DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Su(dx) and HACE1

DIOPT Version :9

Sequence 1:NP_001259898.1 Gene:Su(dx) / 33379 FlyBaseID:FBgn0003557 Length:949 Species:Drosophila melanogaster
Sequence 2:NP_065822.2 Gene:HACE1 / 57531 HGNCID:21033 Length:909 Species:Homo sapiens


Alignment Length:347 Identity:149/347 - (42%)
Similarity:210/347 - (60%) Gaps:4/347 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly   596 ITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEY 660
            :.|.|.::|..|...:.:....:|::.:.:.|.||||:.. ||.||||.:||:|::||.|.||. 
Human   555 LLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFT- 617

  Fly   661 ANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725
            .:.:..:.|.|..||||||||.||:|.|:.:.:||.|.:.:...||..|||.:|...:..:|:.:
Human   618 QSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVAS 682

  Fly   726 IDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEW 790
            ||||:..:|.|:.||:|.:.||||.|||:.:|.|.:....||..|....||:.||.||:.|:||.
Human   683 IDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747

  Fly   791 RMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRH-YNRNSKQ 854
            ||||.|:.|...||:||:..:|...::.|||.||||:|.||.::||.||.:||.|.. |.|....
Human   748 RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPV 812

  Fly   855 VVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVG-KETWLPRSHTCF 918
            :.|||:.|.:...|:|..|||||||:.|||.||||.:||.:|.|.|.|..|. ....||.|.||.
Human   813 IQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCI 877

  Fly   919 NRLDLPPYKSYDQLVEKLTFAI 940
            |.|.||.|.|.:.|.::|..|:
Human   878 NMLKLPEYPSKEILKDRLLVAL 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(dx)NP_001259898.1 C2_E3_ubiquitin_ligase 48..173 CDD:175988
WW 364..396 CDD:197736
WW 397..426 CDD:278809
WW 478..509 CDD:197736
WW 522..554 CDD:197736
HECTc 594..946 CDD:238033 149/347 (43%)
HECTc 620..946 CDD:214523 144/323 (45%)
HACE1NP_065822.2 Ank_2 <27..>283 CDD:330894
ANK 1 64..93
ANK repeat 66..95 CDD:293786
ANK 92..217 CDD:238125
ANK repeat 97..128 CDD:293786
ANK 2 97..126
ANK repeat 130..161 CDD:293786
ANK 3 130..159
ANK repeat 163..194 CDD:293786
ANK 4 163..192
ANK 5 196..226
ANK repeat 196..221 CDD:293786
ANK 6 228..257
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..433
HECTc 554..903 CDD:238033 149/347 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.