|||||:|||.|
Human   390 AGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYY 454

  Fly   656 CLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTI 720
            .||:|:..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||:||||::|.|.:|:
Human   455 GLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITL 519

  Fly   721 KDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYIT 785
            .|:|.:||:.:|||:|:.:|:|... |:..|.|:....|:||.||||.||:...|.||||:||:.
Human   520 DDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVR 583

  Fly   786 LMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNR 850
            |...||..||||.|.....:|||||:|...||.|||:|||||:||:..:||.||:.||..:|...
Human   584 LYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTP 648

  Fly   851 NSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-WLPRS 914
            :|..|.|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.|.::...| .||::
Human   649 DSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKA 713

  Fly   915 HTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||||||:|:|||:||::|.|||..|||||.||..|
Human   714 HTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	26/127 (20%)
		WW	364..396	CDD:197736	16/31 (52%)
		WW	397..426	CDD:278809	9/33 (27%)
		WW	478..509	CDD:197736	9/30 (30%)
		WW	522..554	CDD:197736	22/31 (71%)
		HECTc	594..946	CDD:238033	187/352 (53%)
		HECTc	620..946	CDD:214523	177/326 (54%)
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028	34/173 (20%)
SMURF2	NP_073576.1	HUL4	<159..745	CDD:227354	271/614 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750