DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Hectd1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_006240148.1	Gene:	Hectd1 / 362736	RGDID:	1561653	Length:	2610	Species:	Rattus norvegicus

Alignment Length:	1263	Identity:	259/1263 - (20%)
Similarity:	407/1263 - (32%)	Gaps:	404/1263 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PAGAASGGMEAGQTVNGAGSASPT-----------------PTSSSGA-GASGSANQGYHQLSVT 54
            |....|......||..|:.|::.|                 |.||..| |.|.:.:.|.  :||:
  Rat  1425 PIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRAPGESSAISMGI--VSVS 1487

  Fly    55 IEEAS----LRNNGFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFKVLD 115
            ..:.|    |.|.......|    |..|.|.|   |..:|.|.......:....||
  Rat  1488 SPDVSSVSELTNKEAASQRP----LSSSASNR---LSVSSLLAAGAPMSSSASVPN--------- 1536

  Fly   116 HSSFRKDAMLG---ERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGELVAILNGLKL 177
             .|.|:.:.|.   .|:.|:|......|     :.|:     .|.|||.          .|.|..
  Rat  1537 -LSSRETSSLESFVRRVANIARTNATNN-----MNLS-----RSSSDNN----------TNTLGR 1580

  Fly   178 DMSKLQIQPVAGQQN-------GNPPVQAVNPSVV---SDAAAGRSCMIYGGVRARMRLRS---- 228
            ::......|:.|.|:       |......::.|.|   |:.|...:.:..|...:.....|
  Rat  1581 NVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTST 1645

  Fly   229 SSGNSNGGETRSPLPNGGGDHRRST---------QAP-PVWEQQQQQSQNQQQ------------ 271
            ||.:..|.|....|.:.....|.||         ..| |..|..:.:..||:.
  Rat  1646 SSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYEEVMILRRP 1710

  Fly   272 PLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLPAGGG----------- 325
            .|:...||.:.|...|...|.|..|:.|       |:.|...|....|...||.
  Rat  1711 SLQRRAGSRSDVTHHAVTSQLPQVPSGA-------GSRPIGEQEEEEYETKGGRRRTWDDDYVLK 1768

  Fly   326 ---AAVGP-----PGVAG----PPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGR 378
               :|:.|     ||...    ..:|.|..|.|.|:..: :::..|:....|    .:::...|.
  Rat  1769 RQFSALVPAFDPRPGRTNVQQTTDLEIPPPGTPHSELLE-EVECTPSPRLAL----TLKVTGLGT 1828

  Fly   379 RYYVD---HNTRST---YWEKPTPLPPGWEIRKDGRGRVYYVDH---------------NTRKTT 422
            ...|:   .|.|||   |.:|...|.....::.|...|::...:               |.:...
  Rat  1829 TREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYREMKDSDKEKENGKMGC 1893

  Fly   423 W------------QRPNSERLMHFQ---------HWQ---------------------------G 439
            |            :.|.::.:.:.|         ||:                           |
  Rat  1894 WSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHG 1958

  Fly   440 QRAHVVSQGNQRYLYSQQ-----QQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFV--N 497
            .|:. ::||....|.|..     ::||.|....         |..|.|.|..:|....:|.|  :
  Rat  1959 TRSG-LNQGASSSLQSSDILNLTKEQPQAKAGN---------GQNPCGVEDVLQLLRILYIVASD 2013

  Fly   498 HKNRTTQWEDPRTQGQ----------------------EVSLINEGPLPPGWEIRYTAAGERFFV 540
            ..:|.:| ||...|.|                      |...:..|.| |.|..:.|:... |.:
  Rat  2014 PYSRISQ-EDGDEQPQFTFPPDEFTSKKITTKILQQIEEPLALASGAL-PDWCEQLTSKCP-FLI 2075

  Fly   541 DHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLS-------QFRYLCQSNALPSHIKITV 598
            ...||:..|.....||.:....:.....|.....|...|       :||.     ....|.::.|
  Rat  2076 PFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRV-----GRLKHERVKV 2135

  Fly   599 TRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEV----LNPMYCLFE 659
            .|.....:....:|::.| :.:..|.:.|.||||... |.:.|::.|::.|.    |....|...
  Rat  2136 PRGESLMEWAENVMQIHA-DRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGTWLCDDN 2198

  Fly   660 YANKNNYSLQIN-----PASYV-------------NPDHLQ----YFKFIGRFIAMALYHGRFIY 702
            :.:..:..:.:.     |..||             :.|.|:    .|.|:|.|:|..:...|.:.
  Rat  2199 FPDDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVD 2263

  Fly   703 SGFTMPFYKRM------------------------------------------------------ 713
            ...:.||:|.|
  Rat  2264 LPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFI 2328

  Fly   714 -----------LNKKLTIKDIETIDPEFYNSLIWVKD---------------------------- 739
                       .|..||.:|.|.::|.....|..:||
  Rat  2329 LDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQELVL 2393

  Fly   740 ---------NNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRG 795
                     .:|::.||...|.....:.| ....:||.:||.|.:|.:|.|||:.||.::.|..|
  Rat  2394 KNPSGSGPPLSIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTG 2457

  Fly   796 IEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRH------YNRNSKQ 854
            |::|.:.|.:|||:|.|:|.|..|...|:::||||.|.   ..|....|..:      |.|:|..
  Rat  2458 IQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPG 2519

  Fly   855 VVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKV-GKETWLPRSHTCF 918
            .:.|.:.:....:::|...|||.||...:|.||.|.|    .|:...:.|| ..:...|..:||.
  Rat  2520 FLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANL----HPRLTVVRKVDATDASYPSVNTCV 2580

  Fly   919 NRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            :.|.||.|.|.:.:.|:|..|..| :||
  Rat  2581 HYLKLPEYSSEEIMRERLLAATME-KGF 2607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	27/131 (21%)
		WW	364..396	CDD:197736	9/37 (24%)
		WW	397..426	CDD:278809	5/55 (9%)
		WW	478..509	CDD:197736	10/32 (31%)
		WW	522..554	CDD:197736	8/31 (26%)
		HECTc	594..946	CDD:238033	108/486 (22%)
		HECTc	620..946	CDD:214523	104/460 (23%)
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560
		ANK repeat	366..393	CDD:293786
		ANK	369..479	CDD:238125
		ANK repeat	396..426	CDD:293786
		ANK repeat	428..457	CDD:293786
		F5_F8_type_C	1107..1240	CDD:304887
		MIB_HERC2	1277..1335	CDD:284184
		HECTc	2131..2608	CDD:238033	110/488 (23%)
		HECTc	2155..2607	CDD:214523	104/461 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900