DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and SMURF1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_065162.1	Gene:	SMURF1 / 57154	HGNCID:	16807	Length:	757	Species:	Homo sapiens

Alignment Length:	928	Identity:	306/928 - (32%)
Similarity:	446/928 - (48%)	Gaps:	184/928 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNE 97
            |:.|...:||:.:  .:|:|...:...:.:.|..|:|:.::::|...: ..||.|||:..||||:
Human     2 SNPGTRRNGSSIK--IRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQ 64

  Fly    98 EFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQ 162
            .:.:.:....::...|.:|....|..  |...:....:|                   |.:.:|.
Human    65 HYDLYVGKTDSITISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAISRL 108

  Fly   163 TKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLR 227
            ..:|.       .:||:.||                  ||| .:||..|:   |...::.|.|:
Human   109 KDTGY-------QRLDLCKL------------------NPS-DTDAVRGQ---IVVSLQTRDRI- 143

  Fly   228 SSSGNSNGG---ETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPY 289
                 ..||   :.|..|.|.|..:..|....|:       |...::|....:.:|||
Human   144 -----GTGGSVVDCRGLLENEGTVYEDSGPGRPL-------SCFMEEPAPYTDSTGAA------- 189

  Fly   290 PQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQ 354
                                            ||||..        ..:|.|        |.|.:
Human   190 --------------------------------AGGGNC--------RFVESP--------SQDQR 206

  Fly   355 LQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTR 419
            ||.|             ||.....|..:.......:..:...||.|:|.|...:|:||::...|.
Human   207 LQAQ-------------RLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTG 258

  Fly   420 KTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWE 484
            .:||..|...          ..:..:..|:..:||....|..|:....:...:.|.|||||.|||
Human   259 VSTWHDPRIP----------SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWE 313

  Fly   485 KKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTF 549
            .:.....|:|||:|.|||||:.|||.                          ...::|..:....
Human   314 VRSTVSGRIYFVDHNNRTTQFTDPRL--------------------------HHIMNHQCQLKEP 352

  Fly   550 EDPRPGAPKGAKGVYGVP-RAYERSFRWKLSQFRY---LCQSNALPSHIKITVTRQTLFEDSYHQ 610
            ..|.|...:|:.....:| :.|||....||...|:   |.|..|  .|.:|.|:|:.:||:||.|
Human   353 SQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQA--GHCRIEVSREEIFEESYRQ 415

  Fly   611 IMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASY 675
            ||::...:|::||.:.||||||||||||:|||.:||.||:|||.|.||:|:..|.|.|||||.|.
Human   416 IMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS 480

  Fly   676 VNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDN 740
            :|||||.||.|:||.:.:|::||.:|..|||:||||::|.|.:.:.|:|::|||.:.||:|:.:|
Human   481 INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN 545

  Fly   741 NIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLE 805
            :|... |:..|.|:....|:|:.||||.||....||||||:||:.|...||..||||.|.....:
Human   546 DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQK 609

  Fly   806 GFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKR 870
            ||||::|...||.||::|||||:.|:..:|:.||:.||..:|...:|..|.||||.|...|.|:|
Human   610 GFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERR 674

  Fly   871 ARLLQFVTGTCRVPVGGFAELMGSN---GPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQ 931
            |||||||||:.|||:.||..|.||.   ||:.|.|..:...| .||::||||||:|:|||:||::
Human   675 ARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEK 739

  Fly   932 LVEKLTFAIEETEGFCQE 949
            |.|||..|:|||.||..|
Human   740 LYEKLLTAVEETCGFAVE 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	23/125 (18%)
		WW	364..396	CDD:197736	3/31 (10%)
		WW	397..426	CDD:278809	11/28 (39%)
		WW	478..509	CDD:197736	17/30 (57%)
		WW	522..554	CDD:197736	2/31 (6%)
		HECTc	594..946	CDD:238033	182/355 (51%)
		HECTc	620..946	CDD:214523	171/329 (52%)
SMURF1	NP_065162.1	C2_Smurf-like	14..138	CDD:176028	34/175 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..237		11/72 (15%)
		WW	236..267	CDD:197736	12/30 (40%)
		WW	307..339	CDD:197736	18/31 (58%)
		HECTc	399..754	CDD:238033	182/355 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750