Protein Alignment Su(dx) and Smurf2

DIOPT Version :10

• Sequence 1: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Sequence 2: NP_001100531.1
• Gene: Smurf2 / 303614
• RGDID: 1310067
• Length: 748
• Species: Rattus norvegicus
• Alignment Length: 945
• Identity: 318/945 - (33%)
• Similarity: 443/945 - (46%)
• Gaps: 238/945 - (25%)

  Fly    42 GSANQGYHQLSVTIEEAS--LRNNGFLKPNPYVELLIDSKSK-RKTDLVKNSYLPKWNEEFTVLI 103
            |....|..:|.:|:..|.  ::.:.|..|:|:.::::|...: ..||.|||:..||||:.:.:.|
  Rat     5 GGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYI 69

  Fly   104 TPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTSKSDNRQTKSGEL 168
            ..:.::...|.:|....|..  |...:....:|                   |.:.||...:|.
  Rat    70 GKSDSVTISVWNHKKIHKKQ--GAGFLGCVRLL-------------------SNAINRLKDTGY- 112

  Fly   169 VAILNGLKLDMSKLQIQPVAGQQNGNPPVQAVNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNS 233
                  .:||:.||       ..|.|..|:.               .|...:::|.|:
  Rat   113 ------QRLDLCKL-------GPNDNDTVRG---------------QIVVSLQSRDRI------- 142

  Fly   234 NGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPAL 298
                                                        |:|..|
  Rat   143 --------------------------------------------GTGGQV--------------- 148

  Fly   299 ARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDE 363
                                                                    :......|.
  Rat   149 --------------------------------------------------------VDCSRLFDN 157

  Fly   364 PLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKT-----TW 423
            .||.|||.|....||..|::|.||:|.||:||  .|..|....||....:||.||..|     |.
  Rat   158 DLPDGWEERRTASGRIQYLNHITRTTQWERPT--RPASEYSSPGRPLSCFVDENTPITGTNGATC 220

  Fly   424 QRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQ 488
            .:.:..||        ....|.||.::.|:.......|.               .||:|:|::..
  Rat   221 GQSSDPRL--------AERRVRSQRHRNYMSRTHLHTPP---------------DLPEGYEQRTT 262

  Fly   489 SDNRVYFVNHKNRTTQWEDPRTQGQEVSLIN---EGPLPPGWEIRYTAAGERFFVDHNTRRTTFE 550
            ...:|||::.:...:.|.|||.. :::|.||   .||||||||||.||.|..:|||||.|.|.|.
  Rat   263 QQGQVYFLHTQTGVSTWHDPRVP-RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFT 326

  Fly   551 DPRPGA------------------------PKGAKGVYGVPRAYERSFRWKLSQFRY-LCQSNAL 590
            |||..|                        |...: ...||| |:|....||...|. |.|....
  Rat   327 DPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTE-CLTVPR-YKRDLVQKLKILRQELSQQQPQ 389

  Fly   591 PSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMY 655
            ..|.:|.|:|:.:||:||.|:|::...:|.:||.|.||||||||||||:|||.:|||||:|||.|
  Rat   390 AGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYY 454

  Fly   656 CLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTI 720
            .||:|:..:.|:|||||.|.|||:||.||.|:||.:.||::||.:|..|||:||||::|.|.:|:
  Rat   455 GLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITL 519

  Fly   721 KDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYIT 785
            .|:|.:||:.:|||:|:.:|:|... |:..|.|:....|:||.||||.||:...||||||:||:.
  Rat   520 DDMELVDPDLHNSLVWILENDITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVR 583

  Fly   786 LMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNR 850
            |...||..||||.|.....:|||||:|...||.|||:|||||:||:..:||.||:.||..:|...
  Rat   584 LYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKANTRLKHCTP 648

  Fly   851 NSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKET-WLPRS 914
            :|..|.|||:.|...|.|:||||||||||:.|||:.||..|.|:.||:.|.|.::...| .||::
  Rat   649 DSNVVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKA 713

  Fly   915 HTCFNRLDLPPYKSYDQLVEKLTFAIEETEGFCQE 949
            ||||||:|:|||:||::|.|||..|||||.||..|
  Rat   714 HTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	26/127 (20%)
		WW	364..396	CDD:197736	16/31 (52%)
		HUL4	<395..946	CDD:227354	257/584 (44%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	34/173 (20%)
		PRP40	155..>236	CDD:227435	31/90 (34%)
		WW	159..188	CDD:459800	15/28 (54%)
		WW	252..283	CDD:197736	9/30 (30%)
		WW	298..330	CDD:197736	22/31 (71%)
		HECTc	393..745	CDD:238033	188/352 (53%)