DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and ASCC1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001185728.1	Gene:	ASCC1 / 51008	HGNCID:	24268	Length:	400	Species:	Homo sapiens

Alignment Length:	135	Identity:	31/135 - (22%)
Similarity:	51/135 - (37%)	Gaps:	38/135 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 IDSKSKRKTDLVKNSYLPKWNEE----------------FTVLITPNSTLHFKVLDHSSFRKDAM 124
            ||.::.||..:.:.:|..:.:||                :.|..||           ..||....
Human    11 IDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTP-----------QGFRSTLR 64

  Fly   125 LGERIINLAHILQHYNGRCEFLELTIDL--FVTSKSDNRQTKSGELVAILNGLKLDM-SKLQIQ- 185
            ....:.||.|:  :.:..|.|.::|:|.  ..|.||.:...|.|:     ...|::| :|..|.
Human    65 APSLLYNLIHL--NTSNDCGFQKITLDCQNIYTWKSRHIVGKRGD-----TRKKIEMETKTSISI 122

  Fly   186 PVAGQ 190
            |..||
Human   123 PKPGQ 127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	24/114 (21%)
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033
		HECTc	620..946	CDD:214523
ASCC1	NP_001185728.1	Required for interaction with ASCC3. /evidence=ECO:0000269\|PubMed:29997253	1..53		7/41 (17%)
		vigilin_like_KH	99..148	CDD:239087	9/34 (26%)
		PLN00108	157..370	CDD:177724
		AKAP7_NLS	161..349	CDD:287446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900