Protein Alignment Su(dx) and Huwe1

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: XP_063136267.1
• Gene: Huwe1 / 501546
• RGDID: 1561763
• Length: 4460
• Species: Rattus norvegicus
• Alignment Length: 1004
• Identity: 269/1004 - (26%)
• Similarity: 414/1004 - (41%)
• Gaps: 243/1004 - (24%)

  Fly     4 GNGLPAGAASGG--------MEAGQTVNGAGSASPTPTSSS----------------GAGASGSA 44
            ||..||....||        :.:|.|.|....:....||.|                ..|.||:.
  Rat  3636 GNKSPAKVGEGGSSSVDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTR 3700

  Fly    45 N-------QGYHQLSVTIEE------ASLRNNGFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWN 96
            :       .|...|..|:.:      |.||           |..::.:.:.:.:.:....||
  Rat  3701 DTVLKLLLNGARHLGYTLCKQIGTLLAELR-----------EYNLEQQRRAQCETLSPDGLP--- 3751

  Fly    97 EEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNR 161
            ||     .|.:|   |:......|.|  :.|.::.:|...:...||  .|:|.....:|||:..:
  Rat  3752 EE-----QPQTT---KLKGKMQSRFD--MAENVVIVASQKRPLGGR--ELQLPSMSMLTSKTSTQ 3804

  Fly   162 QTKSGELVAILNGLKLDMSKLQIQPVAGQQNGN---------PPVQAVNPSVVSDAAAGRSCMIY 217
            :.....|..|:. |:.|..:...:   .:|.|.         ..:||....:.::|.|... |:.
  Rat  3805 KFFLRVLQVIIQ-LRDDTRRANKK---AKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQ-MVR 3864

  Fly   218 GGVRARMRLR-SSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGA 281
            .|.|||.:.: ::|.:||..||..          |..::|...:|....:|:.|.   :|...|.
  Rat  3865 EGQRARRQQQAATSESSNQSETSV----------RREESPMDVDQPSPSAQDTQS---IVVSDGT 3916

  Fly   282 AVPQTAPYPQQPPAPALARPLT--QVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVG 344
            ...:.....:.|..|.|:..|:  :::..|.|..:.
  Rat  3917 PQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKE----------------------------- 3952

  Fly   345 LPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRG 409
            |..|......|..|||.:                .:::.|.|..   |...|:
  Rat  3953 LEESHDQHAVLVLQPAVE----------------AFFLVHATER---ESKPPV------------ 3986

  Fly   410 RVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDED 474
                  .:||                  :.|.||:                         :|:..
  Rat  3987 ------RDTR------------------ESQLAHI-------------------------KDEPP 4002

  Fly   475 ALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFF 539
            .|.|.|                 ....|....||....:..|:.....|||.        .::|.
  Rat  4003 PLSPAP-----------------LTPATPSSLDPFFSREPSSMHISSSLPPD--------TQKFL 4042

  Fly   540 VDHNTRRTTFED-PRPGAPKGAKGVYGVPRAY---------ERSFRWKLSQFRYLCQSNALPSHI 594
            ....|.||.... .|......|.|.:.|...|         .:.||.:|.:.....:...:..|:
  Rat  4043 RFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHV 4107

  Fly   595 KITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFE 659
            :    |..:|||||.::.|....|::.||||:|.||||.|.||:.|||:.::|.|:.||||.||.
  Rat  4108 R----RDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFR 4168

  Fly   660 YANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIE 724
            .:..:..:..|||:|:.||:||.||||:||.:|.|:|..|.:...||..|||.:|.|.:...|:|
  Rat  4169 TSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDME 4233

  Fly   725 TIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTE 789
            :.|..||..|:::.:|::...|.:|.||.:.:..|.....:||.||....||||||:||:.|:.:
  Rat  4234 SEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQ 4298

  Fly   790 WRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQ 854
            .|||..|.:|...|||||.|::|...:..|.|:||||::.|:..:|::|.:.||.|..|..||.|
  Rat  4299 MRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQ 4363

  Fly   855 VVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCF 918
            :.|||:.:|..|...||:.|||||||.:||:.|||.|.|.||.|:|.|.:..:.| .||.:||||
  Rat  4364 IQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCF 4428

  Fly   919 NRLDLPPYKSYDQLVEKLTFAIEE-TEGF 946
            |:||||.|:|:::|...|..||:| :|||
  Rat  4429 NQLDLPAYESFEKLRHMLLLAIQECSEGF 4457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	26/130 (20%)
		WW	364..396	CDD:197736	3/31 (10%)
		HUL4	<395..946	CDD:227354	185/562 (33%)
Huwe1	XP_063136267.1	None