DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and HERC4

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	458	Identity:	119/458 - (25%)
Similarity:	217/458 - (47%)	Gaps:	35/458 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 VNHKNRTTQWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFEDPRPGAPKGA 560
            ::.:|....|...:..|.:|   |.| |....:|..|.....|..|...:.|..:         .
Human   649 IDIRNDYINWVQQQAYGMDV---NHG-LTELADIPVTICTYPFVFDAQAKTTLLQ---------T 700

  Fly   561 KGVYGVPRAYERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRLYI 625
            ..|..:..|.:::.|..:|.. :|....::...:.:.|.|:.:..|:...:.:....:.::.|.:
Human   701 DAVLQMQMAIDQAHRQNVSSL-FLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKV 764

  Fly   626 IFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGRF 690
            ||.||:.:|.|||.:|:|.|:..|:|:|.|.:|.| .:::..:..:..::.:.|   .|..||..
Human   765 IFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFEDSD---LFHLIGVI 825

  Fly   691 IAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNS---LIWVKDNNIDE--CGLELW 750
            ..:|:|:...:...|.:..||::|.||.::.|::.:.|:...|   |:...:::|:|  |   |.
Human   826 CGLAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFC---LN 887

  Fly   751 FSVDFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEW 815
            |::..|..|.....||..||....|.::|::|::....::...:.:......|..||::|...:.
Human   888 FTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKV 952

  Fly   816 LKYFDERELELILCGMQDVDVEDWQRNTIYR-HYNRNSKQVVWFWQFVRETDNEKRARLLQFVTG 879
            |..|...||:.::.|..:.|.::.::||.|: .|......:..||:...|...||:.:.|.|:||
Human   953 LLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTG 1017

  Fly   880 TCRVPVGGFAELMGSNGPQRFCIEKV-GKETWLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEET 943
            :.|:|:.|...|       :..|:.. |.|.:||.||||||.||||.|...:.|..||..||:..
Human  1018 SDRIPILGMKSL-------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHN 1075

  Fly   944 EGF 946
            |||
Human  1076 EGF 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736
		WW	397..426	CDD:278809
		WW	478..509	CDD:197736	2/12 (17%)
		WW	522..554	CDD:197736	6/31 (19%)
		HECTc	594..946	CDD:238033	100/358 (28%)
		HECTc	620..946	CDD:214523	97/332 (29%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	102/360 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810