DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and hyd

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	194/958 - (20%)
Similarity:	326/958 - (34%)	Gaps:	279/958 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 HILQHYNGRCEFLELTIDLFVTSKSDNR-QTKSGELVAIL----------NGLKLDMSKLQIQPV 187
            |:||. |.:.:.|...:.|.||:.::|. .|..|:..:|.          |.||.:....:..|:
  Fly  2063 HLLQP-NSKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPI 2126

  Fly   188 AGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRS 252
            ...:.|       :.:|.:.|.......||      ::|:...|:               |..:|
  Fly  2127 DSSKTG-------DGNVTNKAEGSTDSNIY------VQLKKKQGS---------------DDFKS 2163

  Fly   253 TQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAA 317
            .:     |....||:.::..|...:.|   :|.|:...:...|                 |:|..
  Fly  2164 HK-----EADGNQSKYEKVVLMETDDS---LPSTSKSTEALMA-----------------TRPEV 2203

  Fly   318 VYLPAGGGAAVGPPGVAGPPI--------------------------EQPGVGLPVSQSTDPQLQ 356
            :..|  ..|:|.|...|...|                          ||........:||...|.
  Fly  2204 IIAP--NKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLL 2266

  Fly   357 TQPA--------DDEPLP------AGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIR--- 404
            ..||        :...||      :.|::.||.:||.:..|     ...|..:.||   |:|
  Fly  2267 LFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDD-----VGMEHGSVLP---ELRGFP 2323

  Fly   405 -KDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQ---------GNQRYLYSQQQQ 459
             |:.|.|        |.....|...:|.:.....:..|..::.|         |||    |::.|
  Fly  2324 VKEMRFR--------RHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQ----SRRIQ 2376

  Fly   460 QP-TAVTAQVTQDDEDALG-------------------PLPDGWEKKIQSDNRVYFVNH----KN 500
            .| |....:||..||...|                   .:|:....::.:::..|.|..    ::
  Fly  2377 PPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRS 2441

  Fly   501 RTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYG 565
            ||..... |.|.   :|...|   ...:|.:.:|.|        |:....|.||..|..:
  Fly  2442 RTVSGSS-RDQS---TLQRRG---SNSKILWRSARE--------RKALNLDARPYTPPNS----- 2486

  Fly   566 VPRAYERSFRWKLSQFRYLCQSNALPSHIK--ITVTRQTLFEDSYHQI---------------MR 613
                                ..||.|..:.  ::|..|.:.|..|.:|               :.
  Fly  2487 --------------------SDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLE 2531

  Fly   614 LPAYELRRRLYIIFRGE-------EGLDYGGVSR--EWFFLLSHEVLNPMYCLFEYANKNNYSLQ 669
            :|..:|   |.:|...|       |.::.....:  |.....|....:|...:.:..:.:|..|.
  Fly  2532 IPTPQL---LSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLF 2593

  Fly   670 INPA---------SYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725
            .:|.         .:.:.:.:..|:.|||.|.:.|.....:.........|.:|.:|:...|:..
  Fly  2594 YSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAF 2658

  Fly   726 IDPEFYNSLIWVKDNNIDECG------LELWFSVDF---EVLGQIIHHELKENGEKERVTEENKE 781
            .||..|.|...:..|...:.|      :||.|.:|.   |..|   :.||...|....||..|..
  Fly  2659 FDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG---NRELIPGGRDVAVTSSNIF 2720

  Fly   782 EYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTI-- 844
            ||:...||:|:.:..|:..:...:|..:|:|...:......:|.|:|.|:.|::|     :|:
  Fly  2721 EYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINV-----STLIS 2780

  Fly   845 YRHYNRNS--------KQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVG--GFAELMGSNGPQR 899
            |..:|..|        |...|||..|.:.:..:|..|:.|.||:..:|..  ||.       |..
  Fly  2781 YTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQ-------PLP 2838

  Fly   900 FCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETE-GF 946
            ....:...::.||.::||.:||.:|.|.|...|..|:..||:... ||
  Fly  2839 SVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	12/49 (24%)
		WW	364..396	CDD:197736	9/37 (24%)
		WW	397..426	CDD:278809	8/32 (25%)
		WW	478..509	CDD:197736	5/34 (15%)
		WW	522..554	CDD:197736	5/31 (16%)
		HECTc	594..946	CDD:238033	91/408 (22%)
		HECTc	620..946	CDD:214523	84/365 (23%)
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/65 (17%)
		HECTc	2589..2885	CDD:238033	77/310 (25%)
		HECTc	2589..2884	CDD:214523	77/309 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830