Protein Alignment Su(dx) and Smurf

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 1112
• Identity: 344/1112 - (30%)
• Similarity: 485/1112 - (43%)
• Gaps: 270/1112 - (24%)

  Fly    47 GYHQLSVTIEEAS--LRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEF--------- 99
            |.|::.:||..|.  .|.:.|..|:|:.::.:|...: ..|::.|:|..||||..:
  Fly    11 GTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDA 75

  Fly   100 -TVLITPNSTLH-----------------------FKVLDHSSFRKD---AMLGERIINLAHILQ 137
             |:.:.....:|                       |:.||......|   .:.|:.||:|.
  Fly    76 ITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLL---- 136

  Fly   138 HYNGRCEFLELTI-----DLFVTSKSDN-----------RQTKSGELVAILNGLKLDMSKLQIQP 186
            ..:|......|.|     |:...|:.|:           |:|.:|.:..:.:..|........||
  Fly   137 SKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQP 201

  Fly   187 -VAGQQNGNPPVQAVNP----SVVSDAAAG----RSC--MIYGGVRAR----------------- 223
             |.|..:...|.|..|.    |....|.||    .:|  ::..|.|:|
  Fly   202 GVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEIL 266

  Fly   224 ---------------------MRLRSSSGNSNGGETRSPLPNG-----------------GGD-- 248
                                 .:..||:.:|.||.|....|..                 ..|
  Fly   267 SSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNH 331

  Fly   249 -----HRRSTQAPP------VWEQQQQQSQNQQQPLRMVNGSG-AAVPQTAP------------- 288
                 |:.:..|||      ...||...:.|.|......|||| ||.||:|.
  Fly   332 VKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTS 396

  Fly   289 ---------YPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVG 344
                     :.|.||.|.::.|.:....|......|.|...|||.|.     |........||
  Fly   397 PSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGG-----GSRSYTAATPG-- 454

  Fly   345 LPVSQSTDPQLQTQPADDEPLPAGWEIRLDQ---------------YGRRYYVDHNTRSTYWEKP 394
                |.:..:...|..::    :....|..:               .|:||.......:....:|
  Fly   455 ----QRSQRRSSRQQGEE----SSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARP 511

  Fly   395 -TPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQ 458
             ..||||:|:|...:|:||:....|..:||..|...|....||
  Fly   512 FLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQH---------------------- 554

  Fly   459 QQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPL 523
                 :|.       ||:||||.|||::..:..|||||:|.|||||:.|||..|..:.:|..|.:
  Fly   555 -----LTL-------DAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTV 607

  Fly   524 PPGWEIRYTAAGE--------------------------RFFVDHNTRRTTFEDPR---PGAPKG 559
            ||      |:|..                          .......|..||...|.   |..|:|
  Fly   608 PP------TSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQG 666

  Fly   560 -AKGVYGVPRAYERSFRWKLSQFRYLCQSNALPS-HIKITVTRQTLFEDSYHQIMRLPAYELRRR 622
             .:|...:|: |.|....||...|...|:....| |.::.|:|..:||:||..||::.|.::|:|
  Fly   667 LLEGADLLPK-YRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKR 730

  Fly   623 LYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFI 687
            |.:.|:||||||||||:|||..|||.|:|||.|.||:|:..::|:|||||.|.||||||.||.|:
  Fly   731 LMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFV 795

  Fly   688 GRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFS 752
            ||.:.:|::||..:..|||.||||::|||.:|:.|||.:||:.:.||.|:.::||... :|..||
  Fly   796 GRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFS 859

  Fly   753 VDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLK 817
            |:....|.::.||||..|....||||||.||:.|...:|..||||||.....:||.|::|...|:
  Fly   860 VENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLR 924

  Fly   818 YFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCR 882
            .||||||||::.|:..:||.||:.||..:|....:.||:||||.|....:|.||||||||||:.|
  Fly   925 PFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSR 989

  Fly   883 VPVGGFAELMGSN---GPQRFCIEKVGKETW--LPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEE 942
            ||:.||..|.||.   ||:.|.|........  ||::||||||:|||||::|..|.:|||.|:||
  Fly   990 VPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEE 1054

  Fly   943 TEGFCQE 949
            |.||..|
  Fly  1055 TCGFAVE 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	35/179 (20%)
		WW	364..396	CDD:197736	5/47 (11%)
		HUL4	<395..946	CDD:227354	242/586 (41%)
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028	24/120 (20%)
		PRP40	155..>283	CDD:227435	22/127 (17%)
		WW	169..198	CDD:459800	4/28 (14%)
		WW	514..546	CDD:197736	13/31 (42%)
		WW	562..594	CDD:197736	19/31 (61%)
		HECTc	702..1058	CDD:238033	178/356 (50%)