DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Herc3

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001102101.1	Gene:	Herc3 / 362377	RGDID:	1307803	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	112/370 - (30%)
Similarity:	191/370 - (51%)	Gaps:	25/370 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   584 LCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSH 648
            |.:|..|..|::    |..|..|:..::......:|::.|.:||.||||:|.|||::|:|.||..
  Rat   696 LARSPFLVLHVR----RNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLK 756

  Fly   649 EVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRM 713
            |:|||:|.:|.|...:|. |..:...:|  :| .:|..||....:|:|:...:...|.:..||::
  Rat   757 ELLNPIYGMFTYYQDSNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKL 817

  Fly   714 LNKKLTIKDIETIDPEFYNSLIWVKD---NNIDE--CGLELWFSVDFEVLGQIIHHELKENGEKE 773
            ||.|.:::|::.:.|....||..:.|   .:|:|  |   |.|:|..|..|.|...:|...|::.
  Rat   818 LNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFC---LNFTVCRESYGVIEQKKLIPGGDRV 879

  Fly   774 RVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVED 838
            .|.::|::|::.....:.....:.:....|..||.:|...:.|:.|...||..::.|..:.:.|:
  Rat   880 AVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYNWEE 944

  Fly   839 WQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCI 902
            .:...:|: .|:.....|..||:...|...||:.|.|.|:||:.|:|:.|.|.|       :..|
  Rat   945 LEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRFLLFLTGSDRIPIYGMASL-------QIVI 1002

  Fly   903 EKVGK-ETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            :.... |.:||.:|||:|.||||.|.|.:.:..:||.|::..|||
  Rat  1003 QSTATGEDYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGF 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033	106/358 (30%)
		HECTc	620..946	CDD:214523	102/332 (31%)
Herc3	NP_001102101.1	ATS1	2..331	CDD:227511
		RCC1	313..377	CDD:395335
		HECTc	702..1048	CDD:238033	110/364 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810