DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Ufd4

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	1207	Identity:	232/1207 - (19%)
Similarity:	382/1207 - (31%)	Gaps:	440/1207 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PTPTSSSGAGAS-----------GSANQGYHQLSVTIEE----ASLRNNGFLKP--NPYVEL-LI 76
            |.|.::...|..           .:|||  .|:.||.||    :|.:.:..|||  .|...| ::
  Fly  1668 PVPCTNVPVGGKKTPKAQALINPDNANQ--KQIIVTSEEFPTKSSKKPSVTLKPAQQPNAVLSIV 1730

  Fly    77 DSKSKRKTDLVKNSYLPKWNEEFTV-----LITPNSTL--------HFKVLDHSSF--------R 120
            |.|.:           |..||..:|     :..||.|.        ..:|..|:..        |
  Fly  1731 DIKEQ-----------PISNENVSVPSQMSISVPNLTTTSASEVPSTSEVATHTGLLETFAAIAR 1784

  Fly   121 KDAMLG-----ERIINL-AHILQH--YNGRCEFLELTI-DLFVTSKSDNRQTKSGELVAILNGLK 176
            :....|     .:|:|. |::.:|  .|....||..:: .|...:.|.|          ..:||
  Fly  1785 RRTSQGTNIQDNQIMNAEANVNEHGDQNASGSFLGHSVTSLVKLALSSN----------FHSGL- 1838

  Fly   177 LDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSP 241
              :|..|..|.....|.    :.:.||..|:.:||:...........|.|.|:|.:|......
  Fly  1839 --LSTAQSYPSLSSNNS----ENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLE-- 1895

  Fly   242 LPNGGGDHRRSTQAPPV---------WEQQQQQSQNQQQ-------------------------- 271
                  |...|.:||.:         .::...:.:|:.:
  Fly  1896 ------DFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQVMVSRNLLTFMDDEAM 1954

  Fly   272 PLRMVNGS---------------GAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQPAAVYLP 321
            ..|:|..:               .|.:|...|.|.:          |.|.........|....||
  Fly  1955 ENRLVGVTKRKSWDDEFVLKRQFSALIPAFDPRPGR----------TNVNQTSDLEISPLGAELP 2009

  Fly   322 AGGGAAVGPPGVAGP-PIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHN 385
            .       |....|| .||||.:||
  Fly  2010 K-------PQQSGGPETIEQPLLGL---------------------------------------- 2027

  Fly   386 TRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQ--RPNSERLMHFQHWQGQRAHVVSQG 448
                            ::|..|.|.:..|:.:...|.|.  |...|.|...|..:..:...:.:.
  Fly  2028 ----------------KLRGPGIGGIPEVEIDLSNTDWTIFRAVQELLQCSQLNKLDKFRKIWEP 2076

  Fly   449 NQRYLY---SQQQQQPTAVTAQ---VTQDDEDALG--------PLPDGWEKKIQSDNRVYFV--- 496
            ....:|   |.:.|:.|.:.::   .|.|.....|        |:..|:.   .:||.:..|
  Fly  2077 TYTIVYREVSPEAQESTCLESEEFPQTPDVSSKSGASTLSPNSPMHIGFN---VADNNLCSVDDV 2138

  Fly   497 -------NHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDH---NTRRTTFED 551
                   |..|::....|.:..|  ||:::|.                .|:..   |..:...:|
  Fly  2139 LELLTQINGLNQSEIDSDVKEHG--VSVLSED----------------LFISKKITNKLQQQIQD 2185

  Fly   552 PRPGAPKGAKGVYGVPRAYER-------SFRWKLSQFRYLCQS-------NALPSHIKITVTRQT 602
            |...|..      .:|...|.       .|.::..|..:.|.|       ..|.|...:||.||.
  Fly  2186 PLVLASN------ALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQR 2244

  Fly   603 L-----FEDSY--------HQIMRLPAYE-------------LRRR--LYIIFRGEEGLDYGGVS 639
            :     ..|.:        |:.:::|..|             ..|:  |.:.|..|||... |.:
  Fly  2245 IPIMSPRRDDHEFRIGRLKHERVKVPRNEDLLMWAMQVMKTHCNRKSVLEVEFLDEEGTGL-GPT 2308

  Fly   640 REWFFLLSHEVLNPMYCLF-------------------------EYANKNNYSLQINPA-----S 674
            .|::.|::.|:.....|::                         .|.|:..:.  |.||     |
  Fly  2309 LEFYALVAAEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHG--IFPAPLPQNS 2371

  Fly   675 YVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKK---------------------- 717
            .:..:.|:||.|.|.|:|..|...|.:....:..|.:.:.:.|
  Fly  2372 EICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQKVISDRRNGDLSVVS 2436

  Fly   718 --------------------------LTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFE 756
                                      |::::::.|||..|..|..:::..:.:..:|...::..|
  Fly  2437 EDSDIVETCTKLLRTDSNKSNAFGGILSLENLKEIDPTRYQFLQEMQNLLLRKQSIEFDDTISAE 2501

  Fly   757 VLGQIIHH----------------------------------ELKENGEKERVTEENKEEYITLM 787
            ...::|:.                                  ||..||....||.:|.|.|..|:
  Fly  2502 KKHELINELKLQTQNGLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELL 2566

  Fly   788 TEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRH----- 847
            ..:.:..||.||.|.|.:|||||.||:.|..|...|..:::||.|   ...|.|..|..:
  Fly  2567 MNFILQDGIAQQMKAFSDGFNEVFPLKKLAAFTPSEARMMICGEQ---FPHWSREDIISYTEPKL 2628

  Fly   848 -YNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKV--GKET 909
             ||::|.....|...:.....::|...|||.||...:|.||.|.|    .|:...:.||  |..:
  Fly  2629 GYNKDSPGFQRFVNVLLSMSGDERKAFLQFTTGCSSLPPGGLANL----HPRLTVVRKVDAGVGS 2689

  Fly   910 WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            : |..:||.:.|.||.|.:.:.:.|:|..|.:| :||
  Fly  2690 Y-PSVNTCVHYLKLPDYPTEEIMKERLLTATKE-KGF 2724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	34/161 (21%)
		WW	364..396	CDD:197736	0/31 (0%)
		WW	397..426	CDD:278809	6/30 (20%)
		WW	478..509	CDD:197736	8/40 (20%)
		WW	522..554	CDD:197736	4/34 (12%)
		HECTc	594..946	CDD:238033	107/499 (21%)
		HECTc	620..946	CDD:214523	99/447 (22%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786
		ANK	396..509	CDD:238125
		ANK repeat	422..453	CDD:293786
		ANK repeat	455..484	CDD:293786
		F5_F8_type_C	1173..1298	CDD:329041
		MIB_HERC2	1333..1389	CDD:310955
		DamX	1576..>1725	CDD:330571	16/58 (28%)
		HECTc	2265..2725	CDD:238033	103/472 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830