DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and smurf2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	959	Identity:	317/959 - (33%)
Similarity:	450/959 - (46%)	Gaps:	248/959 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ANQGYH-------QLSVTIEEASLRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFT 100
            :|||..       :|:|...:..::.:.|..|:|:.::::|...: ..||.|:|:..||||:.:.
Zfish     2 SNQGVRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVRNTLDPKWNQHYD 66

  Fly   101 VLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKS 165
            :.|..:.::...|.:|....|..  |...:....:|                   |.|.||...:
Zfish    67 LYIGKSDSITISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNSINRLKDT 110

  Fly   166 GELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSS 230
            |.       .:||::||      |..:             ||...|:   |...:::|.|:
Zfish   111 GY-------QRLDLNKL------GPND-------------SDTVRGQ---IVVSLQSRDRI---- 142

  Fly   231 GNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPA 295
                                                           |||
Zfish   143 -----------------------------------------------GSG--------------- 145

  Fly   296 PALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPA 360
                                                   ||.::                 ....
Zfish   146 ---------------------------------------GPVVD-----------------CSRL 154

  Fly   361 DDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQR 425
            .|..||.|||.|....||..|::|.||||.||:||  .|..|....||.....||.||...|
Zfish   155 FDNDLPDGWEERRTASGRIQYLNHITRSTQWERPT--RPASEYSSPGRPLSCLVDENTPIMT--- 214

  Fly   426 PNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSD 490
            ||....:.....:.|...|.||.::.|:.......|.               .||:|:|::....
Zfish   215 PNGAAGVPADDPRVQERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRTTQQ 264

  Fly   491 NRVYFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDP 552
            .:|||::.:...:.|.|||.. :::|.:|   .||||||||||.||.|..:|||||.|.|.|.||
Zfish   265 GQVYFLHTQTGVSTWHDPRVP-RDLSNVNCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDP 328

  Fly   553 RPGA---------PKGAKGV-------------------------------YGVPRAYERSFRWK 577
            |..|         |.|::..                               ..||: |:|....|
Zfish   329 RLSANLHLVLNPSPNGSRAAVEAQSSSRPGQLKEQAQSVVSPGNLPEDPECLTVPK-YKRDLVQK 392

  Fly   578 LSQFRY-LCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSRE 641
            |...|. |.|......|.:|.|:|:.:||:||.|:|::...:|.:||.:.||||||||||||:||
Zfish   393 LKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMVKFRGEEGLDYGGVARE 457

  Fly   642 WFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFT 706
            |.:|||||:|||.|.||:|:..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||
Zfish   458 WLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFT 522

  Fly   707 MPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGE 771
            :||||::|.|.:|:.|:|::||:.:|||:|:.||:|... |:..|.|:....|:||.||||.||:
Zfish   523 LPFYKQLLGKPITLDDMESVDPDLHNSLVWILDNDITGV-LDHTFCVEHNAYGEIIQHELKPNGK 586

  Fly   772 KERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDV 836
            ...||::.|:||:.|...||..||||.|.....:|||||:|...||.|||:|||||:||:..:|:
Zfish   587 SIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDI 651

  Fly   837 EDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFC 901
            .||:.||..:|...:|..|.|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.
Zfish   652 NDWKSNTRLKHCTPDSNIVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFT 716

  Fly   902 IEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            |.::...| .||::||||||:|:|||:|||:|.:||..|||||.||..|
Zfish   717 IHQIDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAVE 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	25/132 (19%)
		WW	364..396	CDD:197736	17/31 (55%)
		WW	397..426	CDD:278809	9/28 (32%)
		WW	478..509	CDD:197736	9/30 (30%)
		WW	522..554	CDD:197736	22/31 (71%)
		HECTc	594..946	CDD:238033	184/352 (52%)
		HECTc	620..946	CDD:214523	174/326 (53%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028	34/173 (20%)
		WW	159..188	CDD:278809	16/28 (57%)
		WW	252..283	CDD:197736	9/30 (30%)
		WW	298..330	CDD:197736	22/31 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375		2/33 (6%)
		HECTc	410..762	CDD:238033	184/352 (52%)
		HECTc	437..762	CDD:214523	174/325 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167687at2759
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750