DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Hecw2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001001883.1	Gene:	Hecw2 / 329152	MGIID:	2685817	Length:	1578	Species:	Mus musculus

Alignment Length:	1452	Identity:	358/1452 - (24%)
Similarity:	525/1452 - (36%)	Gaps:	549/1452 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VNGAGSAS------PTPTSSSGA-GASGSANQGYHQ---LSVTIEE---ASLRNNGFLKPNPYVE 73
            ::||..|:      ..|....|| |..|.|:...|.   :|.|:.:   ..|:...|..|:||::
Mouse   146 ISGALRATTPCITVKNPAVMMGAEGMEGGASGSLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLK 210

  Fly    74 LLIDSKSK------------RKTDLVKNSYLPKWNEE---FTVLITPNSTLHFKVLDHSSFRKD- 122
            :.|....|            |::.::.|:..|.|:.|   |..|:|  ..|..::.|  .|.|.
Mouse   211 MSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLT--DVLEIEIKD--KFAKSR 271

  Fly   123 ----AMLGERIINLAHILQH--------YN-GR-------CEFLELTIDLFVTSKSDNRQTKSGE 167
                ..||:..|.:..:|:.        || ||       ..:|:..:::..::..|......|.
Mouse   272 PIIKRFLGKLTIPVQRLLERQAGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSAHEDASPEAVGT 336

  Fly   168 LVAI--LNG---------------------------------------------LKLDMSKL--- 182
            ::.:  :||                                             |::|...|
Mouse   337 ILGVHTVNGDLGSPSDEEDMPGSHHDSTICANGPVSEDSVADGTPKHSFRTSSTLEIDTEDLIST 401

  Fly   183 --QIQPVAGQQNG-NPPVQAV------NPSVV--SDAAAGRSCMIYGGVRARMRLRS-------- 228
              :..|..|:|:. |..:.|:      .|...  |:.:.|.|..:........||.:
Mouse   402 SSRNSPPRGRQDSLNDYLDAIEHNGPARPGAASSSERSMGASPKLRSSFPTDTRLNAMLHIDSDE 466

  Fly   229 ------------SSGNSNGG-----------------------------------ETRS------ 240
                        ||....||                                   ||.|
Mouse   467 EDHEFQQDLGYPSSLEEEGGLIMCSRASRIDDGSLTSQTKPEDDNPVENEDASIHETASLEERLE 531

  Fly   241 ------------------------PLPN----------------------------GGGDHRRST 253
                                    |.|:                            .||..|.::
Mouse   532 NLPEVADGSLPSSTAPDENEANLEPQPSADQGSTELCSSQEVDQPTSGADAGASDTSGGSRRAAS 596

  Fly   254 QAPPVWEQQQQQSQ--NQQQPLRMVNGSGAAVPQTAPYPQQPPAPA------------------- 297
            :...: :|..:.||  ::.:|.........:...|.|..:..|..|
Mouse   597 ETESL-DQGSEPSQVSSETEPSDPARTESVSEASTRPEGESDPEGADSSCNESVTTQLSSVETRC 660

  Fly   298 ----LAR-PLTQVY----------GALPENTQPA--------------AVYLP-------AGGGA 326
                .|| |.|..:          .|.|.::.||              ||.:|       |...|
Mouse   661 SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTPSSLPAVQVPSREEEGSAAEAA 725

  Fly   327 AVGPPGVAGP------PIEQPGVGLPVSQSTDPQLQ-------------------------TQPA 360
            |:...|..|.      .:|......|.:.:||.|.|                         :|..
Mouse   726 ALSEQGELGEVWQRRGSLEGAAAAAPAAAATDSQPQEDGDAGDAQGACEGATAQEEGATGGSQTN 790

  Fly   361 DDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQR 425
            ..:||.:...:|.|.            |.|......|||.||.|.|..||::||||..|.|||||
Mouse   791 GHQPLRSLPSVRQDV------------SRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQR 843

  Fly   426 PNSERLMHFQHWQGQRAHVVSQG---NQRY---LYSQQQQQPTAVTAQVTQDDEDA--------- 475
            |.:.......    ||::.:.|.   |:||   ..:...::|...|:.:....|:|
Mouse   844 PTAPPAPQVL----QRSNSIQQMEQLNRRYQSIRRTMTNERPEENTSAIDGAGEEADFHQASADF 904

  Fly   476 --LGPLPDGWEKK----------------------IQSDNRVY--FVNH----------KNRTTQ 504
              ...||....:.                      :.|:...|  |.|:          :..|..
Mouse   905 RRENVLPHSTSRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHH 969

  Fly   505 WEDPRTQGQEVSLIN-----EGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR----------- 553
            :|..:.....|..:|     :..||.|||:::...|:.||||||:|.|||.|||
Mouse   970 FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSA 1034

  Fly   554 ----------------------------------------------------------------- 553

Mouse  1035 LVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPN 1099

  Fly   554 ------------------------------PG--------------------------------- 555
                                          ||
Mouse  1100 ILEILQERQPDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHP 1164

  Fly   556 ----APKGA-----KGVYGVPRA-------YERSFRWKLSQFRYLCQSNAL---PSHIKITVTRQ 601
                :|:|:     :...|..||       |:|.|..||..|....::...   |..:|:.:.|.
Mouse  1165 SYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRD 1229

  Fly   602 TLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNN 665
            .|.||:::|||.....:|:| :||:.|.|||||||.|.|||:|||:|.|:.||.|.||||:..:.
Mouse  1230 HLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDT 1294

  Fly   666 YSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEF 730
            |::||:|.|....:|.::|:|.||.:.:||.|...:.:.||.||||.:|.....:.|:|.:|.||
Mouse  1295 YTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEF 1359

  Fly   731 YNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRG 795
            :.||.|:|||:|.:. |:|.|:|:.||.|||...|||..|....|||:||:|||..|.:||:.||
Mouse  1360 HQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERG 1423

  Fly   796 IEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQVVWFW 859
            :.|||::.:.||.|||....:..||.|||||::.|..::|:.||:.||.|| .|:.|...:.|||
Mouse  1424 VVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFW 1488

  Fly   860 QFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLP 924
            ..|...:||:|.|||||||||..:|..|||.|.|||||:|||:||.||.|.|||:||||||||||
Mouse  1489 AAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLP 1553

  Fly   925 PYKSYDQLVEKLTFAIEETEGF 946
            ||.|:..|.|||..|:|||..|
Mouse  1554 PYPSFSMLYEKLLTAVEETSTF 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	33/168 (20%)
		WW	364..396	CDD:197736	6/31 (19%)
		WW	397..426	CDD:278809	18/28 (64%)
		WW	478..509	CDD:197736	8/64 (13%)
		WW	522..554	CDD:197736	19/137 (14%)
		HECTc	594..946	CDD:238033	177/353 (50%)
		HECTc	620..946	CDD:214523	168/327 (51%)
Hecw2	NP_001001883.1	HECW_N	45..164	CDD:374632	4/17 (24%)
		C2_NEDL1-like	185..320	CDD:176073	30/138 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..453		14/111 (13%)
		DMP1	<344..700	CDD:369294	44/356 (12%)
		NESP55	<463..639	CDD:115071	18/176 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..802		41/306 (13%)
		Interaction with TP73. /evidence=ECO:0000250	737..1074		72/352 (20%)
		WW	815..844	CDD:366073	18/28 (64%)
		HECW1_helix	921..987	CDD:375862	8/65 (12%)
		WW	993..1022	CDD:366073	16/28 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1075		0/44 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1193		5/25 (20%)
		HECTc	1222..1576	CDD:238033	178/355 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810