DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Herc4

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	116/387 - (29%)
Similarity:	191/387 - (49%)	Gaps:	38/387 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 YGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFR 628
            ||:|          :|||            |.:.|||:.|.:||..::......:|::.|.|.|.
  Fly   707 YGMP----------ISQF------------IVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFH 749

  Fly   629 GEEGLDYGGVSREWFFLLSHEVLNPMYCLF-EYANKNNYSLQINPASYVNPDHLQYFKFIGRFIA 692
            |||..|.|||.:|:|.||..::|:|.|.:| ||  :.:..|.....::...:  .|| .||....
  Fly   750 GEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEY--EQSRLLWFADLTFETEN--MYF-LIGVLCG 809

  Fly   693 MALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECG--LELWFSVDF 755
            :|:|:...|...|.:..:|::|.|.:.:.|:..:.|...||:..:.|...|:..  .:|.|.:..
  Fly   810 LAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISR 874

  Fly   756 EVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFD 820
            :|.|:.....||.||.:..||.||::|::.|..::...:.:|.....|.:||.:|.....:..|.
  Fly   875 DVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQ 939

  Fly   821 ERELELILCGMQDVDVEDWQRNTIYRH-YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVP 884
            ..||..::.|.:|.|.:..|.|..||. |......:.|||:.:.:....::...|.|:||:.|:|
  Fly   940 PEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIP 1004

  Fly   885 VGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            :.|...|       :..|:....|.:||.:|||||.||||.||:.::|..||..||::|:||
  Fly  1005 IQGMKAL-------KLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGF 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033	108/355 (30%)
		HECTc	620..946	CDD:214523	100/329 (30%)
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	110/357 (31%)
		HECTc	739..1059	CDD:214523	101/331 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740