DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and wwp2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_005163228.1	Gene:	wwp2 / 564527	ZFINID:	ZDB-GENE-000607-82	Length:	867	Species:	Danio rerio

Alignment Length:	943	Identity:	494/943 - (52%)
Similarity:	623/943 - (66%)	Gaps:	106/943 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SGAGASGSAN-QGYHQLSVTIEEASLRNNGFLKPN------PYVELLID--SKSKRKTDLVKNSY 91
            :.|..|.||: |...:..:|::..|.:......||      .:||:..|  |...:||.......
Zfish     2 AAASVSQSASIQAIEKSQLTLKVLSAKPQSPKLPNRHSRLSSFVEVTADGLSSETKKTGKRSGHL 66

  Fly    92 LPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTS 156
            ..:|||:.|:.:||.|.|..||....:.||: :||...|:|...|:.::|:.|.::|::.|...:
Zfish    67 ELQWNEDLTLNVTPQSRLDLKVWSCHTLRKE-LLGSATIDLLDTLRTHDGKMENVQLSLVLQTEN 130

  Fly   157 KSDNRQTKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVR 221
            |..  ....|||...|:||.:|:..|        .||:.....::.|
Zfish   131 KGS--VVAGGELNVCLDGLVVDLGSL--------PNGSAASDKIHSS------------------ 167

  Fly   222 ARMRLRSSSGNSNGGETRS-PLPNG---GGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNG--SG 280
                 |||...::..||.| ..|.|   |...|.|....|.          :.|...:.||  :|
Zfish   168 -----RSSLHRAHSEETPSTSSPRGRSLGQSSRGSCGDSPA----------EIQGAALTNGDVNG 217

  Fly   281 AAVPQTAPYPQQPPAPAL---------ARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGP 336
            |....|:.:..:.....|         |..|...:...|..:.|:....|        |.|...|
Zfish   218 ALAETTSRHNSKTTVNNLSSAGKGETAANGLESAHLTCPAPSSPSLSSNP--------PDGTVPP 274

  Fly   337 PIEQPGVGLPVS-QSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPG 400
            |..:|    |.| :.:|....||..|  .||||||.|:..:||.|||||||::|.||:  |||||
Zfish   275 PAAEP----PASTEQSDTTSDTQNTD--ALPAGWEQRILPHGRVYYVDHNTKTTTWER--PLPPG 331

  Fly   401 WEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPT 462
            ||.|.|.|||.||||||||.||||||.:|.:.:::.||.||:.:   :.|.||||||     ||:
Zfish   332 WEKRVDQRGRFYYVDHNTRTTTWQRPTAESVRNYEQWQSQRSQLQGAMQQFNQRYLY-----QPS 391

  Fly   463 AVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGW 527
            ....     :.|.||.||.||||: |.:.|||:|||..||||||||||||    :|.|.||||||
Zfish   392 GAVV-----ENDPLGALPPGWEKR-QDNGRVYYVNHNTRTTQWEDPRTQG----MIQEPPLPPGW 446

  Fly   528 EIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAK-GVYGVPRAYERSFRWKLSQFRYLCQSNALP 591
            |::|||.|.|:|||||:|.|||:|||||...|:: |  |.|.||:||||||..|||:||.|||||
Zfish   447 EMKYTAEGVRYFVDHNSRTTTFKDPRPGFESGSRQG--GSPGAYDRSFRWKYHQFRFLCHSNALP 509

  Fly   592 SHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYC 656
            ||:||:|:||||||||:.|||.:..|:||||||||.||||||||||::|||||||||||||||||
Zfish   510 SHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYC 574

  Fly   657 LFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIK 721
            |||||.||||.|||||||.:|||||.||:|||||||||||||:||.:|||:||||||||||.|:|
Zfish   575 LFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKKPTLK 639

  Fly   722 DIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITL 786
            |:|:||||||||::|||:|:::|||:||:|:.|.|:||::..|:||::||.|.||::||||||.|
Zfish   640 DLESIDPEFYNSIMWVKENDLEECGVELYFAQDMEILGKVTTHQLKDDGENELVTQDNKEEYIGL 704

  Fly   787 MTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRN 851
            :|:||.|||:|:|||.||:|||||||||||:||||:||||:|||||::|:.|||:|||||||.:|
Zfish   705 LTDWRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLNDWQKNTIYRHYTKN 769

  Fly   852 SKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHT 916
            |||:.||||.|:|.|||||.|||||||||||:||||||||:||||||:|||:|||||||||||||
Zfish   770 SKQIHWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHT 834

  Fly   917 CFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |||||||||||:.:||.|||.|||||||||.||
Zfish   835 CFNRLDLPPYKNLEQLREKLLFAIEETEGFGQE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	35/132 (27%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	23/28 (82%)
		WW	478..509	CDD:197736	20/30 (67%)
		WW	522..554	CDD:197736	23/31 (74%)
		HECTc	594..946	CDD:238033	268/351 (76%)
		HECTc	620..946	CDD:214523	252/325 (78%)
wwp2	XP_005163228.1	C2_E3_ubiquitin_ligase	17..145	CDD:175988	35/130 (27%)
		WW	298..327	CDD:197736	19/30 (63%)
		WW	328..357	CDD:278809	23/28 (82%)
		WW	403..431	CDD:278809	19/28 (68%)
		WW	441..473	CDD:197736	23/31 (74%)
		HECTc	513..865	CDD:238033	269/351 (77%)
		HECTc	536..864	CDD:214523	253/327 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595826
Domainoid	1	1.000	525	1.000	Domainoid score	I277
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	940	1.000	Inparanoid score	I335
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm25253
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840