DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and CG3356

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	125/433 - (28%)
Similarity:	209/433 - (48%)	Gaps:	44/433 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 RRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIK-------------- 595
            |..|.||...|.|...|.:..:....|..|....::...:.||....|.::
  Fly   700 RDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSV 764

  Fly   596 -ITVTRQTLFEDSYHQIMRLPAYELRRRLYIIF-----RGEEGLDYGGVSREWFFLLSHEVLNPM 654
             |||.|..|:||:|.::......:||.:..|.|     ..|.|:|.|||.||:...|.....:|
  Fly   765 LITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDP- 828

  Fly   655 YCLFEYANKNNYSLQINPASYVNP-------DHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKR 712
                   |:..:.:..:...|.||       |:.:::.||||.:..::|....:.......|..:
  Fly   829 -------NRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTK 886

  Fly   713 MLNK--KLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERV 775
            :..|  .:.|..:.::|||.|.:|:::||.:.|...|.|.|:|....|||....|||..|:...|
  Fly   887 LAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPV 951

  Fly   776 TEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQ-DVDVEDW 839
            |..|:.||:.|:.::::...|.:....|.:|.:.|:|:|||..|..:||::::.|.: .:|:||.
  Fly   952 TNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDL 1016

  Fly   840 QRNTIY-RHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIE 903
            :::..| ..::.....:|.||:.:...|:.:|.:||:|||...|.|:.||.:|   :.|  |.|:
  Fly  1017 KKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL---DPP--FFIQ 1076

  Fly   904 KVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            ..|....||.:.||.|.|.|||:|:.:|:.|||.:||:...||
  Fly  1077 NTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736	4/8 (50%)
		HECTc	594..946	CDD:238033	111/382 (29%)
		HECTc	620..946	CDD:214523	102/341 (30%)
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	113/367 (31%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	103/343 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740