DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and UBR5

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	809	Identity:	172/809 - (21%)
Similarity:	274/809 - (33%)	Gaps:	250/809 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 QQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPA--------- 316
            |.:|:.:.::||:                                   |||.|:.:
Human  2115 QNRQKKEGEEQPV-----------------------------------LPEETESSKPGPSAHDL 2144

  Fly   317 AVYLPAGGGAAVGPPGVAGPPIE--QPG---VGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQY 376
            |..|.:...|.:|.....|||:.  :|.   :|:.:|.             :.|...|.:.|:.:
Human  2145 AAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISH-------------DMLLGRWRLSLELF 2196

  Fly   377 GRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQR 441
            ||.:..|....           ||..:.:.|...|        |.:..|...|:|.:    |..|
Human  2197 GRVFMEDVGAE-----------PGSILTELGGFEV--------KESKFRREMEKLRN----QQSR 2238

  Fly   442 AHVVSQGNQRYLYSQQQQQ-------------PTAV-TAQVTQDDEDALGPLPDGWEKKIQSD-N 491
            ...:.....|.|..||..:             |.|| ..:||..||...|   .|..:...:. .
Human  2239 DLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEG---SGVARSFYTAIA 2300

  Fly   492 RVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGA 556
            :.:..|.|....:......:|...||:.          |....|||   |....|........|.
Human  2301 QAFLSNEKLPNLECIQNANKGTHTSLMQ----------RLRNRGER---DREREREREMRRSSGL 2352

  Fly   557 PKGAKGVYGVPRAYERSFRWKLS----QFRYLCQSN------ALPSHIKITVTRQTLFEDSYHQI 611
            ..|::      |..:|.||.:||    .||...:.|      .||:|      ||.|.|..|.::
Human  2353 RAGSR------RDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAH------RQALGERLYPRV 2405

  Fly   612 MRL-PAY------------------------ELRRRL-----YIIFRGEEG-----LDYG----- 636
            ..: ||:                        .||.|:     .||..|.|.     ||.|
Human  2406 QAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSS 2470

  Fly   637 -----------GVSREWFFLLSHEVLN-------------PMYCLFEYANKNNYSLQINPASYVN 677
                       |.||        .|::             |::  ::...:..|:    |....|
Human  2471 EKVQQENRKRHGSSR--------SVVDMDLDDTDDGDDNAPLF--YQPGKRGFYT----PRPGKN 2521

  Fly   678 PD-HLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSL----IWV 737
            .: .|..|:.|||.:.:.|...............|.:|.:|:...|....||..|.||    :..
Human  2522 TEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILAS 2586

  Fly   738 KDNNIDE--CGLELWFSVDF---EVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIE 797
            :.::.|.  ..::|.|::|.   |..||:   ||..||....||.:|..||:....|.||....|
Human  2587 QSSDADAVFSAMDLAFAIDLCKEEGGGQV---ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAE 2648

  Fly   798 QQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYN----RNSKQVV-- 856
            |......:|..:|:|...|:.....:..|::.|..:|:|   |....:..:|    .|:::::
Human  2649 QPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNV---QMLISFTSFNDESGENAEKLLQF 2710

  Fly   857 --WFWQFVRETDNEKRARLLQFVTGTCRVPVG--GFAELMGSNGPQRFCIEKVGKETWLPRSHTC 917
              |||..|.:....:|..|:.|.|.:..:|..  ||.       |......:...:..||.::||
Human  2711 KRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQ-------PMPSITIRPPDDQHLPTANTC 2768

  Fly   918 FNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            .:||.:|.|.|...|.:||..|| :|:.|
Human  2769 ISRLYVPLYSSKQILKQKLLLAI-KTKNF 2796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	6/31 (19%)
		WW	397..426	CDD:278809	5/28 (18%)
		WW	478..509	CDD:197736	3/31 (10%)
		WW	522..554	CDD:197736	6/31 (19%)
		HECTc	594..946	CDD:238033	99/435 (23%)
		HECTc	620..946	CDD:214523	91/384 (24%)
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		7/59 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		20/87 (23%)
		PolyA	2389..2452	CDD:197769	15/68 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		4/27 (15%)
		HECTc	2501..2796	CDD:214523	78/314 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900