DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Ube3c

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_038964472.1	Gene:	Ube3c / 362294	RGDID:	1559986	Length:	1083	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	121/373 - (32%)
Similarity:	195/373 - (52%)	Gaps:	35/373 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 IKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRG-----EEGLDYGGVSREWFFLLSHEVLNP 653
            |.:|:.|..::||:|.::......:|::|:.:....     |.|:|.||:.||:...|.....||
  Rat   723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNP 787

  Fly   654 MYCLFEYANKNNYSLQINPAS--YVNPDHLQYFKFIGRFIAMALYHGRFI---YSGFTMPFYKRM 713
            ....|:..|:.  .|..|||:  .|.....:::.|:||.:..|||....:   ::||   |..::
  Rat   788 NQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGF---FLSKL 847

  Fly   714 L--NKKLTIKDIETIDPEFYNSLIWVK--DNNIDECGLELWFSVDFEVLGQIIHHELKENGEKER 774
            |  :..:.|..:.::|||.|.:|:::|  :.:::|.||.  |:|....||:....|||..|:...
  Rat   848 LGTSADVDIHHLASLDPEVYKNLLFLKSYEEDVEELGLN--FTVVNNDLGEAQVVELKFGGKDIP 910

  Fly   775 VTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQ-DVDVED 838
            ||..|:..||.|:.::|:.:.|......|.:|...||.||||:.||::|:::::.|.| .|.:||
  Rat   911 VTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPVSLED 975

  Fly   839 WQRNTIYR-HYNRNSKQVVWFWQFVRE-TDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFC 901
            .:..|.|. .|:.:...:..||:.|.. ||.||| :||:|||...|.|:.||.||..:     ||
  Rat   976 LKSFTNYSGGYSADHPVIKIFWRVVEGFTDEEKR-KLLKFVTSCSRPPLLGFKELYPA-----FC 1034

  Fly   902 IEKVGKE-TWLPRSHTCFNRLDLPPYKSYDQ--LVEKLTFAIEETEGF 946
            |...|.: ..||.:.||.|.|.||.:  ||:  |..||.:|||...||
  Rat  1035 IHNGGSDLERLPTASTCMNLLKLPEF--YDEALLRSKLLYAIECAAGF 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736
		WW	522..554	CDD:197736
		HECTc	594..946	CDD:238033	119/371 (32%)
		HECTc	620..946	CDD:214523	112/345 (32%)
Ube3c	XP_038964472.1	IQ	47..64	CDD:197470
Ube3c	XP_038964472.1	HECTc	725..1081	CDD:238033	120/371 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910