DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and hectd2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_009304826.1	Gene:	hectd2 / 562999	ZFINID:	ZDB-GENE-100405-3	Length:	756	Species:	Danio rerio

Alignment Length:	370	Identity:	121/370 - (32%)
Similarity:	188/370 - (50%)	Gaps:	30/370 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 IKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLF 658
            :.|.|.|..|..||..::.|..| :|:::|.:.|.||.|||.||:::|||.||..::.:..|.:|
Zfish   397 LNIKVRRLQLVSDSLDELSRKRA-DLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHTDYGMF 460

  Fly   659 EYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLN-------- 715
            .|..::    |....|....|:...|:.:|..:.:|:|:...:...|....||::|.
Zfish   461 TYVKES----QCYWFSSWKCDNYSEFRLVGALMGLAVYNSITLDIRFPPCVYKKLLTPPIVPCDL 521

  Fly   716 ------KKLTIKDIETIDPEFYNSL--IWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEK 772
                  ..||:.|::.|.|:..:.|  :...:.|::| .....|.|..|.||.:..:.||..|:|
Zfish   522 DTPVGMATLTLDDLQQIMPDLAHGLGELLSYEGNVEE-DFYTTFQVFQEELGVVKAYNLKPGGDK 585

  Fly   773 ERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVE 837
            ..||..|::||:.|..::.:.:.|.:|...|..||:.|.....|......|:|:::||..::|:.
Zfish   586 IPVTNLNRKEYVQLYIDFLLNKSIYRQFAAFYHGFHSVCASNALMLLRPEEVEILVCGSPNLDMG 650

  Fly   838 DWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCI 902
            ..||...|..|::....:..||..|.....|.:.:||.|.||:.||||||.|:|       .|.|
Zfish   651 SLQRVVQYEGYSKTDPTIRAFWDVVLAFPLELQKKLLHFTTGSDRVPVGGMADL-------NFKI 708

  Fly   903 EKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            .|:...| |||.||||||::.||||||..:|.:|||.||...|||
Zfish   709 SKIDVSTDWLPVSHTCFNQICLPPYKSKKELRQKLTIAISNAEGF 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033	119/368 (32%)
		HECTc	620..946	CDD:214523	110/342 (32%)
hectd2	XP_009304826.1	HECTc	397..754	CDD:238033	121/370 (33%)
hectd2	XP_009304826.1	HECTc	420..753	CDD:214523	111/344 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900