DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Magix

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_061302.2	Gene:	Magix / 54634	MGIID:	1859644	Length:	324	Species:	Mus musculus

Alignment Length:	348	Identity:	67/348 - (19%)
Similarity:	107/348 - (30%)	Gaps:	129/348 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 MSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGE-----T 238
            :.:|..:|:|.:                 |||..:.:: ....|.:|||.:.|.|....     |
Mouse    32 LERLDARPLAAR-----------------AAADLTALV-RKAGATLRLRHTEGVSGLDSADIEVT 78

  Fly   239 RSPLPNG-----GGDHRRSTQAPPVWEQQQQQSQNQ-QQPLRMVNGSGA-AVPQTAPYPQQPPAP 296
            .|.||:.     ...|:|| :....|.:....:||: ...|::...:|. :|..|    :.|...
Mouse    79 DSRLPHATLVKHRPQHQRS-ETLGTWTEPLPVTQNKASYALKVPQATGRFSVELT----RGPAGF 138

  Fly   297 ALA----------RPLTQVYGALPENTQPAAVYLPAG-------GGAAVG--------------- 329
            .|.          .||| |:|.|.:........|.||       |.:..|
Mouse   139 GLTLSGGRNVSGDAPLT-VHGLLKDGPAQRCGRLQAGDLVLYINGQSTQGLTHAQVVERIRTGGP 202

  Fly   330 --------PPGVAGPPIEQPGVGLPVSQSTD------------------PQLQTQP-ADDEPLPA 367
                    |..:.|..|::.|......:|.|                  |:.:|.| ...|.:..
Mouse   203 HLCLVLQRPQDMDGSRIKEVGGHRKTDRSLDPRGSRVESRSTISPVHHRPKTRTSPRPSPEAVAI 267

  Fly   368 GWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLM 432
            |..:|.        |:|.|...  |...|..||                     .|..|:.:||.
Mouse   268 GHVVRA--------VEHPTEDL--ENRIPGTPG---------------------PWLVPSEDRLS 301

  Fly   433 HFQHWQG---QRAHVVSQGNQRY 452
            .....:|   |.|..::.|.:|:
Mouse   302 RALGVRGGGAQLALEMAAGRRRH 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	6/31 (19%)
		WW	397..426	CDD:278809	3/28 (11%)
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033
		HECTc	620..946	CDD:214523
Magix	NP_061302.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PDZ	126..211	CDD:214570	15/89 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..263		8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900