Protein Alignment Su(dx) and NEDD4

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001271267.1
• Gene: NEDD4 / 4734
• HGNCID: 7727
• Length: 1319
• Species: Homo sapiens
• Alignment Length: 1216
• Identity: 374/1216 - (30%)
• Similarity: 524/1216 - (43%)
• Gaps: 345/1216 - (28%)

  Fly     6 GLPAGAASGGMEAGQTVNGAGSASPTPTSSSGAG----ASGSANQGYHQLSVT------------ 54
            |..|...|||......::.:.|.:..|:..:..|    :..::|:.....:.|
Human   170 GSCASITSGGSYTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTD 234

  Fly    55 ------------IEEASLRNNGFLKPNPYVELLIDSKSKRKTD----------LVKNSYLPKWNE 97
                        |.:..:..|..:....|..|:|..:|...|.          |.|.||  :.:.
Human   235 PFVQDDLEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSY--QTSH 297

  Fly    98 EFTVLITPNSTLHFKVLDHSS---FRKDAMLGERI------------INLAHILQHYNGRCEFLE 147
            :|  :|:|:...|.:  |.:|   |...|:.|.|:            |...|       |...|:
Human   298 QF--IISPSEIAHNE--DGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLH-------RKGSLQ 351

  Fly   148 LTIDLFVTSKSDNRQT---KSGE---LVAI--------------LNG-LKLDMSKLQIQPVAGQQ 191
            ..|   |.|.:..|||   ||.|   .|::              .|| .|.:||::::...:...
Human   352 KKI---VLSNNTPRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYI 413

  Fly   192 NGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGG--------- 247
            .......|..||     :....|.|  .:...:....|..|.|.|..|..:..||.
Human   414 KLMHRTSACLPS-----SQNVDCQI--NINGELERPHSQMNKNHGILRRSISLGGAYPNISCLSS 471

  Fly   248 -DHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAP----------------------- 288
             .|..|...|            .|..::..:|:...|...:.
Human   472 LKHNCSKGGP------------SQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQ 524

  Fly   289 -----YPQQPPAPALARPLTQVYGALPENTQPAAV---------YLPAGGGA---------AVGP 330
                 ||.....|.|.||.|.....|...:..:.|         |||...|:         .:.|
Human   525 VDVPLYPLPTENPRLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEP 589

  Fly   331 PGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPT 395
            ..|.   ::||.....:.|..:|         .|||.|||.|.|..||.|||:|.:|.|.|::||
Human   590 GWVV---LDQPDAACHLQQQQEP---------SPLPPGWEERQDILGRTYYVNHESRRTQWKRPT 642

  Fly   396 P---------------------------------------------------------------- 396
            |
Human   643 PQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPS 707

  Fly   397 -------------------------------------------------------------LPPG 400
                                                                         ||||
Human   708 SNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPG 772

  Fly   401 WEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVT 465
            ||.::|.|||.||||||:|.|||.:|..:..:........::   |.|.|....:....|
Human   773 WEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS---SAGPQSQASTSDSGQ----- 829

  Fly   466 AQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPR------TQGQ-EVSLINE-GP 522
             ||||..|...|.||.|||.:...:.|.:|::|..:||.|||||      .:|: .:...|: ||
Human   830 -QVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGP 893

  Fly   523 LPPGWEIRYTAAGERFFVDHNTRRTTFEDPR--------PGAPKGAKGVYGVPRAYERSFRWKLS 579
            ||||||.|....|..|:::||.:||.:||||        |..|            |.|.::.|..
Human   894 LPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVP------------YSRDYKRKYE 946

  Fly   580 QF-RYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYE-LRRRLYIIFRGEEGLDYGGVSREW 642
            .| |.|.:.|.:|:..::.:.|.|:.||||.:||.:...: |:.||:|.|.||:|||||||:|||
Human   947 FFRRKLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREW 1011

  Fly   643 FFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFIGRFIAMALYHGRFIYSGFT 706
            |||:|.|:.||.|.||||:..:||:|||||.| ..|.|||.|||||||...||:|||:.:...|.
Human  1012 FFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFI 1076

  Fly   707 MPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGE 771
            .||||.||:|.:|:.|:|::|.|:||||.|:.:|  |...|:|.|.:|.|:.||...||||..|.
Human  1077 RPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN--DPTELDLRFIIDEELFGQTHQHELKNGGS 1139

  Fly   772 KERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDV 836
            :..||.:||:|||.|:.:||....|::|...|.|||.|::|.:.:|.|||.||||::||:.||||
Human  1140 EIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDV 1204

  Fly   837 EDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRF 900
            .||:.:|.|:: |:.|.:.:.|||:.|...|:|||.|||||||||.|||:.|||||.||||||.|
Human  1205 NDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSF 1269

  Fly   901 CIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            .:|:.|....|||:||||||||||||:|:::|.:||..|||.|:||
Human  1270 TVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	36/193 (19%)
		WW	364..396	CDD:197736	18/31 (58%)
		HUL4	<395..946	CDD:227354	267/695 (38%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..229		2/24 (8%)
		C2	<517..570	CDD:472691	9/52 (17%)
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		110/435 (25%)
		WW	611..643	CDD:197736	18/31 (58%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:11342538	716..726		0/9 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..780		7/24 (29%)
		WW	769..798	CDD:459800	20/28 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	796..834		8/46 (17%)
		WW	842..871	CDD:459800	12/28 (43%)
		WW	893..925	CDD:197736	17/31 (55%)
		HECTc	986..1315	CDD:214523	180/330 (55%)