DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and ube3b

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001108154.1	Gene:	ube3b / 556864	ZFINID:	ZDB-GENE-060526-231	Length:	1069	Species:	Danio rerio

Alignment Length:	502	Identity:	145/502 - (28%)
Similarity:	233/502 - (46%)	Gaps:	72/502 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 WED--PRTQGQEVSLINEGPLPPGW-EIRYTAAGERFFV--DHNTRR-----TTFEDPRPGAPKG 559
            |:.  ...:|:::.|.:.   ..|| .:.|.....|.|.  ||..|:     ..|::...|..:.
Zfish   577 WDGILENAKGEKLDLFHS---VHGWLMVLYERDCRRRFTPEDHWLRKDLKPSLLFQELEKGKKRA 638

  Fly   560 AKGVYGVPRAYERSFRWKLSQFRYLC-----------QSNALPSHIKITVTRQTLFEDSYHQIMR 613
            ...:..:|.......|..|  ||.:.           .|:|.|....||:.|..:.||.|.|:.|
Zfish   639 QLLLQYIPHVIPHKNRVLL--FRNIVTKEKETLGLVETSSASPHVTHITIRRSRMLEDGYDQLRR 701

  Fly   614 LPAYELRRRLYIIFRG-----EEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPA 673
            ||...::..:.:.|..     |.|:|..||.:|:...:..:|.||...||: ....|..|..:|.
Zfish   702 LPVNSIKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKKVFNPALNLFK-TTSGNERLYPSPT 765

  Fly   674 SYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKL---------TIKDIETIDPE 729
            |.::.:|||.|:|:|:.:..|:|.|..:    .:||....|::.|         :|.::.::|.|
Zfish   766 SSIHENHLQLFEFVGKMLGKAMYEGIVV----DVPFASFFLSQVLGHHHSTFYSSIDELPSLDSE 826

  Fly   730 FYNSLIWVK--DNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRM 792
            ||.:|..:|  |.::.:.||.|  |.|.||:||::.|||...|:...||.|||..||.||..:||
Zfish   827 FYKNLTSIKRYDGDVSDLGLTL--SYDEEVMGQLVCHELIPGGKTMPVTNENKISYIHLMAHFRM 889

  Fly   793 TRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCG-MQDVDVEDWQRNTI-YRHYNRNSKQV 855
            ...|::||..|:.||..::..|||..|...|::.::.| ..::|::|.:::|: |..::.:.:.:
Zfish   890 HTQIKEQTAAFIRGFRSIINPEWLHMFSTPEVQRLISGDNAEIDLDDLKKHTVYYGGFHSSHRVI 954

  Fly   856 VWFWQFV-RETDNEKRARLLQFVTGTCRVPVGGFAEL--------------------MGSNGPQR 899
            :|.|..: .:...::||..|:|||...|.|:.|||.|                    :||.....
Zfish   955 LWLWDILSSDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGF 1019

  Fly   900 FCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |.|.|......||.|.||||.|.||.|.....|.:||.:||....||
Zfish  1020 FTIRKKEPGGRLPTSSTCFNLLKLPNYSKKSILRDKLRYAISMNTGF 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	1/5 (20%)
		WW	522..554	CDD:197736	9/39 (23%)
		HECTc	594..946	CDD:238033	122/390 (31%)
		HECTc	620..946	CDD:214523	112/364 (31%)
ube3b	NP_001108154.1	IQ	28..50	CDD:197470
		HECTc	683..1067	CDD:238033	124/391 (32%)
		HECTc	708..1066	CDD:214523	112/364 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810