DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	388	Identity:	87/388 - (22%)
Similarity:	141/388 - (36%)	Gaps:	96/388 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 LPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEV---SLINEGPLPPGWEIRYTAAGERFFV 540
            ||..|...|....||:|:|.:.::|.|..|.| |:.|   .......||.|||..||..|.|:::
Human    12 LPRSWTYGITRGGRVFFINEEAKSTTWLHPVT-GEAVVTGHRRQSTDLPTGWEEAYTFEGARYYI 75

  Fly   541 DHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKIT-------- 597
            :||.|:.|.:.|..|.|.....::.|......:...:..:.|.:...|. .|:..:|
Human    76 NHNERKVTCKHPVTGQPSQDNCIFVVNEQTVATMTSEEKKERPISMINE-ASNYNVTSDYAVHPM 139

  Fly   598 --VTRQTLFEDSYH-------QIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNP 653
              |.|.:......|       .|.|.|...:.||.::..:...|:...  .:.||      ||:.
Human   140 SPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLW--KKRWF------VLSD 196

  Fly   654 MYCLFEYANKNNY---------SLQINPASYVNPDHLQYFKFIGRFIAMALYHG--RFIY----S 703
            : |||.|.::...         |.||  |...:.||      |.|..|....|.  |..|    :
Human   197 L-CLFYYRDEKEEGILGSILLPSFQI--ALLTSEDH------INRKYAFKAAHPNMRTYYFCTDT 252

  Fly   704 GFTMPFY-KRMLN------------------KKLTIKDIET------------IDPEFYNSLIWV 737
            |..|..: |.||:                  .|:|.::..|            |.||..|:
Human   253 GKEMELWMKAMLDAALVQTEPVKRITFNFRVDKITSENAPTKETNNIPNHRVLIKPEIQNN---- 313

  Fly   738 KDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQT 800
             ..|.:...:|...:::.|..|      .:::|:...:|:.|..:..:|.:|:........||
Human   314 -QKNKEMSKIEEKKALEAEKYG------FQKDGQDRPLTKINSVKLNSLPSEYESGSACPAQT 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	10/29 (34%)
		WW	522..554	CDD:197736	14/31 (45%)
		HECTc	594..946	CDD:238033	53/270 (20%)
		HECTc	620..946	CDD:214523	46/227 (20%)
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809	10/28 (36%)
		WW	58..87	CDD:278809	13/28 (46%)
		PH_PEPP1_2_3	164..267	CDD:270068	30/119 (25%)
		PH	170..266	CDD:278594	28/112 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900