DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Wwp1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_006237992.1	Gene:	Wwp1 / 297930	RGDID:	1311734	Length:	968	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	516/989 - (52%)
Similarity:	639/989 - (64%)	Gaps:	139/989 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ASPTPTSSSGAGASGSANQGYHQLSVTIEEASL-RNNGFLKPNPYVELLIDSKSKRKTDLVKNSY 91
            |:.:|.|.:....||..     ||.||:..|.| |...:.....|.|:::|.:.| ||....:|.
  Rat    52 ATASPRSDTSDNHSGRL-----QLKVTVSSAKLKRKKNWFGTAIYTEVIVDGEIK-KTAKSSSSS 110

  Fly    92 LPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYNGRCEFLELTIDLFVTS 156
            .|||:|:..|.:.|.:||.|:|..|.:.:.||:||:..::|..:|..:|.:.|.::..:.|.:.:
  Rat   111 NPKWDEQLIVNVAPQTTLEFRVWSHHTLKADALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLEN 175

  Fly   157 KSDNRQTKSGELVAILNGLKLD----MSKLQIQPVAGQQNGN------PPVQAVNPSVVSDAAAG 211
            |:...||  |||..:|:||.::    .::....|:..||||:      .|:....|
  Rat   176 KNGIVQT--GELTVVLDGLVIEPEAVTNRSSSPPIEIQQNGDAVHENGDPLTRTTP--------- 229

  Fly   212 RSCMIYGGVRARMRLRSSSGNSNGGETRSPLPNGGGDHRRSTQAPPVWEQQQQQSQNQQQPLRMV 276
                       |:.:..:.|..|...|.:.:|:....|                         :|
  Rat   230 -----------RLAVEGTIGIDNHVSTSTVVPSSCCSH-------------------------IV 258

  Fly   277 NGSG--AAVPQTAPYPQQPPAPALARPLTQ------VYG----ALPENTQPAAVYLPAGGGAAVG 329
            ||..  ::.||.|..||..|||   :|||.      |.|    .|.::|......||:....:..
  Rat   259 NGENTPSSPPQVATRPQNTPAP---KPLTSEPTSDTVNGESSSVLADSTSAMGTSLPSEDSTSTS 320

  Fly   330 ---PPGVAGPPIEQP---------------GVGLPVSQSTDPQLQT----------QP------- 359
               ...|..||:::|               .||.......||...:          ||
  Rat   321 NCTSTTVQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSGFDKVRQPEGCVEPL 385

  Fly   360 ------ADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNT 418
                  .:.|.||:|||.|.|.:||.||||||||:|.||:|.|||||||.|.|.|||||||||||
  Rat   386 RPQSGNTNTESLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNT 450

  Fly   419 RKTTWQRPNSERLMHFQHWQGQRAHV---VSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLP 480
            |.||||||..|.:.:|:.||.||..:   :.|.|||||||          |.:...:.|..||||
  Rat   451 RTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYS----------ASMLAAENDPYGPLP 505

  Fly   481 DGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTR 545
            .||||::.|.:|||||||..:|||||||||||    |.||.|||.|||||||..|.|:|||||||
  Rat   506 PGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG----LPNEEPLPEGWEIRYTREGVRYFVDHNTR 566

  Fly   546 RTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQ 610
            .|||:|||.|.....||  |...||||||||||:.|||||||||||||:||.|:||||||||:.|
  Rat   567 TTTFKDPRNGKSSVTKG--GPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQ 629

  Fly   611 IMRLPAYELRRRLYIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASY 675
            ||.|..|:||||||:||||||||||||::||||||||||||||||||||||.||||.|||||||.
  Rat   630 IMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPAST 694

  Fly   676 VNPDHLQYFKFIGRFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDN 740
            :|||||.||.||||||||||:||:||.:||::|||||||:|||||||:|:||.||||||||::||
  Rat   695 INPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN 759

  Fly   741 NIDECGLELWFSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLE 805
            ||:|||||::||||.|:||::..|:||..|....||||||:|||.||||||.:||:::|||.||:
  Rat   760 NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLD 824

  Fly   806 GFNEVVPLEWLKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKR 870
            ||||||||:||:||||:|||::|||||:||:.||||||:||||.|||||::||||||:|||||.|
  Rat   825 GFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVR 889

  Fly   871 ARLLQFVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEK 935
            .|||||||||||:|:|||||||||||||:||||||||:|||||||||||||||||||||:||.||
  Rat   890 MRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 954

  Fly   936 LTFAIEETEGFCQE 949
            |.|||||||||.||
  Rat   955 LLFAIEETEGFGQE 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	40/125 (32%)
		WW	364..396	CDD:197736	21/31 (68%)
		WW	397..426	CDD:278809	24/28 (86%)
		WW	478..509	CDD:197736	21/30 (70%)
		WW	522..554	CDD:197736	24/31 (77%)
		HECTc	594..946	CDD:238033	274/351 (78%)
		HECTc	620..946	CDD:214523	257/325 (79%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988	40/130 (31%)
		PARM	243..>400	CDD:293666	36/184 (20%)
		WW	397..426	CDD:278809	20/28 (71%)
		WW	429..458	CDD:278809	24/28 (86%)
		WW	504..533	CDD:278809	19/28 (68%)
		WW	545..574	CDD:238122	21/28 (75%)
		HECTc	614..966	CDD:238033	275/351 (78%)
		HECTc	637..965	CDD:214523	258/327 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353672
Domainoid	1	1.000	529	1.000	Domainoid score	I279
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21385
Inparanoid	1	1.050	971	1.000	Inparanoid score	I303
OMA	1	1.010	-	-		QHG52003
OrthoDB	1	1.010	-	-		D126241at33208
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	1	1.000	-	-		otm46091
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	1	1.100	-	-	LDO	PTHR11254
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X898
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770