DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and Bag3

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001011936.1	Gene:	Bag3 / 293524	RGDID:	1307794	Length:	574	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	63/297 - (21%)
Similarity:	108/297 - (36%)	Gaps:	83/297 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 ADDEPLPAGWEIRLD-QYGRRYYVDHNTRSTYWEKPTPLPPGWE--------IRKDG-------R 408
            :|.:|||.||||::| |.|..::||||:|:|.|..|...|.|.:        ..:||       .
  Rat    19 SDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPPEGPKETASSANGPSRDGSRLLPARE 83

  Fly   409 GRVYYVDHNTRKTTWQRPNSERL-MHFQHWQGQRAHVVSQGNQRYLYSQQ--QQQPTAVTAQVTQ 470
            |...|..        .||....: :|.:..:.::.|:.      :.|||.  |:..|...|...|
  Rat    84 GHPIYPQ--------LRPGYIPIPVHHEGSENRQPHLF------HAYSQPGVQRFRTEAAAAAPQ 134

  Fly   471 DDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAG 535
            ..:   .||..|..:..|:|.:   ..........:.|...|.|.|   :.|.........::|.
  Rat   135 RSQ---SPLRGGVTETTQTDKQ---CGQVPAAATAQPPTAHGPERS---QSPAASDCSSSSSSAS 190

  Fly   536 ERFFVDHNTRRTTFEDPRPGAPKGAKGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTR 600
                             .|.:.:.:.|.:.:||.|                 ..:|...:..:||
  Rat   191 -----------------LPSSGRSSLGSHQLPRGY-----------------IPIPVIHEQNITR 221

  Fly   601 QTLFEDSYHQIMR--LPA----YELRRRLYIIFRGEE 631
            ... :.|:||..:  .||    |:.::.:|...:|::
  Rat   222 PAA-QPSFHQAQKTHYPAQQGEYQPQQPVYHKIQGDD 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	18/32 (56%)
		WW	397..426	CDD:278809	6/43 (14%)
		WW	478..509	CDD:197736	5/30 (17%)
		WW	522..554	CDD:197736	2/31 (6%)
		HECTc	594..946	CDD:238033	10/44 (23%)
		HECTc	620..946	CDD:214523	2/12 (17%)
Bag3	NP_001011936.1	WW	23..55	CDD:197736	17/31 (55%)
Bag3	NP_001011936.1	BAG	423..500	CDD:214591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900