DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(dx) and HECW2

DIOPT Version :9

Sequence 1:NP_001259898.1 Gene:Su(dx) / 33379 FlyBaseID:FBgn0003557 Length:949 Species:Drosophila melanogaster
Sequence 2:XP_006712709.1 Gene:HECW2 / 57520 HGNCID:29853 Length:1579 Species:Homo sapiens


Alignment Length:1460 Identity:355/1460 - (24%)
Similarity:526/1460 - (36%) Gaps:564/1460 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VNGAGSAS------PTPTSSSGA-GASGSANQGYHQ---LSVTIEE---ASLRNNGFLKPNPYVE 73
            ::||..|:      ..|....|| |..|.|:...|.   :|.|:.:   ..|:...|..|:||::
Human   146 ISGALRATTPCITVKNPAVMMGAEGMEGGASGNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLK 210

  Fly    74 LLIDSKSK------------RKTDLVKNSYLPKWNEE---FTVLITPNSTLHFKVLDHSSFRKD- 122
            :.|....|            |::.::.|:..|.|:.|   |..|:|  ..|..::.|  .|.|. 
Human   211 MSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLT--DVLEIEIKD--KFAKSR 271

  Fly   123 ----AMLGERIINLAHILQ--------------------HYNGRCEF-LELTIDL---FVTSKSD 159
                ..||:..|.:..:|:                    |.:|..:| :|:|..:   .:.|.||
Human   272 PIIKRFLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEEMLFSHSD 336

  Fly   160 NRQTKSGELVAI--LNG---------------------------------------------LKL 177
            ......|.::.:  :||                                             |::
Human   337 ASPEAVGTILGVNSVNGDLGSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEI 401

  Fly   178 DMSKL-----QIQPVAGQQNG-NPPVQAV--------NPSVVSDAAAGRSCMIYGGVRARMRLRS 228
            |..:|     :..|..|:|:. |..:.|:        ..:..|:.:.|.|..:........||.:
Human   402 DTEELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNA 466

  Fly   229 --------------------SSGNSNGG-----------------ETR----------------- 239
                                ||....||                 :|:                 
Human   467 MLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVENEEASTHEAA 531

  Fly   240 --------------SPLPNG-------------------------------------------GG 247
                          |.||.|                                           .|
Human   532 SFEDKPENLPELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASG 596

  Fly   248 DHRRSTQAPPVWEQQQQQSQ-----NQQQPLRMVNGSGAAVP----------------------- 284
            ..||:.......:|..:.||     ....|.|..:.|.|:..                       
Human   597 GSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLS 661

  Fly   285 ---------QTAPYPQQP--------------------PA--------PALARPLTQV------- 305
                     ::|.:|:.|                    ||        .|.:.|:.||       
Human   662 SVDTRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGEDEG 726

  Fly   306 ----YGALPENTQPAAVY-----LPAGGGAAVGPPGVAGPPIEQPGV--GLPV--------SQST 351
                ...:|:..:...|:     |.....||..||...|...|..|.  |...        ||:.
Human   727 PGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQAN 791

  Fly   352 DPQ-LQTQPA----------DDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPT---------- 395
            ..| |::.|:          .||.||..||.|:|.:||.:||||..|:|.|::||          
Human   792 GHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQR 856

  Fly   396 ----------------------------------------------------------------- 395
                                                                             
Human   857 SNSIQQMEQLNRRYQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRIT 921

  Fly   396 ----------------------------------------------------------------- 395
                                                                             
Human   922 LLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNM 986

  Fly   396 ------PLPPGWEIRKDGRGRVYYVDHNTRKTTW---------QRPNSERLMHFQHWQGQRAHVV 445
                  .||.|||::.|.:|:.::||||:|.||:         .||.| .|:|.||...||:|..
Human   987 FANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTS-ALVHRQHLTRQRSHSA 1050

  Fly   446 SQ--GNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKN--RTTQWE 506
            .:  .:.|:.......:|::....|::.....:.|:       ..:|..|.|:...|  ...|..
Human  1051 GEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPV-------AYNDKIVAFLRQPNIFEILQER 1108

  Fly   507 DP---------------RTQGQE--------------VSLINE---GPLPPGWEIRYTAAGERFF 539
            .|               ||:|..              :||..|   ..:||              
Human  1109 QPDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPP-------------- 1159

  Fly   540 VDHNTRRTTF-EDPR---PGAPKGAKGVY----GVPRAYERSFRWKLSQFRYLCQSNAL---PSH 593
              |.....:: :.||   ..:|:.:.|..    ..|..|:|.|..||..|....::...   |..
Human  1160 --HALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGK 1222

  Fly   594 IKITVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCL 657
            :|:.:.|..|.||:::|||.....:|:| :||:.|.|||||||.|.|||:|||:|.|:.||.|.|
Human  1223 LKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGL 1287

  Fly   658 FEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKD 722
            |||:..:.|::||:|.|....:|.::|:|.||.:.:||.|...:.:.||.||||.:|.....:.|
Human  1288 FEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSD 1352

  Fly   723 IETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLM 787
            :|.:|.||:.||.|:|||:|.:. |:|.|:|:.||.|||...|||..|....|||:||:|||..|
Human  1353 LEYLDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERM 1416

  Fly   788 TEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRN 851
            .:||:.||:.|||::.:.||.|||....:..||.|||||::.|..::|:.||:.||.|| .|:.|
Human  1417 VKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDN 1481

  Fly   852 SKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHT 916
            ...:.|||..|...:||:|.|||||||||..:|..|||.|.|||||:|||:||.||.|.|||:||
Human  1482 HIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHT 1546

  Fly   917 CFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            ||||||||||.|:..|.|||..|:|||..|
Human  1547 CFNRLDLPPYPSFSMLYEKLLTAVEETSTF 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(dx)NP_001259898.1 C2_E3_ubiquitin_ligase 48..173 CDD:175988 35/176 (20%)
WW 364..396 CDD:197736 17/177 (10%)
WW 397..426 CDD:278809 14/37 (38%)
WW 478..509 CDD:197736 7/47 (15%)
WW 522..554 CDD:197736 5/35 (14%)
HECTc 594..946 CDD:238033 177/353 (50%)
HECTc 620..946 CDD:214523 168/327 (51%)
HECW2XP_006712709.1 HECW_N 45..164 CDD:318711 4/17 (24%)
C2_NEDL1-like 185..321 CDD:176073 28/139 (20%)
NESP55 <471..638 CDD:115071 19/166 (11%)
PHA03169 591..>801 CDD:223003 34/209 (16%)
WW 816..845 CDD:306827 15/28 (54%)
WW 994..1023 CDD:306827 14/28 (50%)
HECTc 1223..1577 CDD:238033 178/355 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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