DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Itch

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_008760557.1	Gene:	Itch / 311567	RGDID:	1359556	Length:	864	Species:	Rattus norvegicus

Alignment Length:	921	Identity:	474/921 - (51%)
Similarity:	608/921 - (66%)	Gaps:	96/921 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QLSVTIEEASLRNN--GFLKPNPYVELLIDSKSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFK 112
            ||.:|:..|.|:.|  .:..|:||||:.:|.:|| ||:...|:..|||.:..||::||.|.|.|:
  Rat    19 QLQITVISAKLKENKKNWFGPSPYVEVTVDGQSK-KTEKCNNTNSPKWKQPLTVIVTPMSKLCFR 82

  Fly   113 VLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKS-GELVAILNGLK 176
            |..|.:.:.|.:||...:::...|:..|.:.|.:.:|:.|.    .|...|:: |:|...|:||:
  Rat    83 VWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTLQLV----GDKEPTETMGDLSVCLDGLQ 143

  Fly   177 LDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNGGETRSP 241
            ::...:.          |........:..:||          |.|.:...|.|   :||.|  .|
  Rat   144 VEAEVVT----------NGETSCSEGATQNDA----------GCRPKDETRVS---TNGSE--DP 183

  Fly   242 LPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVY 306
            .....|:::|:             :.|....|    .:|...|...|.|.:||.|...|| ..|.
  Rat   184 EVAASGENKRA-------------NGNNSPSL----SNGGFKPSRPPRPSRPPPPTPRRP-ASVN 230

  Fly   307 GALPENTQPAAVYLPAGGGAAVG--PP-----------GVAGPPIEQPGVGLPVSQSTDPQ-LQT 357
            |:...|:.        ..|::.|  ||           |.|...|    :.|.:|..:.|: |.|
  Rat   231 GSPSTNSD--------SDGSSTGSLPPTNTNVNSSASEGAASGLI----IPLTISGGSGPRPLNT 283

  Fly   358 QPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTT 422
              ....|||.|||.|:||:||.|||||..:.|.|::|.|||||||.|.|..||:|||||.||.||
  Rat   284 --VSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTT 346

  Fly   423 WQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQVTQDDE-DALGPLPDGW 483
            ||||..|.:.:::.||.||:.:   :.|.|||:::..|....|      :|:.| |.|||||.||
  Rat   347 WQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIFGNQDLFAT------SQNKEFDPLGPLPPGW 405

  Fly   484 EKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTT 548
            ||:..|:.|||||||..|.|||||||:|||    :||.|||.|||:|:|..|..:|||||.|.||
  Rat   406 EKRTDSNGRVYFVNHNTRITQWEDPRSQGQ----LNEKPLPEGWEMRFTVDGIPYFVDHNRRATT 466

  Fly   549 FEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMR 613
            :.|||.|  |.|.. .|...||.|.|:.|:..||:.||..|:|.||||||||:||||||:.|||.
  Rat   467 YIDPRTG--KSALD-NGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMS 528

  Fly   614 LPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNP 678
            ....:|||||::||.||||||||||:||||||||||||||||||||||.|:||.||||||||:||
  Rat   529 FSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINP 593

  Fly   679 DHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNID 743
            |||:||:||||||||||:||:||.:||::|||||:|||.:.:||:|:|||||||||||||:|||:
  Rat   594 DHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIE 658

  Fly   744 ECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFN 808
            |||||::||||.|:||:|..|:||.||....||||||||||.::.|||::||:|:||:.|.||||
  Rat   659 ECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFN 723

  Fly   809 EVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARL 873
            |::|.::|:|||.:|||::|||||::|:.||||:.|||||.|.|||:|||||||:|.|||||.||
  Rat   724 EILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIVWFWQFVKEIDNEKRMRL 788

  Fly   874 LQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTF 938
            |||||||||:||||||:||||||||:|||||||||.||||||||||||||||||||:||.|||.|
  Rat   789 LQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLF 853

  Fly   939 AIEETEGFCQE 949
            ||||||||.||
  Rat   854 AIEETEGFGQE 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	41/125 (33%)
		WW	364..396	CDD:197736	19/31 (61%)
		WW	397..426	CDD:278809	21/28 (75%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	19/31 (61%)
		HECTc	594..946	CDD:238033	264/351 (75%)
		HECTc	620..946	CDD:214523	247/325 (76%)
Itch	XP_008760557.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988	41/125 (33%)
		WW	289..318	CDD:278809	17/28 (61%)
		WW	321..350	CDD:278809	21/28 (75%)
		WW	401..430	CDD:278809	19/28 (68%)
		WW	440..471	CDD:197736	18/30 (60%)
		HECTc	509..862	CDD:238033	265/352 (75%)
		HECTc	533..861	CDD:214523	248/327 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	971	1.000	Inparanoid score	I303
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm46091
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980