DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Hecw2

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001101688.1	Gene:	Hecw2 / 316395	RGDID:	1593244	Length:	1578	Species:	Rattus norvegicus

Alignment Length:	1457	Identity:	364/1457 - (24%)
Similarity:	528/1457 - (36%)	Gaps:	559/1457 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VNGAGSAS------PTPTSSSGA-GASGSANQGYHQ---LSVTIEE---ASLRNNGFLKPNPYVE 73
            ::||..|:      ..|....|| |..|.|:...|.   :|.|:.:   ..|:...|..|:||::
  Rat   146 ISGALRATTPCITVKNPAVMMGAEGMEGCASGSLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLK 210

  Fly    74 LLIDSKSK------------RKTDLVKNSYLPKWNEE---FTVLITPNSTLHFKVLDHSSFRKD- 122
            :.|....|            |::.::.|:..|.|:.|   |..|:|  ..|..::.|  .|.|.
  Rat   211 MSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLT--DVLEIEIKD--KFAKSR 271

  Fly   123 ----AMLGERIINLAHILQH---------YN-GR-------CEFLELTIDLFVTSKSDNRQTKSG 166
                ..||:..|.:..:|:.         || ||       ..:|:..:::..:::.|......|
  Rat   272 PIIKRFLGKLTIPVQRLLERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEAVG 336

  Fly   167 ELVAI--LNG---------------------------------------------LKLDMSKL-- 182
            .::.:  :||                                             |::|...|
  Rat   337 TILGVHTVNGDLGSPSDDEDMPGSHHDSTICANGPVSEDSVADGTPKHSFRTSSTLEIDTEDLIS 401

  Fly   183 ---QIQPVAGQQNG-NPPVQAV---NPSVVSDAAAGRSCMIYGGVRARMRLRS------------ 228
               :..|..|:|:. |..:.|:   .||....|::....|     .|..:|||
  Rat   402 TSSRNSPPRGRQDSLNDYLDAIEHNGPSRPGTASSSERPM-----GASPKLRSSFPTDTRLNAML 461

  Fly   229 ------------------SSGNSNGG-----------------------------------ETRS 240
                              ||....||                                   ||.|
  Rat   462 HIDSDEEDHDFQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQTKPEDDNPVENEDASVHETAS 526

  Fly   241 --------------PLPNGGG--DHRRSTQAPPVWEQQQQQ---SQNQQQPLRMVN--------G 278
                          .||:|..  ::..|.:..|..:|...:   ||...||....:        |
  Rat   527 LEERPENLPEVEDGSLPSGTAPDENEASVEPQPSADQGSTELCSSQEVDQPTSGTDAGASDTSVG 591

  Fly   279 SGAAVPQTAPYPQ-----------QPPAPALARPLTQVYGALPE----------------NTQPA 316
            |..|..:|....|           :|..||....:::. ...||                .||.:
  Rat   592 SRRAASETESLDQGSEPSQVSSETEPSDPARTESVSEA-STRPEGESDLEGADSSCNESVTTQLS 655

  Fly   317 AV-------------YLPA------GGGAAVGPPGVAGP----------PIEQPGVGLP------ 346
            :|             ..||      ..||....|..:||          |...|.|.:|
  Rat   656 SVETRCSSLESARFPETPAFSSQEEEDGACAAEPTSSGPTEGSQESVCTPGSLPAVQVPSREEEG 720

  Fly   347 -------------------------------VSQSTD--PQLQTQPAD----------------- 361
                                           .:.:||  ||....|.|
  Rat   721 SGAEATALSEQGELGEVWQRRGSLEGAAAAATAAATDSQPQEDGDPGDTQGACEGATAQEEGATG 785

  Fly   362 ------DEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRK 420
                  .:||.:...:|.|.            |.|......|||.||.|.|..||::||||..|.
  Rat   786 GSQTNGHQPLRSLPSVRQDV------------SRYQRVDEALPPNWEARIDSHGRIFYVDHVNRT 838

