DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(dx) and Hecw1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_017455974.1	Gene:	Hecw1 / 291209	RGDID:	1561038	Length:	1603	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	307/1028 - (29%)
Similarity:	414/1028 - (40%)	Gaps:	341/1028 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 QIQPVAGQQNGNPPVQAV------------NPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSNG 235
            :..|..|.::.:.|.|..            :||..|.:....||.      :.....||..|.|
  Rat   650 EAHPSTGSESDSSPQQGADHSCEGCDASCCSPSCYSTSCYSSSCY------SSSCYSSSCYNGN- 707

  Fly   236 GETRSPLPNGGGDHRR--STQAPPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPAL 298
                    |....|.|  |..:..:.|.....||..::.   .|.:..:||.:...|:..|
  Rat   708 --------NRFASHTRFSSVDSAKISESTVFSSQEDEEE---ENSAFESVPDSVQSPELDP---- 757

  Fly   299 ARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPG----VAGPPIEQPG------VGLPVSQ--ST 351
                ....||.|...:.||    .||.||....|    :|||...:.|      ...|:||  |.
  Rat   758 ----ESTNGAGPWQDELAA----PGGNAARTTEGLDSPMAGPSNRREGDCPMLHNSQPISQLPSL 814

  Fly   352 DPQLQTQPADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPT--PLPPGWEIRKDGRGRVYYV 414
            .|:....|..|||||..||.|:|.:||.:||||..|:|.|::|:  |.|.|. ||.   |.|
  Rat   815 RPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPSMAPTPDGM-IRS---GSV--- 872

  Fly   415 DHNTRKTTWQRPNSERLMHFQHWQGQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDD-EDALGP 478
                                        |.:.|.|:||    |..|.|..|.:..:|. ..:...
  Rat   873 ----------------------------HQMEQLNRRY----QNIQRTIATERSEEDSGNQSCEQ 905

  Fly   479 LPDGWEKKIQSDNRVYFVNHKNRTTQWE-DPRTQG-------QEVSLINEGP------------- 522
            :|||......||:..       .::|.. |.|.:|       |:|:|:.:.|
  Rat   906 IPDGGAGGGGSDSEA-------ESSQSNLDLRREGSLSPVNSQKVTLLLQSPAVKFITNPEFFTV 963

  Fly   523 -----------------------------------------------------LPPGWEIRYTAA 534
                                                                 ||.||||:....
  Rat   964 LHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQ 1028

  Fly   535 GERFFVDHNTRRTTFEDPR---------------------------------------------- 553
            |:.||||||:|.|||.|||
  Rat  1029 GKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGH 1093

  Fly   554 ----------------------------------------------------------------- 553

  Rat  1094 SLIAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLE 1158

  Fly   554 ------------------------------PG-----------APKGAKGVY----GVPRAYERS 573
                                          ||           :|:.:.|:.    ..|..|.|.
  Rat  1159 KLSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRD 1223

  Fly   574 FRWKLSQFRYLCQSNAL---PSHIKITVTRQTLFEDSYHQIMRLPAYELRR-RLYIIFRGEEGLD 634
            |..||..|....::...   |..||:.:.|..|.|.:::|:|.....||:| :|||.|.||||||
  Rat  1224 FEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLD 1288

  Fly   635 YGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRFIAMALYHGR 699
            |.|.|||:|||||.|:.||.|.||||:..:.|::||:|.|....::|::|:|.||.:.:||.|..
  Rat  1289 YSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQY 1353

  Fly   700 FIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSVDFEVLGQIIHH 764
            .:.:.||.||||.:|.....:.|:|.:|.||:.||.|:|||||.:. |:|.|:|:.||.||:...
  Rat  1354 LLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTER 1417

  Fly   765 ELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKYFDERELELILC 829
            |||..|...:|||:||:|||..|.:||:.||:.|||:..:.||.|||....:..||.|||||::.
  Rat  1418 ELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIA 1482

  Fly   830 GMQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVPVGGFAELMG 893
            |..::|:.||:.||.|| .|:.....:.|||..|...:||:|.|||||||||..||..|||.|.|
  Rat  1483 GTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRG 1547

  Fly   894 SNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEETEGF 946
            |||.:||||||.||.|.|||:||||||||||||.||..|.|||..|:|||..|
  Rat  1548 SNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETSTF 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	17/33 (52%)
		WW	397..426	CDD:278809	6/28 (21%)
		WW	478..509	CDD:197736	7/31 (23%)
		WW	522..554	CDD:197736	21/238 (9%)
		HECTc	594..946	CDD:238033	180/353 (51%)
		HECTc	620..946	CDD:214523	171/327 (52%)
Hecw1	XP_017455974.1	HECW_N	66..185	CDD:293170
		C2_NEDL1-like	206..342	CDD:176073
		WW	827..857	CDD:197736	16/29 (55%)
		WW	1017..1048	CDD:197736	19/30 (63%)
		HECTc	1247..1601	CDD:238033	181/355 (51%)
		HECTc	1271..1600	CDD:214523	173/329 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810