DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Bag3

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	305	Identity:	66/305 - (21%)
Similarity:	107/305 - (35%)	Gaps:	96/305 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 ADDEPLPAGWEIRLD-QYGRRYYVDHNTRSTYWEKPTPLPPGWE--------IRKDG-------R 408
            :|.:|||.||||::| |.|..::||||:|:|.|..|...|.|.:        ..:||       .
Mouse    19 SDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPPEGPKDTASSANGPSRDGSRLLPIRE 83

  Fly   409 GRVYYVDHNTRKTTWQRP-----------NSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPT 462
            |...|..        .||           :..|..|..|...|      .|.||:     :.:..
Mouse    84 GHPIYPQ--------LRPGYIPIPVLHEGSENRQPHLFHAYSQ------PGVQRF-----RTEAA 129

  Fly   463 AVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGW 527
            |.|.|.:|      .||..|..:..|:|.:...:.....|...:.|...|.|.|   :.|.....
Mouse   130 AATPQRSQ------SPLRGGMTEAAQTDKQCGQMPATATTAAAQPPTAHGPERS---QSPAASDC 185

  Fly   528 EIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPS 592
            ....::|.                 .|.:.:.:.|.:.:||.|                 ..:|.
Mouse   186 SSSSSSAS-----------------LPSSGRSSLGSHQLPRGY-----------------IPIPV 216

  Fly   593 HIKITVTRQTLFEDSYHQIMR--LPA----YELRRRLYIIFRGEE 631
            ..:..:||... :.|:||..:  .||    |:.::.:|...:|::
Mouse   217 IHEQNITRPAA-QPSFHQAQKTHYPAQQGEYQPQQPVYHKIQGDD 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	18/32 (56%)
		WW	397..426	CDD:278809	6/43 (14%)
		WW	478..509	CDD:197736	6/30 (20%)
		WW	522..554	CDD:197736	2/31 (6%)
		HECTc	594..946	CDD:238033	10/44 (23%)
		HECTc	620..946	CDD:214523	2/12 (17%)
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		23/61 (38%)
		WW	23..55	CDD:197736	17/31 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		18/106 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		8/32 (25%)
		BAG	426..503	CDD:214591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900