DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and nedd4l

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_012815048.1	Gene:	nedd4l / 448382	XenbaseID:	XB-GENE-489248	Length:	1290	Species:	Xenopus tropicalis

Alignment Length:	1287	Identity:	376/1287 - (29%)
Similarity:	525/1287 - (40%)	Gaps:	392/1287 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AGQTVNGAGSASPTPTSSSGAGASGSANQGYHQLSVTIEEASLRNNGFLKPNPYVELLIDSKSKR 82
            |..|:.....:.|.....|..|.|....:|..:.|.::....|.||..::|.....:.|..:...
Frog    34 AFHTLPRRNGSHPFSRHGSECGESELPEEGALKRSTSMFIPQLLNNIDIRPTRSSSVQISLQRNS 98

  Fly    83 KTDLVKNSYLPKW------------NEEFTVLITPNSTLHFKVLD----HSSFRKDAMLGERIIN 131
            ....|.....|::            ||.:...:..||:.....||    ....|:|.
Frog    99 ANGHVDEFEAPEYPDEALACDFGDFNEHYISAVRKNSSSASSPLDTPGNSPPQRRDT-------- 155

  Fly   132 LAHILQHYNGRCEFL-ELTIDLFVTSK------SDNRQ----TKSGELVAILNGLKLDMSKLQ-- 183
               ..|..||...|| .||:...|...      :|.::    |.||:..   :|:::....|.
Frog   156 ---TRQPINGAAPFLPRLTVRPIVEQNGHINCAADMQEEVSITTSGQNT---SGIRIKRQPLSPD 214

  Fly   184 ------IQPVAGQQNGN---PPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSN-GGET 238
                  :.|....|||:   |...::.....:..:.|:.|.::      ...:|.:|||| |||.
Frog   215 IRQVRLLSPCQENQNGSNTEPRRWSLQHLPDTSGSPGKRCFVF------QLQQSQTGNSNMGGEY 273

  Fly   239 RSPLPNGGGDH---------RRSTQAP---------PV-----------------------WEQQ 262
            ........||.         .|||..|         ||                       .|:.
Frog   274 NFGFTGTKGDRLVRYPRIRLERSTSYPLQPRPESTSPVENGLSSESGKCKKDYAEILPNDSRERP 338

  Fly   263 QQ---------QSQNQQQP---LRMVNGS-------GAAVPQTA-----------------PYPQ 291
            .|         |..|.:||   :|:...|       |..||:.:                 |...
Frog   339 SQGQGCTFKIRQESNVRQPHFRIRVTRSSEEQGTEEGQDVPRNSALGKATTRDDFLGQVDVPLNH 403

  Fly   292 QPPA-PALARPLT-------------QVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPG 342
            .|.. |.:.||.|             :|.|.|    :....|||. .|.............||..
Frog   404 LPTEDPTMERPYTFKDFLLRPRSHKSRVKGFL----RLKMAYLPK-NGMQEEENNEQREESEQAW 463

  Fly   343 VGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKP------------- 394
            ..:..:.|:.|..|..||  .|:|.|||.::|..||.|||:||.::|.|::|
Frog   464 DVVDSNDSSSPHQQELPA--PPMPPGWEEKVDNLGRTYYVNHNNKTTQWQRPSLVDVTSESDSNI 526

  Fly   395 ----------------------------------------------------------------- 394

Frog   527 RHIQQEAHRVFRSRRHISEDLEPDHIEGGADVPEPWETISEEMTLTTDTLNQSLPPPASPDSRAS 591

  Fly   395 ----------------------------------------------------------------- 394

Frog   592 ALELSEELNRRLQISSESNGEQFSSIIQTAWERQKQREPSTRLRSCSVTDGVAEQAHLSLPSVST 656

  Fly   395 -----------------------TP-LPPGWEIRKDGRGRVYYVDHNTRKTTWQRP--------- 426
                                   || ||.|||.|||.:||.|||:||.|.|||.||
Frog   657 GRARSSTVTGGEDSTPTVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIVQHAEDGA 721

  Fly   427 ---NSERLMHFQHWQGQRAHVVS----------QGNQRY---------LYSQQQQQPTAVTAQVT 469
               .|....|....|.:|...:|          :|.:.:         |.:.|..||:...:...
Frog   722 VGSTSNSSNHLSEPQIRRPRSLSSPTVTLSAPLEGAKDFPVRRAVKDTLSNPQSPQPSPYNSPKP 786

  Fly   470 QDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQ-----GQEVSL-INE-GPLPPGW 527
            | .:.|...||.|||.:|..:.|.:|::|..:||.|||||.:     ..:.|| .|: |||||||
Frog   787 Q-HKGAQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRTKASLNPNDLGPLPPGW 850

  Fly   528 EIRYTAAGERFFVDH-------------------NTRRTTFEDPRPGAPKGAKGVYGVPRAYERS 573
            |.|....|..|::||                   :|:.|.:||||...|    .:.|....|.|.
Frog   851 EERIHGDGRTFYIDHRSPGLRCRDTGTSCSVPPYDTKITQWEDPRLQNP----AITGPAVPYSRE 911

  Fly   574 FRWKLSQFRYLCQSNA-LPSHIKITVTRQTLFEDSYHQIMRLPAYE-LRRRLYIIFRGEEGLDYG 636
            |:.|...||...:..| :|:..::.:.|..:||:||.:||.:...: |:.||:|.|..|:|||||
Frog   912 FKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG 976

  Fly   637 GVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFIGRFIAMALYHGRF 700
            ||:||||||||.|:.||.|.||||:..:||:|||||.| ..|.|||.||.||||...:|::||:.
Frog   977 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRIAGLAVFHGKL 1041

  Fly   701 IYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHE 765
            :...|..||||.||.|::|:||:|::|.|:||||.|:.:|  |...|:|.|.:|.|..||....:
Frog  1042 LDGFFIRPFYKMMLGKQITLKDMESVDSEYYNSLKWILEN--DPTELDLRFCIDEENFGQTYQVD 1104

  Fly   766 LKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCG 830
            ||.||.:..||.:||.|||.|:.:||....:::|...|||||.|::|::.:|.|||.||||::||
Frog  1105 LKPNGSEMVVTNDNKREYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCG 1169

  Fly   831 MQDVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGS 894
            :.||||.||:::|:|:: |..|...:.|||:.|...|.|||.|||||||||.|||:.|||||.||
Frog  1170 LGDVDVNDWRQHTLYKNGYCPNHPAIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGS 1234

  Fly   895 NGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            ||||.|.||:.|....|||:||||||||||||.|::.|.|||..|:|..:||
Frog  1235 NGPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYDSFEDLREKLLMAVENAQGF 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	28/151 (19%)
		WW	364..396	CDD:197736	16/197 (8%)
		WW	397..426	CDD:278809	19/28 (68%)
		WW	478..509	CDD:197736	14/30 (47%)
		WW	522..554	CDD:197736	17/50 (34%)
		HECTc	594..946	CDD:238033	184/354 (52%)
		HECTc	620..946	CDD:214523	176/327 (54%)
nedd4l	XP_012815048.1	C2	<389..442	CDD:301316	9/56 (16%)
		WW	485..513	CDD:238122	14/27 (52%)
		WW	683..712	CDD:278809	19/28 (68%)
		WW	796..826	CDD:238122	14/29 (48%)
		WW	845..896	CDD:197736	17/50 (34%)
		HECTc	933..1287	CDD:238033	186/356 (52%)
		HECTc	957..1286	CDD:214523	177/330 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940