DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and wwtr1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001032785.1	Gene:	wwtr1 / 568008	ZFINID:	ZDB-GENE-051101-1	Length:	391	Species:	Danio rerio

Alignment Length:	263	Identity:	67/263 - (25%)
Similarity:	107/263 - (40%)	Gaps:	59/263 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 VPQTAPYPQQPPAPALARPLTQVYGALP------ENTQPAAVYLPAGGGAAVGPPGVAGPPIEQP 341
            :||:  :.|:|.:.:.:|..:...|:||      ..:.||::.||||        .|:||   .|
Zfish    45 MPQS--FFQEPDSGSHSRQSSADSGSLPPRVHFRSRSSPASLQLPAG--------SVSGP---SP 96

  Fly   342 GVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKD 406
            |   .:...|..| ....|::.|||.|||:.....|::|:::|..:.|.|..|         ||.
Zfish    97 G---RLHSHTRHQ-SCDVAEELPLPPGWEMAFTPNGQKYFLNHIEKITTWHDP---------RKS 148

  Fly   407 GRGRVYYVD-HN---------TRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQP 461
            ....|..:. ||         .|.....:||..        ..|:||   |..|::|..||||.|
Zfish   149 MTPSVAQLSLHNQVSNTASIQQRSMALSQPNLV--------LNQQAH---QQQQQHLQQQQQQVP 202

  Fly   462 TAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSL----INEGP 522
            ..|..|..|  :.:..|:.:...::.|...|:..:..:....|........|||:|    ::...
Zfish   203 VQVPVQAPQ--QQSSQPMMNLSAQQHQQKMRLQRIQMERERIQRRQEELMRQEVALRQLPMDSDN 265

  Fly   523 LPP 525
            |||
Zfish   266 LPP 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	12/31 (39%)
		WW	397..426	CDD:278809	6/38 (16%)
		WW	478..509	CDD:197736	4/30 (13%)
		WW	522..554	CDD:197736	3/4 (75%)
		HECTc	594..946	CDD:238033
		HECTc	620..946	CDD:214523
wwtr1	NP_001032785.1	WW	115..146	CDD:197736	12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810