Protein Alignment Su(dx) and Nedd4

DIOPT Version :9

• Sequence 1: NP_001259898.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 1169
• Identity: 345/1169 - (29%)
• Similarity: 481/1169 - (41%)
• Gaps: 392/1169 - (33%)

  Fly     2 ADGNGLPAGAASGGMEAGQTVNGAGSASPTP--TSSSGAGASGSANQ---GY------------- 48
            |..:||.|.||.....:..:|.|.....|.|  .::|.||...:..:   ||
  Fly     3 ARSSGLVAAAALPVPSSSSSVAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSG 67

  Fly    49 ---HQLSVTIEEASL-RNNGFLKPNPYV---------ELLIDS---KSKRKTDLVKNSYLPKWNE 97
               |...|.:...|| :.:.|...:|||         ::.|||   |:|:||      ..|.|||
  Fly    68 DSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKT------LNPTWNE 126

  Fly    98 EFTVLITPNS-TLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNR 161
            ||...:.|:. .|.|:|.|.:...:|..||...:.|.::.....||      ||
  Fly   127 EFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGR------TI----------- 174

  Fly   162 QTKSGELVAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVR----- 221
                                       |:|:     ..:.|.    .:.|....|.|.:|
  Fly   175 ---------------------------GEQS-----YTLRPR----RSVGAKSRIKGTLRIYHAF 203

  Fly   222 ---ARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAV 283
               .|.:...|||||:|                      .||.              |..:.|..
  Fly   204 IRETREQSEPSSGNSDG----------------------EWEH--------------VEATNAGE 232

  Fly   284 PQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVS 348
            ....|:|                             .|.||
  Fly   233 TSAQPHP-----------------------------FPTGG------------------------ 244

  Fly   349 QSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPL---------------- 397
                         .:.||||||.|.|..||.|||:|..|:|.|::||.|
  Fly   245 -------------HDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDF 296

  Fly   398 ----------------------------------------------PPGWEIRKDG---RGRVYY 413
                                                          ||......:|   :..:.|
  Fly   297 QRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQY 361

  Fly   414 ---------VDHN---------------------------------------------TRKTT-- 422
                     |||.                                             ||:..
  Fly   362 RAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGN 426

  Fly   423 ------WQRPNSERLMHF---QHWQGQRA-----------HVVSQGNQRYLYSQQQQQPT----- 462
                  ||:....:.|..   ||.|.|:.           |...:...|....|||.:|:
  Fly   427 MAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTD 491

  Fly   463 ------------AVTAQVTQDDEDAL-----------GPLPDGWEKKIQSDNRVYFVNHKNRTTQ 504
                        ..|.:.:::|..|:           .|||..|..::..:.|.:|::|.:|.|.
  Fly   492 HTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHASRRTT 556

  Fly   505 WEDPRTQGQEVSLINE--------GPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAK 561
            |.||| .|:...:.|:        ||||.|||.|....|..|::|||||.|.:||||...|
  Fly   557 WIDPR-NGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNP---- 616

  Fly   562 GVYGVPRAYERSFRWKLSQFR-YLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYE-LRRRLY 624
            .:.|....|.|.::.|...|: ::.:...:|:..:|.:.|.::.||||..|..:...: |:.:|:
  Fly   617 NIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDSYRIISSVTKTDLLKTKLW 681

  Fly   625 IIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPAS-YVNPDHLQYFKFIG 688
            :.|.||.||||||::||||:|||.|:.||.|.||||:..:||:||||..| ..|.:||.||||||
  Fly   682 VEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIG 746

  Fly   689 RFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSV 753
            |...||:|||:.:.:.|..||||.||.|.:.:||:|::|.|:||||:|:|:|  |...|||.|.:
  Fly   747 RIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWIKEN--DPRILELTFCL 809

  Fly   754 DFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY 818
            |.:|.||...||||..|....||.|||:|||.|:.|||....:::|..:||:||..::||..:|.
  Fly   810 DEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKI 874

  Fly   819 FDERELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCR 882
            |||.||||::||:|::||:||:.||:|: .|:.|...:.|||:.|....||.|:|||||||||.|
  Fly   875 FDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSR 939

  Fly   883 VPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            ||:.||.||.||||||.|.|||.|.....||:||||||||||||:.|.||.:||..|||.::||
  Fly   940 VPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGF 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	35/154 (23%)
		WW	364..396	CDD:197736	18/31 (58%)
		WW	397..426	CDD:278809	12/155 (8%)
		WW	478..509	CDD:197736	11/30 (37%)
		WW	522..554	CDD:197736	18/31 (58%)
		HECTc	594..946	CDD:238033	184/354 (52%)
		HECTc	620..946	CDD:214523	176/327 (54%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	41/191 (21%)
		WW	248..277	CDD:278809	17/28 (61%)
		WW	531..560	CDD:278809	9/28 (32%)
		WW	581..613	CDD:197736	18/31 (58%)
		HECTc	650..1003	CDD:238033	184/354 (52%)
		HECTc	674..1003	CDD:214523	177/330 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446997
Domainoid	1	1.000	50	1.000	Domainoid score	I3372
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13657at50557
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	P	PTHR11254
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.780