DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(dx) and WWTR1

DIOPT Version :9

Sequence 1:	NP_001259898.1	Gene:	Su(dx) / 33379	FlyBaseID:	FBgn0003557	Length:	949	Species:	Drosophila melanogaster
Sequence 2:	NP_001161750.1	Gene:	WWTR1 / 25937	HGNCID:	24042	Length:	400	Species:	Homo sapiens

Alignment Length:	320	Identity:	72/320 - (22%)
Similarity:	104/320 - (32%)	Gaps:	107/320 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PAPALARPLTQVYGALPENTQPAAVYLPAGGGAAVGPPGVAGPPIEQPGVGLPVSQSTDPQLQTQ 358
            |.|.||.....|    ..::.||::.|..|.|||                |.|..|....:.|:.
Human    74 PGPRLAGGAQHV----RSHSSPASLQLGTGAGAA----------------GSPAQQHAHLRQQSY 118

  Fly   359 PADDEPLPAGWEIRLDQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTW 423
            ...||                               .|||||||:.....|:.|:::|..:.|||
Human   119 DVTDE-------------------------------LPLPPGWEMTFTATGQRYFLNHIEKITTW 152

  Fly   424 QRPNSERLMHFQHWQ----------GQRAHVVSQGNQRYLYSQQQQQ-PTAVTAQ--VTQDDEDA 475
            |.|.........|..          .||:..|||.|....:..|||. |:.::.|  .||:....
Human   153 QDPRKAMNQPLNHMNLHPAVSSTPVPQRSMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAG 217

  Fly   476 LGPLPDGWEKKIQSD-----NRVYFVNHKNRTTQWEDPRTQGQEVSLINEGPL------------ 523
            |..:|:....:.|..     .|:.....:.|..|.|..|   ||.:|..:.|:
Human   218 LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMR---QEAALCRQLPMEAETLAPVQAAV 279

  Fly   524 -PPGWEIRYTAAGERFFVDHNTRRTTFEDP-RPGAPKGAK----------GVYGVPRAYE 571
             ||      |...:...:.:|:     .|| ..|.|..::          |.|.||...|
Human   280 NPP------TMTPDMRSITNNS-----SDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPE 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(dx)	NP_001259898.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988
		WW	364..396	CDD:197736	0/31 (0%)
		WW	397..426	CDD:278809	13/28 (46%)
		WW	478..509	CDD:197736	6/35 (17%)
		WW	522..554	CDD:197736	7/45 (16%)
		HECTc	594..946	CDD:238033
		HECTc	620..946	CDD:214523
WWTR1	NP_001161750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..117		15/62 (24%)
		WW	125..156	CDD:197736	14/30 (47%)
		Required for interaction with PALS1. /evidence=ECO:0000269\|PubMed:21145499	222..400		24/121 (20%)
		PDZ-binding	394..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810