DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and ube3a

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_012812141.1	Gene:	ube3a / 407881	XenbaseID:	XB-GENE-948557	Length:	908	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	155/513 - (30%)
Similarity:	252/513 - (49%)	Gaps:	72/513 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 QDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSL----------------- 517
            :|||    |:|:..|..:|.     .:..:.|..  :.||....|..|
Frog   429 EDDE----PVPESSELTLQE-----LLGEERRNK--KGPRVDPLETELGVKSIDCRKPLIPFEEF 482

  Fly   518 INEGPLPPGWEI--RYTAAGERFFVDHNTRRTTFEDPRP---GAPKGAKGVYGVPRAYERSFRW- 576
            :|| ||....|:  .||     ||......:.:|. ..|   .|.....|:|     |:...|.
Frog   483 VNE-PLNDVLEMDKDYT-----FFKVETENKFSFM-TCPFILNAVTKNLGLY-----YDNRIRMY 535

  Fly   577 ---KLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQI----MRLPAYELRRRLYIIFRGEEGLD 634
               :::....|.|...|..::::.|.|..:.:|:..::    |..|| :|:::||:.|.||:|:|
Frog   536 SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPA-DLKKQLYVEFEGEQGVD 599

  Fly   635 YGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGR 699
            .||||:|:|.|:..|:.||...:|.|.....:| ..||:|:.....   |..||..:.:|:|:..
Frog   600 EGGVSKEFFQLVVEEIFNPDIGMFTYDESTKHS-WFNPSSFETEGQ---FTLIGIVLGLAIYNNC 660

  Fly   700 FIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSL--IWVKDNNIDECGLELWFSV-DFEVLGQI 761
            .:...|.|..|::::.||.|.:|:....|..|.||  :...:.|::| .:.:.|.: ..::.|..
Frog   661 ILDVHFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKELLEYEGNVEE-DMMMTFQISQTDLFGNP 724

  Fly   762 IHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY-FDERELE 825
            :.|:|||||:|..:|.||::|:::|.|::.:.:.:|:|.|.|..||:.|.....||| |...|:|
Frog   725 LMHDLKENGDKIPITNENRKEFVSLYTDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIE 789

  Fly   826 LILCGMQDVDVEDWQRNTIY-RHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFA 889
            |::||.:::|.:..:..|.| ..|.|:|..:..||:.|.....|::...|||.|||.|.||||..
Frog   790 LLICGSRNLDFQALKDTTEYDGGYTRDSNIIKEFWEIVNSFTEEQKRLFLQFTTGTDRAPVGGLG 854

  Fly   890 ELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            :|       :..|.|.|.:| .||.||||||.|.||.|.:.::|.|:|..||...:||
Frog   855 KL-------KMIIAKNGPDTDRLPTSHTCFNVLLLPEYSNKEKLKERLLKAITYAKGF 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	5/30 (17%)
		WW	522..554	CDD:197736	8/33 (24%)
		HECTc	594..946	CDD:238033	122/361 (34%)
		HECTc	620..946	CDD:214523	115/331 (35%)
ube3a	XP_012812141.1	AZUL	58..112	CDD:374628
ube3a	XP_012812141.1	HECTc	556..906	CDD:238033	124/363 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910