DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Wwc1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	96/457 - (21%)
Similarity:	159/457 - (34%)	Gaps:	113/457 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 PLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQE----VSLINEGPLPPGWEIRYTAAGERF 538
            |||:|||:....|.:||:::|:||||.|.|||.:..:    ...|:: .||.|||..|......:
  Rat     7 PLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISD-ELPLGWEEAYDPQVGDY 70

  Fly   539 FVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYL-----CQSNALPSHIKITV 598
            |:||||:.|..||||                    .:|:..|...|     ....||.:..:|..
  Rat    71 FIDHNTKTTQIEDPR--------------------VQWRREQEHMLKDYLVVAQEALSAQKEIYQ 115

  Fly   599 TRQ---TLFEDSYHQIMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEY 660
            .:|   .|.:..|.|:..:..::|..::.::........|                :|.....|.
  Rat   116 VKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKY----------------DPEILKAEI 164

  Fly   661 ANKNNYSLQIN--PASYVNPDHLQYFKFIGRFIAMALYHGRF--IYSGFTMPFYKRMLNKKLTIK 721
            |...:   ::|  ....|:..|...||..| |..:.....|.  ...|:.:...:.:|.:...||
  Rat   165 ATAKS---RVNKLKREMVHLQHELQFKERG-FQTLKKIDERMSDAQGGYKLDEAQAVLRETKAIK 225

  Fly   722 DI----ETIDPEFYNSLIWVKDNNIDECG--LELW-------------------FSVDFEVLGQI 761
            ..    |....:...||..:||....:.|  .:||                   .|...::.|..
  Rat   226 KAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPVPKQFLDVSSQTDISGSF 290

  Fly   762 IHHELKENGEKERVT---EENKEEYITLMTE--------WRMTRGIEQ-------QTKTFLEGFN 808
            ......:..||.|:.   ||.|.....|..:        |......|:       :.:..|:...
  Rat   291 STSSSNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMR 355

  Fly   809 EVVPLEWLKYFDERELELILCGMQDVD-----VEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNE 868
            .:.|.:|    .:.|:|.:....:.::     ..|.|...:......|||:.    |.|||.:..
  Rat   356 FISPRKW----TQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRN----QLVRELEEA 412

  Fly   869 KR 870
            .|
  Rat   413 TR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	16/30 (53%)
		WW	522..554	CDD:197736	15/31 (48%)
		HECTc	594..946	CDD:238033	56/332 (17%)
		HECTc	620..946	CDD:214523	50/303 (17%)
Wwc1	XP_002727807.1	WW	9..39	CDD:238122	15/29 (52%)
		WW	55..84	CDD:278809	13/28 (46%)
		ALDH-SF	378..>420	CDD:299846	10/41 (24%)
		C2_Kibra	661..784	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900