Protein Alignment Su(dx) and nedd4l

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_021324693.1
• Gene: nedd4l / 559634
• ZFINID: ZDB-GENE-051118-2
• Length: 1274
• Species: Danio rerio
• Alignment Length: 1300
• Identity: 377/1300 - (28%)
• Similarity: 531/1300 - (40%)
• Gaps: 429/1300 - (33%)

  Fly    37 GAGASGSANQGYHQLSVTIEE---------------ASLRNNGFLK-PNPYVELLIDSKSKRKTD 85
            |:|.|.:|.: ..:|:.|:||               |..||.|..: |.|...:..|:..||.:.
Zfish    10 GSGRSNTAPE-LEELNGTVEEEGDISYNSTGAMVVHAQPRNGGHAESPEPGTVVGSDASLKRSSS 73

  Fly    86 LVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAM------------------LGERIINL 132
            :    ::|:...:.....|.::::...:...::..:||:                  .||. :.|
Zfish    74 M----FIPQLQGQAESRTTKSTSVQISLQRTTAPHEDALPFDPPPAYPQDPAPPYTEPGES-LPL 133

  Fly   133 AHILQHYNGRCEFLELT-------IDLFVTSKSD--NRQTKSGELVAILNGLKL--------DMS 180
            .....:|.. |:.:|.|       ..:|.....|  |..|........:.|:.:        |:.
Zfish   134 PPPPTYYKS-CQNVEQTQKDTEPKRQVFCVRPCDGQNGYTHGNPQGITIGGVCIRRRSADGSDVQ 197

  Fly   181 KLQIQPVA--GQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSG----------NS 233
            :.:|.|.:  |....|..||.     .||...|...:|:...:.:.|..||:.          .|
Zfish   198 QFRIMPYSEDGHNGHNWSVQQ-----CSDRGPGAQRLIFQLQKDQGRQPSSTSQPDVSDLGITGS 257

  Fly   234 NGG------------ETRSPLPNGGGDHRRSTQA---PPVWEQQQQ----------------QSQ 267
            .|.            .|..||...|...|..:..   .|:.|.:.:                :.|
Zfish   258 KGSRLVRYPRIRLERSTSQPLQPRGAPSRLGSMPNLHAPISEMETESDFIENGAQGCTFKIRKEQ 322

  Fly   268 NQQQPLRMV----NGSGAAVPQ------TAPYPQQPPA--------------------------- 295
            |.|||...:    .|..:.:.:      .||....|.|
Zfish   323 NSQQPKFKIYFSQGGEHSPILERNISIGKAPTCSNPQAHIGLDRPKNGHFNNGQTRDDFLGQVDV 387

  Fly   296 ---------PALARPLT-------------QVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPI 338
                     ||:.||.|             :|.|.|    :....|||..||..
Zfish   388 PLTHLPTEDPAMERPYTFKDFLLRPRSHKSRVKGYL----RLKMAYLPKNGGHE----------- 437

  Fly   339 EQPG------VGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKP--- 394
            |:.|      .|..|:.||||..|.......|||.|||.::|..||.|||:||.|:|.|::|
Zfish   438 EESGEMREEAEGWEVTDSTDPGSQRPQQLLPPLPPGWEEKVDNLGRTYYVNHNNRTTQWKRPSSV 502

  Fly   395 ----------------------------------------------------------------- 394
                                                                             
Zfish   503 DVVSETENDNQLRQINQEAHRVFRSRRHISEDLENEQLDIRDIDDSWEPISEEDPTLLTDGLNHS 567

  Fly   395 ----------------------------------------------------------------- 394
                                                                             
Zfish   568 LSGPSSLAMPLSSTPDFSDEISLRLSLAPDTNGEIPGPSSAVQSHLSSRLRSSSMTDGVSDQAQP 632

  Fly   395 ---------------------------------TP-LPPGWEIRKDGRGRVYYVDHNTRKTTWQR 425
                                             || ||||||.|||.:||.|||:||.|.|||.|
Zfish   633 PTPTQSSQTRRTRAQTVTGVEDTMSPSASYALTTPGLPPGWEERKDPKGRTYYVNHNNRSTTWTR 697

  Fly   426 PNSERLMHFQHWQ-GQRAHVVSQG-------------------------NQRYLYS--------- 455
            |..:     ||.: |....|.:.|                         ..|.|.|
Zfish   698 PILQ-----QHTEDGASTSVAAVGGATAATPPASTPSTSSGHLSEPQVRRPRSLSSPTVTLSSPL 757

  Fly   456 ------------------QQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRT 502
                              .|..||:..::..||...:. ..||.|||.:|..:.|.:|::|.:||
Zfish   758 EGANNVPIRRAVKDTFSNPQSPQPSPYSSPKTQHKANQ-SFLPPGWEMRIAPNGRPFFIDHNSRT 821

  Fly   503 TQWEDPRTQ-----GQEVSLI--NEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGA 560
            |.|||||.:     ..:.||.  :.||||||||.|..|.|..|::|||.::|.:||||..:|
Zfish   822 TTWEDPRLKYPVHMRTKASLDPGDLGPLPPGWEERVHADGRTFYIDHNNKKTQWEDPRLQSP--- 883

  Fly   561 KGVYGVPRAYERSFRWKLSQFRYLCQSNA-LPSHIKITVTRQTLFEDSYHQIMRLPAYE-LRRRL 623
             .:.|....|.|.|:.|...||...:..| :|:..::.:.|..:||:||.:||.|...: |:.||
Zfish   884 -AITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSLKRPDSLKARL 947

  Fly   624 YIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFI 687
            :|.|..|:|||||||:||||||||.|:.||.|.||||:..:||:|||||.| ..|.|||.|||||
Zfish   948 WIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFI 1012

  Fly   688 GRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFS 752
            ||...||:|||:.:...|..||||.||.|::|:.|:|::|.|:||||.|:.:|  |...|:|.|.
Zfish  1013 GRVAGMAVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN--DPTELDLRFC 1075

  Fly   753 VDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLK 817
            :|.:..||....:||.:|....||.:||:|||.|:.:||....:::|...|||||.|::|::.:|
Zfish  1076 IDEDNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIK 1140

  Fly   818 YFDERELELILCGMQDVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTC 881
            .|||.||||::||:.||||.||:::|:|:: |..|...:.|||:.|...|.|||.|||||||||.
Zfish  1141 IFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTS 1205

  Fly   882 RVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||:.|||||.||||||.|.||:.|....|||:||||||||||.|::::.|.|||..|:|..:||
Zfish  1206 RVPMNGFAELYGSNGPQLFTIEQWGTPDKLPRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGF 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	28/167 (17%)
		WW	364..396	CDD:197736	18/197 (9%)
		HUL4	<395..946	CDD:227354	269/615 (44%)
nedd4l	XP_021324693.1	C2	<374..430	CDD:472691	8/59 (14%)
		WW	473..499	CDD:459800	14/25 (56%)
		WW	669..698	CDD:459800	20/28 (71%)
		WW	798..829	CDD:197736	16/30 (53%)
		WW	848..880	CDD:197736	18/31 (58%)
		HECTc	941..1270	CDD:214523	175/330 (53%)