  Fly   421 TTWQRPNSERLMHFQHWQGQRAHVVSQG---NQRY---LYSQQQQQPTAVTAQVTQDDEDA---- 475
            ||||||.:.......    ||::.:.|.   |:||   ..:...::|...|:.:....|:|
  Rat   839 TTWQRPTAPPAPQVL----QRSNSIQQMEQLNRRYQSIRRTMTNERPEENTSAIDGAGEEADFHQ 899

  Fly   476 -------LGPLPDGWEKK----------------------IQSDNRVY--FVNH----------K 499
                   ...||....:.                      :.|:...|  |.|:          :
  Rat   900 ASADFRRENVLPHSTSRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVR 964

  Fly   500 NRTTQWEDPRTQGQEVSLIN-----EGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPR------ 553
            ..|..:|..:.....|..:|     :..||.|||:::...|:.||||||:|.|||.|||
  Rat   965 RDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSS 1029

  Fly   554 ----------------------------------------------------------------- 553

  Rat  1030 RPTSALVHRQHLTRQRSHSAGEVGEDSRHAGPPVLPRPASTFNTVSRPQYQDMVPVAYNDKIVAF 1094

  Fly   554 -----------------------------------PG---------------------------- 555
                                               ||
  Rat  1095 LRQPNILEILQERQPDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPH 1159

  Fly   556 ---------APKGA-----KGVYGVPRA-------YERSFRWKLSQFRYLCQSNAL---PSHIKI 596
                     :|:|:     :...|..||       |:|.|..||..|....::...   |..:|:
  Rat  1160 ALLHPSYCQSPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKL 1224

  Fly   597 TVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEY 660
            .:.|..|.||:::|||.....:|:| :||:.|.|||||||.|.|||:|||:|.|:.||.|.||||
  Rat  1225 IIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEY 1289

  Fly   661 ANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIET 725
            :..:.|::||:|.|....:|.::|:|.||.:.:||.|...:.:.||.||||.:|.....:.|:|.
  Rat  1290 SANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEY 1354

  Fly   726 IDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEW 790
            :|.||:.||.|:|||:|.:. |:|.|:|:.||.|||...|||..|....|||:||:|||..|.:|
  Rat  1355 LDEEFHQSLQWMKDNDIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKW 1418

  Fly   791 RMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQ 854
            |:.||:.|||::.:.||.|||....:..||.|||||::.|..::|:.||:.||.|| .|:.|...
  Rat  1419 RIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIV 1483

  Fly   855 VVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFN 919
            :.|||..|...:||:|.|||||||||..:|..|||.|.|||||:|||:||.||.|.|||:|||||
  Rat  1484 IRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFN 1548

  Fly   920 RLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||||||.|:..|.|||..|:|||..|
  Rat  1549 RLDLPPYPSFSMLYEKLLTAVEETSTF 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	33/169 (20%)
		WW	364..396	CDD:197736	6/31 (19%)
		WW	397..426	CDD:278809	18/28 (64%)
		WW	478..509	CDD:197736	8/64 (13%)
		WW	522..554	CDD:197736	19/137 (14%)
		HECTc	594..946	CDD:238033	177/353 (50%)
		HECTc	620..946	CDD:214523	168/327 (51%)
Hecw2	NP_001101688.1	HECW_N	45..162	CDD:406866	3/15 (20%)
		C2_NEDL1-like	185..321	CDD:176073	30/139 (22%)
		MDN1	<396..741	CDD:227596	55/350 (16%)
		NESP55	<464..632	CDD:115071	25/168 (15%)
		WW	815..844	CDD:395320	18/28 (64%)
		HECW1_helix	921..987	CDD:408233	8/65 (12%)
		WW	993..1024	CDD:197736	18/30 (60%)
		HECTc	1222..1576	CDD:238033	178/355 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810